2. Search Result
Search Result
Results for "

sphingomyelins

" in MedChemExpress (MCE) Product Catalog:

45

Inhibitors & Agonists

4

Fluorescent Dye

2

Biochemical Assay Reagents

8

Natural
Products

6

Isotope-Labeled Compounds

1

Click Chemistry

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-165136
    Sphingomyelins, milk

    SMs (buttermilk)

    		 Endogenous Metabolite Others
    Sphingomyelins, milk (SMs (buttermilk)) are compounds studied in sphingolipids, which play important roles in various biological processes.
    Sphingomyelins, milk
  • HY-D1584
    C12 NBD Sphingomyelin

    		Phospholipase Others
    C12 NBD sphingomyelin is an active derivative of sphingomyelin (HY-113498) that is tagged with fluorescent C12 nitrobenzoxadiazole (C12 NBD). C12 NBD sphingomyelin can be used as a sphingomyelinase substrate for studying the metabolism and transport of sphingomyelins (Ex=470 nm, Em=525 nm) .
    C12 NBD Sphingomyelin
  • HY-D1574
    C6 NBD Sphingomyelin

    		Fluorescent Dye Others
    C6 NBD Sphingomyelin is a fluorescent short-chain analogue of Sphingomyelin (HY-113498). Chlamydia trachomatis acquires C6 NBD Sphingomyelin endogenously synthesizes from C6-NBD-ceramide and transportes to the chlamydial inclusion. C6 NBD Sphingomyelin can incorporate into the plasma membrane .
    C6 NBD Sphingomyelin
  • HY-171160
    WYFA-15

    		SARS-CoV Infection
    WYFA-15 is a sphingomyelin synthase 1 (SMS1) inhibitor that protects mice against lethal SFTSV infection and reduce SARS-CoV-2 replication and pathogenesis. WYFA-15 can be utilized in anti-virus research .
    WYFA-15
  • HY-102041
    SMS2-IN-1
    1 Publications Verification

    		 Phospholipase Inflammation/Immunology
    SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC50 of 6.5 nM and a Kd of 37 nM. SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 (IC50 of 1000 nM) .
    SMS2-IN-1
  • HY-100353
    C12-Ceramide

    N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine

    		 Endogenous Metabolite Metabolic Disease Cancer
    C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease .
    C12-Ceramide
  • HY-P2936
    Sphingomyelin phosphodiesterase, Streptomyces sp.

    		Phospholipase Metabolic Disease
    Sphingomyelin phosphodiesterase, Streptomyces sp., a hydrolase, is involved in the sphingomyelin metabolism process. Sphingomyelin phosphodiesterase hydrolyzes the conversion of sphingomyelin to phosphocholine and ceramide. Sphingomyelin phosphodiesterase also plays an important role in cellular differentiation, various immune and inflammatory responses, and intracellular cholesterol trafficking and metabolism .
    Sphingomyelin phosphodiesterase, Streptomyces sp.
  • HY-112016A
    Sphingomyelin C20:2

    SM C20:2

    		 Endogenous Metabolite Neurological Disease
    Sphingomyelin C20:2 (SM C20:2) is a sphingomyelin biomarker metabolite. Sphingomyelin C20:2 can be used in Alzheimer's disease (AD) research .
    Sphingomyelin C20:2
  • HY-145520
    (±)-2'-hydroxy Ceramide (d18:0/18:0)

    (±)-2'-hydroxy Cer(d18:0/18:0)

    		 Endogenous Metabolite Neurological Disease
    (±)-2'-hydroxy Ceramide (d18:0/18:0) is a sphingomyelin that can be isolated from mammalian platelets stimulation by ADP .
    (±)-2'-hydroxy Ceramide (d18:0/18:0)
  • HY-N15352
    C20 Sphingomyelin (d18:1/20:1)

    		Liposome Neurological Disease Metabolic Disease
    C20 Sphingomyelin (d18:1/20:1) (SM:20:1) is a sphingomyelin. C20 Sphingomyelin (d18:1/20:1) is promising for research of motor neuron diseases such as amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) .
    C20 Sphingomyelin (d18:1/20:1)
  • HY-116258
    C16 Ceramide (d16:1,C16:0)

