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Results for "

pyridine derivative

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Derivative (2) Angiotensin Receptor (1) Beta-secretase (1) Biochemical Assay Reagents (1) CETP (1) Cholinesterase (ChE) (1) Endogenous Metabolite (11) Epigenetic Reader Domain (1) HIV (2) Isotope-Labeled Compounds (2) Keap1-Nrf2 (9) mAChR (1) NF-κB (1) PKA (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (12)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Derivative

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100438

Hydronidone	Drug Derivative	Inflammation/Immunology
Hydronidone is a pyridine derivative and an antifibrotic agent for hepatic fibrosis .

HY-B0893

3-Pyridinemethanol Nicotinyl alcohol; pyridine-3-carbinol	CETP	Metabolic Disease
3-Pyridinemethanol (Nicotinyl alcohol), a pyridine derivative, is a cholesterol-lowering agent .

HY-B1328

Pyridoxine Maximum Cited Publications 6 Publications Verification Pyridoxol	Endogenous Metabolite Keap1-Nrf2	Neurological Disease Cancer
Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-Y0030

3-Hydroxypicolinic acid 3-hydroxypyridine-2-carboxylic acid	Endogenous Metabolite	Infection
3-Hydroxypicolinic acid is a picolinic acid derivative, and belongs to the pyridine family. 3-hydroxypicolinic acid can be used to synthesize copper(II) complexes with anti-tuberculosis activity .

HY-N0682

Pyridoxine hydrochloride Maximum Cited Publications 6 Publications Verification Vitamin B6 hydrochloride	Endogenous Metabolite Keap1-Nrf2	Neurological Disease Cancer
Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-142467

HIV-1 inhibitor-11	HIV	Infection
HIV-1 inhibitor-11, a fused pyridine ring derivative, is a HIV-1 inhibitor. WO2021104413A1 ( compound 1-1b) .

HY-Y0426

2,4-Dihydroxypyridine 3-Deazauracil	HIV	Infection
2,4-Dihydroxypyridine (compound 2) is a pyridine derivative which is active against both Topo IIKHIV activity and HIV-1 replication, with a pIC50 of 5.05 and 4.07 against Topo IIKHIV and HIV-1 replication, reespectively .

HY-117966

Bibn 140	mAChR	Cardiovascular Disease
Bibn 140 is a pyridine derivative substituted with a benzene ring, which has high affinity (Ki: 12 nM) and selectivity for M2 mAChR receptors over M1 receptors .

HY-139974

BChE-IN-2	Cholinesterase (ChE)	Neurological Disease
BChE-IN-2 (compound 22) is a potent inhibitor of BChE with a Ki of 0.099 μM. BChE-IN-2 is a pyrimidine and pyridine derivative. BChE-IN-2 has the potential for the research of Alzheimer’s disease (AD) .

HY-W539799

2,6-Lutidine N-oxide 2,6-Dimethylpyridine N-oxide	Biochemical Assay Reagents	Others
2,6-Lutidine N-oxide (2,6-Dimethylpyridine N-oxide) is a plant growth regulator that can improve the initial growth of plants and increase early yield and total yield. Lutidine is the dimethyl derivative of pyridine .

HY-B1328S1

Pyridoxine-d3 Pyridoxol-d₃	NF-κB	Neurological Disease
Pyridoxine-d3 is a deuterium labeled Pyridoxine. Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway .

HY-N0682S1

Pyridoxine-d2 hydrochloride Pyridoxol-d₂ (hydrochloride); Vitamin B6-d₂ (hydrochloride)	Endogenous Metabolite Keap1-Nrf2	Neurological Disease
Pyridoxine-d₂ (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride. Pyridoxine hydrochloride is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-W267959

Diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate	Drug Derivative	Others
Diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate is a pyridine derivative that can be synthesized by the reaction of benzaldehyde, ethyl acetoacetate and NH₄HCO₃ .

HY-U00287

BACE-IN-1	Beta-secretase	Neurological Disease
BACE-IN-1 (Compound 13) is a substituted lmidazo[1 ,2-a]pyridine derivative which can inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease.

HY-167853

KR-31080 SK-1080	Angiotensin Receptor	Metabolic Disease
KR-31080 is an derivative of imidazo [4,5-b] pyridine. KR-31080 inhibits angiotensin II receptor. KR-31080 inhibits the NO production in LPS-stimulated BV-2 cells at a concentration of 2 μm with inhibition of 8.3% .

