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steroidal estrogen

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60

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9

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19

Isotope-Labeled Compounds

2

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0487
    Ethisterone

    Pregneninolone; 17α-Ethynyltestosterone

    		 Estrogen Receptor/ERR Endocrinology
    Ethisterone (Pregneninolone), a synthetic steroidal estrogen, is an orally active steroidal contraceptive agent. Ethisterone is reported for androgenic activity, used for the research of the gynecological disorders .
    Ethisterone
  • HY-113293B
    Estrone sulfate sodium
    1 Publications Verification

    		 Estrogen Receptor/ERR Endogenous Metabolite Cancer
    Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). Estrone sulfate can be used for the research of breast cancer .
    Estrone sulfate sodium
  • HY-105184
    YM511

    		Cytochrome P450 Endocrinology
    YM511 is a highly specific non-steroidal aromatase inhibitor. YM511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM511 slightly inhibits production of other steroid hormones. YM511 has the potential for suppressing estrogen-dependent action research without affecting serum levels of other steroid hormones .
    YM511
  • HY-B0216
    Ethinylestradiol
    2 Publications Verification

    Ethynyl estradiol; 17α-Ethynylestradiol

    		 Estrogen Receptor/ERR Endogenous Metabolite Endocrinology Cancer
    Ethinylestradiol is an orally active steroidal estrogen. Ethinylestradiol is widely used in research on menopausal symptoms, gynecological conditions, and certain hormone-sensitive cancers .
    Ethinylestradiol
  • HY-B1403
    Dienestrol

    		Estrogen Receptor/ERR Endocrinology Cancer
    Dienestrol is a synthetic, non-steroidal estrogen, is an estrogen receptor agonist, for the treatment of menopausal and postmenopausal symptoms.
    Dienestrol
  • HY-113293A
    Estrone sulfate potassium
    1 Publications Verification

    		 Endogenous Metabolite Endocrinology Cancer
    Estrone sulfate potassium is a natural endogenous steroid and is an estrogen ester and conjugate .
    Estrone sulfate potassium
  • HY-151199
    Steroid sulfatase/17β-HSD1-IN-1

    		Steroid Sulfatase Endocrinology Cancer
    Steroid sulfatase/17β-HSD1-IN-1 is a potent steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitor with an IC50 value of 28 nM for cellular human steroid sulfatase. Steroid sulfatase/17β-HSD1-IN-1 can be used to research estrogen-dependent diseases .
    Steroid sulfatase/17β-HSD1-IN-1
  • HY-117649
    RU-39411

    		Others Cancer
    RU-39411 is a steroidal anti-estrogen with mixed estrogenic/antiestrogen activity. RU-39411 has shown inhibitory effects on cell growth in the MCF-7 breast cancer model, with the effect being correlated with its binding affinity to the estrogen receptor. RU-39411 was able to downregulate the estrogen binding capacity of cells, but did not reduce estrogen receptor mRNA levels, indicating that the grafting of its side chain prevents the antagonistic effects usually associated with steroidal estrogens. The administration of RU-39411 can promote the synthesis of progesterone receptors, further supporting its activity as an estrogen .
    RU-39411
  • HY-W040046
    Nafoxidine hydrochloride

    Nafoxidene hydrochloride

    		 Estrogen Receptor/ERR Cancer
    Nafoxidine hydrochloride is a non-steroidal estrogen receptor antagonist with antitumor activity for breast cancer .
    Nafoxidine hydrochloride
  • HY-150542
    Steroid sulfatase-IN-2

    		Steroid Sulfatase Cancer
    Steroid sulfatase -IN-2 is an active steroid sulfatase (STS) inhibitor with an IC50 value of 109.5 nM. Steroid sulfatase-IN-2 can be used for the research of hormone-dependent cancers, such as estrogen-dependent breast and endometrial cancer .
    Steroid sulfatase-IN-2
  • HY-128793
    trans-Stilbene

    (E)-Stilbene

    		 Fluorescent Dye Others
    trans-Stilbene ((E)-Stilbene) is used in the manufacturing of dye lasers, optical brighteners, non-steroidal synthetic estrogens.
    trans-Stilbene
  • HY-118242
    RU 45144