    		Liposome Others
    C16 Ceramide (d16:1,C16:0) is a bioactive sphingolipid that induces ordered- and gel-phase formation and thermal stabilization of palmitoylsphingomyelin-rich domains in palmitoylphosphocholine (POPC) bilayers. C16 Ceramide (d16:1,C16:0) is found in sphingomyelins in human erythrocytes .
    C16 Ceramide (d16:1,C16:0)
  • HY-131676
    C17 Sphingomyelin (d18:1/17:0)

    SM (d18:1/17:0); Heptadecanoyl Sphingomyelin; N-Heptadecanoyl-D-erythro-Sphingosylphosphorylcholine

    		 Endogenous Metabolite Metabolic Disease
    C17 Sphingomyelin is a synthetic derivative of sphingomyelin that has been used as an internal standard for the quantification of sphingomyelin.
    C17 Sphingomyelin (d18:1/17:0)
  • HY-141629S2
    N-Palmitoyl-D-sphingomyelin-d9

    Sphingomyelin 16:0-d9

    		 Isotope-Labeled Compounds Liposome Endogenous Metabolite Others
    N-Palmitoyl-D-sphingomyelin-d9 (Sphingomyelin 16:0-d9) is deuterium labeled N-Palmitoyl-D-sphingomyelin. N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles .
    N-Palmitoyl-D-sphingomyelin-d9
  • HY-Y1242
    Choline hydroxide (44% in water)

    		Biochemical Assay Reagents Others
    Choline hydroxide is a Choline hydrogen oxidized derivative and a strong organic base, can be used as the standard alkaline to adjust the pH of the medium. Choline is an orally active nutrient, serves as an important component of lecithin and sphingomyelin, promotes fat metabolism .
    Choline hydroxide (44% in water)
  • HY-141629S1
    N-Palmitoyl-D-sphingomyelin-13C

    Sphingomyelin 16:0-13C

    		 Isotope-Labeled Compounds Endogenous Metabolite Liposome Others
    N-Palmitoyl-D-sphingomyelin-13C is a deuterated labeled N-Palmitoyl-D-sphingomyelin . N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles .
    N-Palmitoyl-D-sphingomyelin-13C
  • HY-141629
    N-Palmitoyl-D-sphingomyelin

    Sphingomyelin 16:0

    		 Liposome Endogenous Metabolite Cancer
    N-palmitoyl-D-sphingomyelin (sphingomyelin 16:0) is a component of LDL-carrying liposomes. N-palmitoyl-D-sphingomyelin can be used in colorectal cancer research .
    N-Palmitoyl-D-sphingomyelin
  • HY-141629S
    N-Palmitoyl-D-sphingomyelin-d31

    		Isotope-Labeled Compounds Endogenous Metabolite Others
    N-Palmitoyl-D-sphingomyelin-d31 is deuterium labeled N-Palmitoyl-D-sphingomyelin.
    N-Palmitoyl-D-sphingomyelin-d31
  • HY-167820
    3-Ketosphingosine

    		Biochemical Assay Reagents
    3-Ketosphingosine trifluoroacetate is a chemically modified sphingomyelin analog with specific enzymatic pathway research activity. It is mainly used to explore the functions of sphingomyelin kinases and lyases in sphingomyelin metabolism. 3-Ketosphingosine trifluoroacetate has important application value in the study of cell signal transduction and related diseases. The study of 3-Ketosphingosine trifluoroacetate helps to deepen the understanding of sphingomyelin-related biological processes.
    3-Ketosphingosine
  • HY-129084
    Propargylcholine bromide