HY-N0682S

Pyridoxine-d3 hydrochloride Pyridoxol-d₃ hydrochloride; Vitamin B6-d₃ hydrochloride	Endogenous Metabolite Keap1-Nrf2	Neurological Disease
Pyridoxine-d₃ (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride. Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-B1328S

Pyridoxine-d5 Pyridoxol-d₅	Isotope-Labeled Compounds Endogenous Metabolite Keap1-Nrf2	Neurological Disease
Pyridoxine-d₅ (Pyridoxol-d₅) is a deuterium labeled Pyridoxine (HY-B1328). Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-N0682S3

Pyridoxine-13C4 hydrochloride Pyridoxol-¹³C₄ hydrochloride; Vitamin B6-¹³C₄ hydrochloride	Isotope-Labeled Compounds Endogenous Metabolite Keap1-Nrf2	Neurological Disease
Pyridoxine- ¹³C₄ (hydrochloride) is the ¹³C-labeled Pyridoxine (hydrochloride). Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-N0682R

Pyridoxine (hydrochloride) (Standard)	Endogenous Metabolite Keap1-Nrf2	Neurological Disease Cancer
Pyridoxine (hydrochloride) (Standard) is the analytical standard of Pyridoxine (hydrochloride). This product is intended for research and analytical applications. Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-N0682S2

Pyridoxine-d5 hydrochloride Pyridoxol-d₅ hydrochloride; Vitamin B6-d₅ hydrochloride	Keap1-Nrf2 Endogenous Metabolite	Neurological Disease
Pyridoxine-d₅ (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride[1]. Pyridoxine hydrochloride (Pyridoxol;Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol;Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway[2].

HY-110218

CW 008 1 Publications Verification	PKA Epigenetic Reader Domain	Others
CW 008, a derivative of pyrazole-pyridine, is a CREB or PKA pathway agonist. CW 008 also is a stem cell differentiating agent. CW 008 stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion .

HY-B1328R

Pyridoxine (Standard)	Endogenous Metabolite Keap1-Nrf2	Neurological Disease Cancer
Pyridoxine (Standard) is the analytical standard of Pyridoxine. This product is intended for research and analytical applications. Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway. In Vitro: Pyridoxine exerts a protective potential against AD, attenuates ROS levels, decreases the expressions of cytoplasmic Nrf2, and upregulates whole-cell HO-1 expression .

HY-113658

ts-SA	Endogenous Metabolite	Others
ts-SA is a carbonic anhydrase (CA) inhibitor with activity against seven human CA homologues. ts-SA can bind to the Zn(II) ion in the enzyme active site in a deprotonated form. The organic skeleton of ts-SA extends in the enzyme cavity and participates in multiple interactions with amino acid residues and water molecules. Due to its structural differences, the inhibitory performance of ts-SA is significantly better than that of another pyridine derivative. ts-SA exhibits low nanomolar inhibitory activity and is a multi-target CA inhibitor .

Cat. No.	Product Name

HY-L167

Boronic Acid Compound Library	151 compounds
Boric acid is a stable and usually non-toxic group widely used in modern synthesis to form C-C and C-heteroatom bonds. Boric acid exhibits exquisite reversible coordination characteristics and can be explored as a molecular construction tool, with specific mechanisms for controlling the structure and biological characteristics of bioconjugates. Boric acid has various activities, such as anticancer, antibacterial, and antiviral activities. In drugs, boric acid mainly exists in the form of arylboronic acid. In addition to this form, heterocycles containing boric acid, such as pyridine, pyrrole, and indole derivatives, are also very useful in pharmaceutical chemistry. Molecular modification by introducing boric acid groups into bioactive molecules has been shown to alter selectivity, physicochemical, and pharmacokinetic characteristics, and improve existing activity. MCE designs a unique collection of 151 boronic acid compounds. It is a good tool to be used for research on cancer and other diseases.

Boronic Acid Compound Library

151 compounds

Boric acid is a stable and usually non-toxic group widely used in modern synthesis to form C-C and C-heteroatom bonds. Boric acid exhibits exquisite reversible coordination characteristics and can be explored as a molecular construction tool, with specific mechanisms for controlling the structure and biological characteristics of bioconjugates. Boric acid has various activities, such as anticancer, antibacterial, and antiviral activities. In drugs, boric acid mainly exists in the form of arylboronic acid. In addition to this form, heterocycles containing boric acid, such as pyridine, pyrrole, and indole derivatives, are also very useful in pharmaceutical chemistry. Molecular modification by introducing boric acid groups into bioactive molecules has been shown to alter selectivity, physicochemical, and pharmacokinetic characteristics, and improve existing activity.

MCE designs a unique collection of 151 boronic acid compounds. It is a good tool to be used for research on cancer and other diseases.

Diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate	Biochemical Assay Reagents
Diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate is a pyridine derivative that can be synthesized by the reaction of benzaldehyde, ethyl acetoacetate and NH₄HCO₃ .

Cat. No.	Product Name	Category	Target	Chemical Structure