    		Others Others
    RU 45144 is an anti-estrogen compound that has the activity of antagonizing the binding of estrogen receptors to calmodulin. RU 45144 can inhibit the binding of estrogen receptors to calmodulin, and its effect is similar to that of tamoxifen. Its anti-estrogen effect may be related to specific side chains in the molecular structure, and the steroid skeleton may be involved in its anti-proliferative activity.
    RU 45144
  • HY-128793S1
    trans-Stilbene-d12

    (E)-Stilbene-d12

    		 Isotope-Labeled Compounds Others
    trans-Stilbene-d12 is the deuterium labeled trans-Stilbene[1]. trans-Stilbene ((E)-Stilbene) is used in the manufacturing of dye lasers, optical brighteners, non-steroidal synthetic estrogens[2].
    trans-Stilbene-d12
  • HY-128793S2
    trans-Stilbene-d10

    (E)-Stilbene-d10

    		 Isotope-Labeled Compounds Others
    trans-Stilbene-d10 is the deuterium labeled trans-Stilbene[1]. trans-Stilbene ((E)-Stilbene) is used in the manufacturing of dye lasers, optical brighteners, non-steroidal synthetic estrogens[2].
    trans-Stilbene-d10
  • HY-128793S3
    trans-Stilbene-d2

    (E)-Stilbene-d2

    		 Isotope-Labeled Compounds Others
    trans-Stilbene-d2 is the deuterium labeled trans-Stilbene[1]. trans-Stilbene ((E)-Stilbene) is used in the manufacturing of dye lasers, optical brighteners, non-steroidal synthetic estrogens[2].
    trans-Stilbene-d2
  • HY-128793S
    trans-Stilbene-13C2

    		Isotope-Labeled Compounds Others
    trans-Stilbene- 13C2 is the 13C labeled trans-Stilbene[1]. trans-Stilbene ((E)-Stilbene) is used in the manufacturing of dye lasers, optical brighteners, non-steroidal synthetic estrogens[2].
    trans-Stilbene-13C2
  • HY-111484
    GDC-0927
    3 Publications Verification

    SRN-927

    		 Estrogen Receptor/ERR Cancer
    GDC-0927 (SRN-927) is a potent, non-steroidal, orally bioavailable, selective estrogen receptor antagonist .
    GDC-0927
  • HY-123420
    Dinordrin

    Dinordrin I

    		 Steroid Sulfatase Metabolic Disease
    Dinordrin (Dinordrin I) is a steroid with a luteolytic effect. Dinordrin can cause depression of both plasma estrogen and progesterone levels .
    Dinordrin
  • HY-113293BS
    Estrone sulfate-d5 sodium

    		Estrogen Receptor/ERR Endogenous Metabolite Cancer
    Estrone sulfate-d5 (sodium) is the deuterium labeled Estrone sulfate sodium. Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].
    Estrone sulfate-d5 sodium
  • HY-113293BS1
    Estrone sulfate-d4 sodium

    		Estrogen Receptor/ERR Endogenous Metabolite Cancer
    Estrone sulfate-d4 (sodium) is deuterium labeled Estrone sulfate (sodium). Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].
    Estrone sulfate-d4 sodium
  • HY-B2158
    Chlorotrianisene

    		Estrogen Receptor/ERR COX Cardiovascular Disease Endocrinology
    Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood .
    Chlorotrianisene
  • HY-150543
    Steroid sulfatase-IN-3

    		Steroid Sulfatase Cancer
    Steroid sulfatase-IN-3 (compound 1q) is a potent STS (Steroid sulfatase) inhibitor, with an IC50 of 25.8 nM. Steroid sulfatase-IN-3 shows antiproliferative activity against T-47D estrogen-dependent breast cancer cells, with an IC50 of 1.04 µM .
    Steroid sulfatase-IN-3
  • HY-B0672
    Estradiol valerate

    β-Estradiol 17-valerate

    		 Estrogen Receptor/ERR Endocrinology Cancer
    Estradiol valerate (β-Estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.
    Estradiol valerate
  • HY-B0891
    17α-Hydroxyprogesterone
    2 Publications Verification