    		Biochemical Assay Reagents Others
    Propargylcholine bromide is a choline analogue containing terminal propargyl that can be incorporated into all classes of Choline-containing phospholipids such as phosphatidylcholine and sphingomyelin, labeling Choline-containing phospholipids. Propargylcholine bromide-labeled phospholipid molecules can be visualized in cells with high sensitivity and spatial resolution. Propargylcholine bromide can be used as a molecular tool to study the biochemical and metabolic processes of Choline-containing phospholipids in cells . Propargylcholine (bromide) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargylcholine bromide
  • HY-165062
    C18 Sphingomyelin (d18:1/18:0)

    Stearoyl sphingomyelin; Sphingomyelin (d18:1/18:0); N-Octadecanoyl sphingosylphosphorylcholine

    		 Others Metabolic Disease
    C18 Sphingomyelin (d18:1/18:0) is a form of sphingomyelin and can be used for study of sphingolipid metabolites .
    C18 Sphingomyelin (d18:1/18:0)
  • HY-165075S
    C26 Sphingomyelin (d18:1/26:0)-d4

    		Isotope-Labeled Compounds Biochemical Assay Reagents Others
    C26 Sphingomyelin (d18:1/26:0)-d4 is deuterium labeled C26 Sphingomyelin (d18:1/26:0). C26 Sphingomyelin (d18:1/26:0) is a biochemical reagent.
    C26 Sphingomyelin (d18:1/26:0)-d4
  • HY-113498
    Sphingomyelin
    1 Publications Verification

    		 Endogenous Metabolite Neurological Disease Metabolic Disease Inflammation/Immunology
    Sphingomyelin is a eukaryotic sphingolipid and one of the major constituents of cell membranes and particularly abundant in the myelin sheath that surrounds neuronal axons. Sphingomyelin plays an important role in cell processes, the regulation of inflammatory responses, and signal transduction. Sphingomyelin metabolism is associated with various central nervous system diseases and Niemann–Pick disease .
    Sphingomyelin
  • HY-W923642
    Sphingomyelin (d18:1/12:0)

    		Endogenous Metabolite
    Sphingomyelin (d18:1/12:0) is a polar lipid with the activity of regulating cell signaling. Sphingomyelin (d18:1/12:0) plays an important role in cell membranes, affecting membrane fluidity and stability. Sphingomyelin (d18:1/12:0) is also involved in lipid metabolism and has the potential to promote neuronal cell growth. Sphingomyelin (d18:1/12:0) plays a key role in the function and development of the nervous system.
    Sphingomyelin (d18:1/12:0)
  • HY-N8518
    Malabaricone C
    1 Publications Verification

    		 Phospholipase p38 MAPK Apoptosis NF-κB Metabolic Disease Inflammation/Immunology Cancer
    Malabaricone C is an orally active and noncompetitive sphingomyelin synthase (SMS) inhibitor with IC50 values of 3 μM and 1.5 μM for SMS 1 and SMS 2, respectively. Malabaricone C reduces body weight gain, improves glucose tolerance, and decreases lipid accumulation in the liver, showing significant prevention of high fat diet-induced fatty liver in mice. Malabaricone C has anti-inflammatory effects, which is found in the fruits of Myristica cinnamomea King. Malabaricone C is promising for research of obesity and immunological disorders caused due to hyper-activation of T-cells .
    Malabaricone C
  • HY-166226
    C2 Sphingomyelin (d18:1/2:0)

    		Biochemical Assay Reagents Metabolic Disease
    C2 Sphingomyelin (d18:1/2:0) is an ester product.
    C2 Sphingomyelin (d18:1/2:0)
  • HY-165075
    C26 Sphingomyelin (d18:1/26:0)

    		Biochemical Assay Reagents Others
    C26 Sphingomyelin (d18:1/26:0) is a biochemical reagent.
    C26 Sphingomyelin (d18:1/26:0)
  • HY-114307
    Ly93
    3 Publications Verification

    		 Phospholipase Inflammation/Immunology
    Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC50 of 91 nM .
    Ly93
  • HY-145549
    C20 Sphingomyelin (d18:1/20:0)

    N-eicosanoyl-D-erythro-Sphingosylphosphorylcholine; SM(d18:1/20:0)

