3-Hydroxypicolinic acid (Synonyms: 3-hydroxypyridine-2-carboxylic acid)

Name: 3-Hydroxypicolinic acid
Brand: MedChemExpress
SKU: HY-Y0030
Rating: 4.5 (1 reviews)

Cat. No.: HY-Y0030 Purity: 98.65%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

3-Hydroxypicolinic acid is a picolinic acid derivative, and belongs to the pyridine family.

For research use only. We do not sell to patients.

3-Hydroxypicolinic acid Chemical Structure

CAS No. : 874-24-8

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10 mM * 1 mL in DMSO ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

3-Hydroxypicolinic acid is a picolinic acid derivative, and belongs to the pyridine family.

IC₅₀ & Target

Human Endogenous Metabolite

Molecular Weight

139.11

Formula

C₆H₅NO₃

CAS No.

874-24-8

Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=NC=CC=C1O)O

Structure Classification

Phenols

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (359.43 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.1886 mL	35.9428 mL	71.8856 mL
5 mM	1.4377 mL	7.1886 mL	14.3771 mL
10 mM	0.7189 mL	3.5943 mL	7.1886 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (8.99 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (8.99 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.25 mg/mL (8.99 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.70%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (252 KB) HNMR (198 KB) RP-HPLC (602 KB)

Handling Instructions (2659 KB)

References

[1]. Tang K, et al. Picolinic acid as a matrix for laser mass spectrometry of nucleic acids and proteins. Rapid Commun Mass Spectrom. 1994 Sep;8(9):673-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.1886 mL	35.9428 mL	71.8856 mL	179.7139 mL
	5 mM	1.4377 mL	7.1886 mL	14.3771 mL	35.9428 mL
	10 mM	0.7189 mL	3.5943 mL	7.1886 mL	17.9714 mL
	15 mM	0.4792 mL	2.3962 mL	4.7924 mL	11.9809 mL
	20 mM	0.3594 mL	1.7971 mL	3.5943 mL	8.9857 mL
	25 mM	0.2875 mL	1.4377 mL	2.8754 mL	7.1886 mL
	30 mM	0.2396 mL	1.1981 mL	2.3962 mL	5.9905 mL
	40 mM	0.1797 mL	0.8986 mL	1.7971 mL	4.4928 mL
	50 mM	0.1438 mL	0.7189 mL	1.4377 mL	3.5943 mL
	60 mM	0.1198 mL	0.5990 mL	1.1981 mL	2.9952 mL
	80 mM	0.0899 mL	0.4493 mL	0.8986 mL	2.2464 mL
	100 mM	0.0719 mL	0.3594 mL	0.7189 mL	1.7971 mL

3-Hydroxypicolinic acid Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Hydroxypicolinic acid874-24-83-hydroxypyridine-2-carboxylic acidEndogenous MetaboliteInhibitorinhibitorinhibit

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3-Hydroxypicolinic acid (Synonyms: 3-hydroxypyridine-2-carboxylic acid)

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Complete Stock Solution Preparation Table

3-Hydroxypicolinic acid Related Classifications

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