    17-Hydroxyprogesterone; 17-OHP

    		 Progesterone Receptor Endogenous Metabolite Others
    17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progesterone that serves as a chemical intermediate in the biosynthesis of other steroid hormones, including glucocorticoids, androgens, and estrogens.
    17α-Hydroxyprogesterone
  • HY-N6741
    β-Zearalenol

    		Others Infection Endocrinology
    β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level .
    β-Zearalenol
  • HY-B2158S
    Chlorotrianisene-d9

    		Estrogen Receptor/ERR COX Cardiovascular Disease Endocrinology
    Chlorotrianisene-d9 is the deuterium labeled Chlorotrianisene. Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood[1][2][3].
    Chlorotrianisene-d9
  • HY-12452
    DPN
    10+ Cited Publications

    Diarylpropionitrile

    		 Estrogen Receptor/ERR Apoptosis Autophagy Neurological Disease
    DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases .
    DPN
  • HY-B2158R
    Chlorotrianisene (Standard)

    		Estrogen Receptor/ERR COX Cardiovascular Disease Endocrinology
    Chlorotrianisene (Standard) is the analytical standard of Chlorotrianisene. This product is intended for research and analytical applications. Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood .
    Chlorotrianisene (Standard)
  • HY-137449
    Rintodestrant

    G1T48

    		 Estrogen Receptor/ERR CDK Cancer
    Rintodestrant (G1T48) is an orally active, non-steroidal and selective estrogen receptor degrader. Rintodestrant (G1T48) is also a CDK4/6 inhibitor .
    Rintodestrant
  • HY-118861
    Enclomiphene

    (E)-Clomiphene; trans-Clomiphene; Enclomifene

    		 Estrogen Receptor/ERR Metabolic Disease Endocrinology
    Enclomiphene ((E)-Clomiphene) is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes .
    Enclomiphene
  • HY-118861B
    Enclomiphene hydrochloride

    (E)-Clomiphene hydrochloride; trans-Clomiphene hydrochloride; Enclomifene hydrochloride

    		 Estrogen Receptor/ERR Metabolic Disease Endocrinology
    Enclomiphene ((E)-Clomiphene) hydrochloride is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene hydrochloride can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes .
    Enclomiphene hydrochloride
  • HY-14248
    Letrozole
    15+ Cited Publications

    CGS 20267

    		 Cytochrome P450 Autophagy Cancer
    Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer .
    Letrozole
  • HY-129433
    17β-HSD1-IN-2

    		Others Endocrinology
    17β-HSD1-IN-2 (PBRM) is a non-estrogenic and steroidal covalent irreversible inhibitor of 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) (Ki=368 nM). 17β-HSD1-IN-2 can be used for the research of estrogen-dependent disorders .
    17β-HSD1-IN-2
  • HY-151201
    Steroid sulfatase/17β-HSD1-IN-3

    		Steroid Sulfatase Cancer
    Steroid sulfatase/17β-HSD1-IN-3 (compound 19) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-3 irreversibly inhibits hSTS activity with anIC50 value of 27 nM. Steroid sulfatase/17β-HSD1-IN-3 can be used in the study of endometriosis and other estrogen-dependent diseases .
    Steroid sulfatase/17β-HSD1-IN-3
  • HY-151202
    Steroid sulfatase/17β-HSD1-IN-4

    		Steroid Sulfatase Cancer
    Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-4 irreversibly inhibits hSTS activity with anIC50 value of 63 nM. Steroid sulfatase/17β-HSD1-IN-4 can be used in the study of endometriosis and other estrogen-dependent diseases .
    Steroid sulfatase/17β-HSD1-IN-4
  • HY-B0672S
    Estradiol valerianate-d9

    		Isotope-Labeled Compounds Estrogen Receptor/ERR Endocrinology Cancer
    Estradiol valerianate-d9 is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.
    Estradiol valerianate-d9
  • HY-118861A
    Enclomiphene citrate
    5 Publications Verification

    (E)-Clomiphene citrate; trans-Clomiphene citrate; Enclomifene citrate

    		 Estrogen Receptor/ERR Metabolic Disease Endocrinology
    Enclomiphene ((E)-Clomiphene) citrate is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene citrate can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes .
    Enclomiphene citrate
  • HY-B0672S1
    Estradiol valerianate-d4