    		 Endogenous Metabolite Endocrinology
    C20 Sphingomyelin (d18:1/20:0) (N-eicosanoyl-D-erythro-Sphingosylphosphorylcholine; SM(d18:1/20:0)) is a naturally occurring sphingolipid. C20 Sphingomyelin (d18:1/20:0) levels are upregulated in the hippocampus of streptozotocin (HY-13753)-induced diabetic rats and in human plasma, positively correlating with insulin resistance in obese humans. C20 Sphingomyelin (d18:1/20:0) is also upregulated in the liver of a mouse model of Niemann-Pick C1 disease, a neurodegenerative cholesterol sphingolipid lysosomal storage disorder.
    C20 Sphingomyelin (d18:1/20:0)
  • HY-164267
    Sphingomyelin (d18:1,C14:0)

    SM (d18:1/14:0)

    		 Endogenous Metabolite Others
    Sphingomyelin (d18:1,C14:0), a major sphingolipid in mammalian cells, increases membrane molecular order .
    Sphingomyelin (d18:1,C14:0)
  • HY-148388
    N-Stearoylsphingomyelin

    N-Stearoyl-D-sphingomyelin

    		 Phospholipase Cancer
    N-Stearoylsphingomyelin (N-Stearoyl-D-sphingomyelin) is a sphingolipid, which can inhibit Phospholipase Cδ1 (PLCδ1) .
    N-Stearoylsphingomyelin
  • HY-150559
    SMS2-IN-3

    		Phospholipase Infection Others Cancer
    SMS2-IN-3 is a potent and selective SMS2inhibitor (IC50=2.2 nM), significantly reduces the hepatic SM (22:0) levels .
    SMS2-IN-3
  • HY-112713
    SMS2-IN-2

    		Phospholipase Inflammation/Immunology
    SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC50s of 100 nM and 56 μM for SMS2 and SMS1, respectively. Anti-chronic inflammatory activity .
    SMS2-IN-2
  • HY-135642
    SMS1-IN-1

    		Phospholipase Inflammation/Immunology
    SMS1-IN-1, compound SAPA 1j, is a novel and the most potent sphingomyelin synthase 1 (SMS1) inhibitor with an IC50 value of 2.1 μM. SMS1-IN-1 has the potential for the treatment of atherosclerosis .
    SMS1-IN-1
  • HY-D1749
    C6 NBD L-threo-ceramide

    		Fluorescent Dye Others
    C6 NBD L-threo-ceramide is a cell-permeable analog of ceramides that is tagged with a fluorescent group C6 nitrobenzoxadiazole (C6 NBD). It is rapidly transferred between liposomes, labels the Golgi apparatus, and is metabolized to C6 NBD sphingomyelin in BHK cells and V79 fibroblasts.
    C6 NBD L-threo-ceramide
  • HY-165069
    N-Docosanoyl-D-erythro-sphingosylphosphorylcholine

    Sphingomyelin (d18:1 C22:0)

    		 Others Others
    N-Docosanoyl-D-erythro-sphingosylphosphorylcholine (Sphingomyelin (d18:1 C22:0)) is a compound that appears in the plasma sphingolipid profile after chronic hepatitis C virus infection. The level of this substance in plasma is associated with hepatic steatosis and may be an independent factor of hepatic steatosis.
    N-Docosanoyl-D-erythro-sphingosylphosphorylcholine
  • HY-155111
    nSMase2-IN-1

    		Phospholipase Neurological Disease
    nSMase2-IN-1 is an orally active Neutral sphingomyelinase 2 (nSMase2) inhibitor with an IC50 value of 0.13 ± 0.06 μM. nSMase2-IN-1 is metabolically stable in liver microsomes and orally available with a favorable brain-to-plasma ratio. nSMase2-IN-1 can be used for nervous system disease research .
    nSMase2-IN-1
  • HY-W778830
    Bodipy C12-ceramide

