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Results for "

openers

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Calcium Channel (2) Endogenous Metabolite (3) Free Fatty Acid Receptor (1) GABA Receptor (1) iGluR (2) nAChR (1) Potassium Channel (29) Reactive Oxygen Species (1) Sodium Channel (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (12) Inflammation/Immunology (2) Metabolic Disease (4) Neurological Disease (13)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122114

ICA-27243 1 Publications Verification	Potassium Channel	Neurological Disease
ICA-27243 is a selective, potent and orally active KCNQ2/Q3 potassium channel opener with an EC₅₀ of 0.38 μM. ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 has antiepileptic and anticonvulsant effects .

HY-100276

Naminidil BMS 234303-01	Potassium Channel	Cardiovascular Disease
Naminidil is a cyanoguanidine K_ATP opener.

HY-N3463

Isopimaric acid	Potassium Channel	Neurological Disease
Isopimaric acid is a potent opener of large conductance calcium activated K ⁺ (BK) channels.

HY-17001A

Flupirtine 1 Publications Verification D 9998	Potassium Channel iGluR	Neurological Disease
Flupirtine(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.

HY-152847

Foslevcromakalim QLS-101	Potassium Channel	Neurological Disease
Foslevcromakalim (QLS-101) is a ATP-sensitive potassium channel opener. Foslevcromakalim is the proagent used for ocular hypotensive effect .

HY-101256

ZM226600	Potassium Channel	Others
ZM226600 is an ATP-sensitive potassium channel opener (EC₅₀: 500 nM). ZM226600 inhibits bladder spontaneous activity .

HY-117255

ZM260384	Potassium Channel	Others
ZM260384 is a K_ATP channel opener that accelerates metabolism and inhibits the decline of guinea pig isolated diaphragm function, thereby affecting muscle contraction. ZM260384 can be used to study muscle function under hypoxic conditions .

HY-108582

Y-27152	Potassium Channel	Cardiovascular Disease
Y-27152, a proagent of the K_ATP (Kir6) channel opener Y-26763, is a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state .

HY-U00173

U89232	Potassium Channel	Cardiovascular Disease
U-89232 appears to be a cardioselective K_ATP channel opener.

HY-116556

Rilmakalim HOE 234	Others	Cardiovascular Disease
Rilmakalim (HOE 234) is a potassium channel opener (PCO) that activates ATP-sensitive K ⁺ channels in the heart or other tissues .

HY-B1445

Minoxidil sulfate	Potassium Channel	Metabolic Disease
Minoxidil sulfate, a potent and ATP-sensitive K ⁺ channel opener, is the sulfated metabolite of minoxidil. Minoxidil sulfate is considered as a vasodilator to promote hair growth in vivo .

HY-101069

Y-26763 1 Publications Verification	Potassium Channel	Cardiovascular Disease
Y-26763 is a K ⁺ channel opener and active metabolite of Y-27152 . Y-26763 is an ATP-sensitive K ⁺ (K_ATP) channel activator .

HY-108593

BMS-191011 3 Publications Verification BMS-A	Potassium Channel	Neurological Disease
BMS 191011 (BMS-A) is a potent BK_Ca channel opener (large-conductance Ca ²⁺-activated potassium channel). BMS-191011 shows neuroprotective activities in rodent models of stroke .

HY-110011

Cromakalim BRL 34915	Potassium Channel	Inflammation/Immunology
Cromakalim is a potassium channel opener. Cromakalim can be used as a bronchodilator in asthma. Cromakalim inhibits the spontaneous tone of human isolated bronchi in a concentration-related manner being nearly as effective as isoprenaline or theophylline .

HY-U00201

KRN4884	Potassium Channel	Cardiovascular Disease
KRN4884 is a K ⁺ channel opener. In the presence of intracellular ATP (1 mM), KRN4884 (0.1-3 μM) activates K_ATP channels in a concentration-dependent manner (EC₅₀=0.55 μM).

HY-117283

rel-Aprikalim rel-RP 52891	Others	Others
rel-Aprikalim (rel-RP 52891) is the relative configuration of Aprikalim (HY-121183). Aprikalim (RP 52891), a potassium channel opener (KCO), activates ATP-sensitive K ⁺ (KATP) channels in guinea pig ventricular myocytes .

HY-110230

Flupirtine-d4 hydrochloride D 9998-d4 hydrochloride	Potassium Channel iGluR	Neurological Disease
Flupirtine-d4 (D 9998-d4) hydrochloride is the deuterium labeled Flupirtine. Flupirtine(D 9998) hydrochloride is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties .

HY-108069

Iptakalim hydrochloride	Potassium Channel nAChR	Neurological Disease
Iptakalim hydrochloride, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (K_ATP) opener, as well as an α₄β₂-containing nicotinic acetylcholine receptor (nAChR) antagonist .

HY-B0112

Minoxidil Maximum Cited Publications 6 Publications Verification U10858	Potassium Channel Endogenous Metabolite	Cardiovascular Disease Cancer
Minoxidil (U10858) is an ATP-sensitive potassium (K_ATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC₅₀ of 20 μM .

HY-119322

Tifenazoxide NN414	Potassium Channel	Metabolic Disease
Tifenazoxide (NN414) is a potent, orally active and SUR1/Kir6.2 selective K ^ATP channels opener. Tifenazoxide has antidiabetic effect, can inhibit glucose stimulated insulin release in vitro and in vivo, and has a beneficial effect on glucose homeostasis .

HY-135897

Urolithin C 3 Publications Verification	Calcium Channel Reactive Oxygen Species Apoptosis Endogenous Metabolite	Metabolic Disease
Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca ²⁺ channel opener and enhances Ca ²⁺ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation .

HY-B0112R

Minoxidil (Standard)	Potassium Channel Endogenous Metabolite	Cardiovascular Disease Cancer
Minoxidil (Standard) is the analytical standard of Minoxidil. This product is intended for research and analytical applications. Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM .

HY-19216

KR-30450 SKP 450	Potassium Channel	Cardiovascular Disease
KR-30450 (SKP 450) is a potent K ⁺_ATP opener, and a potassium channel activator. KR-30450 exerts more potent cardioprotective effects than Lemakalim (HY-14255). KR-30450 significantly improves reperfusion cardiac function. KR-30450 significantly attenuates reperfusion contracture and lactate dehydrogenase release .

HY-12496

NS-1619 3 Publications Verification	Potassium Channel Apoptosis	Cardiovascular Disease Cancer
NS-1619 is an opener of large conductance Ca ²⁺-activated K ⁺ (BK) channel. NS-1619 is a highly effective relaxant with an EC₅₀ of about 10?–?30?μM in several smooth muscles of blood vessels and other tissues . NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells .

HY-133596

12,14-Dichlorodehydroabietic acid	Potassium Channel GABA Receptor	Neurological Disease
12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca ²⁺-activated K ⁺ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABA_A antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca ²⁺ and stimulates transmitter release .

HY-23196S

Minoxidil-d10	Potassium Channel	Neurological Disease
Minoxidil-d₁₀ (U10858-d10) is the deuterium labeled Minoxidil. Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].

HY-W013712

GI-530159	Potassium Channel	Neurological Disease
GI-530159 is a selective opener of TREK1 and TREK2 potassium channels. GI-530159 displays selectivity for TREK1/2 over TRAAK, TASK3 and other potassium channels, with an EC₅₀ of 0.76 μM for TREK1. GI-530159 reduces rat dorsal root ganglion neuron excitability and shows potential analgesic effect .

HY-125469

ICA-105665 PF-04895162	Potassium Channel	Neurological Disease
ICA-105665 (PF-04895162) is a potent and orally active neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels opener. ICA-105665 inhibits liver mitochondrial function and bile salt export protein (BSEP) transport (IC₅₀ of 311 μM). ICA-105665 can penetrate the blood-brain barrier and has antiseizure effects .

HY-12596

JNJ-26489112	Calcium Channel Sodium Channel Potassium Channel	Neurological Disease
JNJ-26489112, a CNS-active agent, exhibits broad-spectrum anticonvulsant activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures. JNJ-26489112 inhibits voltage-gated Na ⁺ channels and N-type Ca ²⁺ channels, and is effective as a K ⁺ channel opener. JNJ-26489112 has very weak inhibition of CA-II (IC₅₀=35 μM) and CA-I (18 μM) .

HY-124424

VU0071063	Potassium Channel	Others Neurological Disease
VU0071063 is a potent and specific Kir6.2/SUR1 opener (EC₅₀=7.44 μM) and can be used for investigating Kir6.2/SUR1 expressed in the pancreas and brain. VU0071063 inhibits insulin secretion by inducing hyperpolarization of β-cell membrane potential. VU0071063 chemotype has a very steep structure-activity relationships .

HY-15589

GW9508 4 Publications Verification	Free Fatty Acid Receptor Potassium Channel	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC₅₀s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (K_ATP) channels opener. Anti-inflammatory and anti-atherosclerotic activities .

HY-121183

Aprikalim RP 52891	Potassium Channel	Cardiovascular Disease
Aprikalim (RP 52891), a potassium channel opener (KCO), activates ATP-sensitive K+ (KATP) channels in guinea pig ventricular myocytes. Using patch-clamp techniques, it was found that aprikalim enhances KATP channel activity more effectively in Mg-NDP solution compared to standard solutions. In Mg-NDP solution, aprikalim reduced the sensitivity of KATP channels to ATP, increasing the concentration of ATP required to inhibit channel activity by half (K1) from 56 μM to 180 μM. However, this effect diminished over time. Aprikalim's ability to activate KATP channels in Mg-NDP solution suggests potential therapeutic implications in modulating cardiac excitability and may relate to changes in channel protein enzymatic activity under experimental conditions .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3463

Isopimaric acid	Other Terpenoids Pinus nigra Arn. Pinaceae Terpenoids Source classification Plants	Potassium Channel
Isopimaric acid is a potent opener of large conductance calcium activated K ⁺ (BK) channels.

HY-B0112

Minoxidil 5+ Cited Publications U10858	Cardiovascular Disease Structural Classification Alkaloids Piperidine Alkaloids Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Potassium Channel Endogenous Metabolite
Minoxidil (U10858) is an ATP-sensitive potassium (K_ATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC₅₀ of 20 μM .

HY-135897

Urolithin C 3 Publications Verification	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields	Calcium Channel Reactive Oxygen Species Apoptosis Endogenous Metabolite
Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca ²⁺ channel opener and enhances Ca ²⁺ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation .

HY-B0112R

Minoxidil (Standard)	Structural Classification Alkaloids Piperidine Alkaloids Source classification Endogenous metabolite	Potassium Channel Endogenous Metabolite
Minoxidil (Standard) is the analytical standard of Minoxidil. This product is intended for research and analytical applications. Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM .

Cat. No.	Product Name	Chemical Structure

HY-23196S

Minoxidil-d10
Minoxidil-d₁₀ (U10858-d10) is the deuterium labeled Minoxidil. Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].

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openers

Inhibitors & Agonists

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Isotope-Labeled Compounds

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