    β-Estradiol 17-valerate-d4

    		 Isotope-Labeled Compounds Estrogen Receptor/ERR Endocrinology Cancer
    Estradiol valerianate-d4 is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.
    Estradiol valerianate-d4
  • HY-148225
    Fulvestrant 3-β-D-Glucuronide

    		Others Cancer
    Fulvestrant 3-β-D-Glucuronide, a metabolite, is glucuronide and sulfate conjugates of Fulvestrant (HY-13636), a pure anti-estrogenic steroid. Fulvestrant 3-β-D-Glucuronide can be used for the research of breast cancer .
    Fulvestrant 3-β-D-Glucuronide
  • HY-B0141S
    Estradiol-d3

    β-Estradiol-d3; 17β-Estradiol-d3; 17β-Oestradiol-d3

    		 Estrogen Receptor/ERR Endogenous Metabolite Endocrinology Cancer
    Estradiol-d3 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
    Estradiol-d3
  • HY-B0672R
    Estradiol valerate (Standard)

    β-Estradiol 17-valerate (Standard)

    		 Estrogen Receptor/ERR Endocrinology Cancer
    Estradiol valerianate (Standard) is the analytical standard of Estradiol valerianate. This product is intended for research and analytical applications. Estradiol valerate (β-Estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.
    Estradiol valerate (Standard)
  • HY-B0891S
    17α-Hydroxyprogesterone-d8

    17-Hydroxyprogesterone-d8; 17-OHP-d8

    		 Isotope-Labeled Compounds Progesterone Receptor Endogenous Metabolite Others
    17α-Hydroxyprogesterone-d8 is the deuterium labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
    17α-Hydroxyprogesterone-d8
  • HY-109176
    Giredestrant
    5 Publications Verification

    GDC-9545; RG6171

    		 Estrogen Receptor/ERR Cancer
    Giredestrant (GDC-9545), a non-steroidal estrogen receptor (ER) ligand, is an orally active and selective ER antagonist. Giredestrant potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity .
    Giredestrant
  • HY-B0891S1
    17α-Hydroxyprogesterone-13C3

    17-Hydroxyprogesterone-13C3; 17-OHP-13C3

    		 Progesterone Receptor Endogenous Metabolite Others
    17α-Hydroxyprogesterone- 13C3 is the 13C-labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
    17α-Hydroxyprogesterone-13C3
  • HY-B0141S1
    Estradiol-d4
    1 Publications Verification

    β-Estradiol-d4; 17β-Estradiol-d4; 17β-Oestradiol-d4

    		 Estrogen Receptor/ERR Endogenous Metabolite Endocrinology Cancer
    Estradiol-d4 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].
    Estradiol-d4
  • HY-B0141S3
    Estradiol-d2

    β-Estradiol-d2; 17β-Estradiol-d2; 17β-Oestradiol-d2

    		 Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite Endocrinology Cancer
    Estradiol-d2 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].
    Estradiol-d2
  • HY-135903
    Giredestrant tartrate

    GDC-9545 tartrate; RG6171 tartrate

    		 Estrogen Receptor/ERR Cancer
    Giredestrant tartrate (GDC-9545 tartrate), a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist. Giredestrant tartrate potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Anti-tumor activity .
    Giredestrant tartrate
  • HY-B0141S2
    Estradiol-d5

    β-Estradiol-d5; 17β-Estradiol-d5; 17β-Oestradiol-d5

    		 Estrogen Receptor/ERR Endogenous Metabolite Endocrinology Cancer
    Estradiol-d5 is deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].
    Estradiol-d5
  • HY-110157
    AC-186

    		Estrogen Receptor/ERR Neurological Disease
    AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist with EC50s of 6 nM and 5000 nM for ERβ and ERα, respectively. AC-186 shows gender selective neuroprotective effects in a male rat model of Parkinson's disease .
    AC-186
  • HY-N6741R
    β-Zearalenol (Standard)

    		Others Infection Endocrinology
    β-Zearalenol (Standard) is the analytical standard of β-Zearalenol. This product is intended for research and analytical applications. β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level .
    β-Zearalenol (Standard)

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