    		Drug Metabolite Neurological Disease
    Bodipy C12-ceramide (B12Cer) is a fluorescently tagged form of C12-Ceramide (HY-100353) that displays excitation/emission maxima of 505/540 nm, respectively. Bodipy C12-ceramide is formed when acid sphingomyelinase hydrolyzes BODIPY-C12 sphingomyelin in vitro and has been used to quantify acid sphingomyelinase activity in plasma with Niemann-Pick disease .
    Bodipy C12-ceramide
  • HY-116535A
    DL-threo-PPMP hydrochloride

    		Parasite Infection
    DL-threo-PPMP hydrochloride is an inhibitor of sphingosine synthetase in Plasmodium falciparum. DL-threo-PPMP hydrochloride inhibits the activity of sphingosine synthetase (sphingosine synthetase) by binding to a substrate that mimics sphingosine. This inhibition leads to a rapid decline in sensitive sphingomyelin synthase (SSS) activity, selectively disrupting the interconnected tubular network of TVM in the cytoplasm of the host cell, and this inhibition also blocks the proliferation of the parasite. DL-threo-PPMP hydrochloride can be used in the study of malaria parasite biology and the search for new antimalarial strategies .
    DL-threo-PPMP hydrochloride
  • HY-W356116
    C6 NBD Ceramide

    Nbd-ceramide

    		 Fluorescent Dye Others
    C6 NBD Ceramide is a Golgi apparatus fluorescent probe with cell membrane permeability. C6 NBD Ceramide can be used for fast and convenient green fluorescent labeling of Golgi in living and fixed cells, and can be used to observe changes in Golgi morphology in living cells (Ex=466 nm, Em=536 nm). C6-NBD-ceramide is metabolized to fluorescent sphingomyelin and glucosylceramide, can be used for the study of sphingolipid transport and metabolic mechanism .
    C6 NBD Ceramide
  • HY-117057
    Hexaenoic acid

    		Endogenous Metabolite Metabolic Disease
    Very long chain polyunsaturated fatty acids (VLCPUFAs) are important components of ceramides and sphingomyelin and are present in retina, sperm, and brain. Tetratriaconta-16(Z),19(Z),22(Z),25(Z),28(Z),31(Z)-hexaenoic acid is a C34:6 VLCPUFA whose specific biological actions are largely unknown. This VLCPUFA, along with others, has been investigated for its role in activating protein kinase C.
    Hexaenoic acid
  • HY-N6798
    Myriocin
    5+ Cited Publications

    Thermozymocidin; ISP-I

    		 HCV Antibiotic Infection
    Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL for inhibiting HCV infection .
    Myriocin
  • HY-N6798R
    Myriocin (Standard)

    Thermozymocidin (Standard); ISP-I (Standard)

    		 HCV Antibiotic Infection
    Myriocin (Standard) is the analytical standard of Myriocin. This product is intended for research and analytical applications. Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL for inhibiting HCV infection[1][2][3].
    Myriocin (Standard)
  • HY-108496
    Sphingosine-1-phosphate
    Maximum Cited Publications
    9 Publications Verification

    S1P

    		 Endogenous Metabolite LPL Receptor Inflammation/Immunology Endocrinology Cancer
    Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca 2+ as an extracellular ligand for G protein-coupled receptors . Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids . Sphingosine-1-phosphate stimulates the DNA synthesis, cell proliferation and migration .
    Sphingosine-1-phosphate
  • HY-108496S
    Sphingosine-1-phosphate-d7

    S1P-d7

    		 Endogenous Metabolite LPL Receptor Endocrinology
    Sphingosine-1-phosphate-d7 is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2].
    Sphingosine-1-phosphate-d7
  • HY-117057S
    Hexaenoic acid-d6

    		Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    Hexaenoic acid-d6 is deuterium labeled Hexaenoic acid. Very long chain polyunsaturated fatty acids (VLCPUFAs) are important components of ceramides and sphingomyelin and are present in retina, sperm, and brain. Tetratriaconta-16(Z),19(Z),22(Z),25(Z),28(Z),31(Z)-hexaenoic acid is a C34:6 VLCPUFA whose specific biological actions are largely unknown. This VLCPUFA, along with others, has been investigated for its role in activating protein kinase C .
    Hexaenoic acid-d6

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: