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sulfhydryl groups

" in MedChemExpress (MCE) Product Catalog:

45

Inhibitors & Agonists

24

Fluorescent Dye

5

Biochemical Assay Reagents

4

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-121167
    L-Albizziin

    		Glutaminase Cancer
    L-albizziin, as a sulfhydryl group reagent, is a glutamase inhibitor. L-albizziin can be used for the research of cancer .
    L-Albizziin
  • HY-Y1666
    2,2′-Dipyridyl disulfide

    		Biochemical Assay Reagents Others
    2,2′-Dipyridyl disulfide is a useful reagent for the determination of sulfhydryl groups. 2,2′-Dipyridyl disulfide is a common reagent in peptide chemistry, often used in oxidation–reduction condensations to form peptide bonds or in coupling reactions to form disulfide-linked heterodimers .
    2,2′-Dipyridyl disulfide
  • HY-119970
    Helenalin
    5 Publications Verification

    		 NF-κB Inflammation/Immunology Cancer
    Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .
    Helenalin
  • HY-100216
    SPDP
    5 Publications Verification

    SPDP Crosslinker; Py-ds-Prp-OSu

    		 ADC Linker Cancer
    SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) .
    SPDP
  • HY-128925
    AMAS
    1 Publications Verification

    		 ADC Linker Cancer
    AMAS is a nonclaevable heterobifunctional crosslinker with NHS ester and maleimide groups that allows covalent conjugation of amine- and sulfhydryl-containing molecules.
    AMAS
  • HY-D0975
    Sulfo-SMCC sodium
    4 Publications Verification

    		 ADC Linker Cancer
    Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
    Sulfo-SMCC sodium
  • HY-D1618
    Cyanine3 maleimide tetrafluoroborate

    		Fluorescent Dye Others
    Cyanine3 maleimide tetrafluoroborate is a specific labeling reagent for sulfhydryl groups with the λex of 550 nm and λem of 580 nm. Cyanine3 maleimide tetrafluoroborate can be used for protein and peptide labeling .
    Cyanine3 maleimide tetrafluoroborate
  • HY-D1654
    BDP 581/591 maleimide

    		Fluorescent Dye Others
    BDP 581/591 maleimide is a linker of the BDP 581/591 dye. It has a long fluorescence lifetime and can be used for fluorescence polarization assays. The maleimide group can react with thiol groups to form thioester bonds between pH 6.5 to 7.5, for the labeling of sulfhydryl groups of proteins and peptides.
    BDP 581/591 maleimide
  • HY-D2182
    Preactivated PE-Cy5 Maleimide

    		Fluorescent Dye Others
    Preactivated PE-Cy5 Maleimide is a sulfhydryl reactive dye that reacts with free sulfhydryl groups on proteins. Preactivated APC-Cy5.5 Maleimide binds easily to proteins or antibodies, and does not change the spectral characteristics of APC-Cy/YF after activation.
    Preactivated PE-Cy5 Maleimide
  • HY-D2180
    Preactivated APC-Cy5.5 Maleimide

    		Fluorescent Dye Others
    Preactivated APC-Cy5.5 Maleimide is a sulfhydryl reactive dye that reacts with free sulfhydryl groups on proteins. Preactivated APC-Cy5.5 Maleimide binds easily to proteins or antibodies, and does not change the spectral characteristics of APC-Cy/YF after activation.
    Preactivated APC-Cy5.5 Maleimide
  • HY-W888514
    mPEG-CHO

    mPEG-propionaldehyde

    		 Biochemical Assay Reagents Others
    mPEG-CHO (mPEG-propionaldehyde) is a polyethylene glycol (PEG) derivative with a propionaldehyde group. Propionaldehyde is a highly reactive functional group that can covalently bind to amino, sulfhydryl and other functional groups .
    mPEG-CHO
  • HY-W698574
    Dansylamidoethyl mercaptan

    		Biochemical Assay Reagents
    Dansylamidoethyl mercaptan is a molecule that reacts with -SH groups of proteins and other sulfhydryl-containing molecules and has activity for detecting SS bonds in proteins.
    Dansylamidoethyl mercaptan
  • HY-N7594
    Senecionine acetate

    O-Acetylsenecionine

    		 Mitochondrial Metabolism Others
    Senecionine acetate (O-Acetylsenecionine) is a pyrrolizidine alkaloid. Senecionine acetate inhibits the sequestration of Ca 2+ in extramitochondrial and mitochondrial compartments possibly by inactivating free sulfhydryl groups .
    Senecionine acetate
  • HY-126493
    DM4-SPDP

    		Drug-Linker Conjugates for ADC Microtubule/Tubulin Cancer
    DM4-SPDP is a agent-linker conjugate composed of a potent antitubulin agent DM4 and a linker SMCC to make antibody agent conjugate . SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls .
    DM4-SPDP
  • HY-135233
    N-Succinimidyl-S-acetylthioacetate

    SATA

    		 Biochemical Assay Reagents Others
    N-Succinimidyl S-acetylthioacetate (SATA), a protein modification agent, introduces thiol-groups into protein molecules. N-Succinimidyl S-acetylthioacetate adds sulfhydryl groups to proteins and other amine-containing molecules in a protected form .
    N-Succinimidyl-S-acetylthioacetate
  • HY-141540
    Lactyl-CoA

    		Endogenous Metabolite Others
    Lactyl-CoA is an acyl-CoA formally condensed from the sulfhydryl group of CoA and the carboxyl group of lactic acid, also known as lactyl-CoA. Lactyl-CoA is essential for the biosynthesis of biodegradable and biocompatible lactic acid-based copolymers .
    Lactyl-CoA
  • HY-129655
    Sulfo-SMPB sodium

    		ADC Linker Cancer
    Sulfo-SMPB sodium is a non-cleavable, heterobifunctional chemical cross-linking reagent which contains N-hydroxysuccinimide (NHS) ester and maleimide groups, allowing covalent conjugation of amine- and sulfhydryl-containing molecules .
    Sulfo-SMPB sodium
  • HY-D1869
    800CW maleimide

    		Fluorescent Dye Others
    800CW maleimide is an infrared dye that can be used for labeling molecules that contain free sulfhydryl (–SH) groups (Ex: 778 nm; Em: 796 nm). 800CW maleimide binds to plasma proteins .
    800CW maleimide
  • HY-129748
    SQ-24798

    		Carboxylesterase Others
    SQ-24,798 is a compound that inhibits carboxypeptidase B with high affinity and specificity. Its inhibitory effect may be achieved through the binding of the sulfhydryl group to the zinc ion of the enzyme and specific side chains.
    SQ-24798
  • HY-129654
    MTSES sodium

    Sodium (2-Sulfonatoethyl)methanethiosulfonate

    		 Others Others
    MTSES sodium (Sodium (2-Sulfonatoethyl)methanethiosulfonate) is a negatively charged, membrane-impermeable methanethiosulfonate (MTS). MTS is a compound that reacts with sulfhydryl groups to form mixed disulfide bonds and is often used to study cysteine ??residues on proteins.
    MTSES sodium
  • HY-78961
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester

    EMCS

    		 ADC Linker Cancer
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester (EMCS) is a heterobifunctional cross-linking reagent. EMCS is used as a unique and useful reagent for preparation of hapten conjugate and enzyme immunoconjugates .
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester
  • HY-D1730
    AF488 NHS ester

    		Fluorescent Dye Others
    AF488 NHS ester is an amine specific fluorescence probe (Em=525 nm). AF488 NHS ester reacts with sulfhydryl groups and amines in aqueous and biological samples then change their chemical structure and fluorescence properties after derivatization .
    AF488 NHS ester
  • HY-D2094
    PerCP Maleimide

    		Fluorescent Dye Inflammation/Immunology Cancer
    PerCP Maleimide is a fluorescent dye that reacts with free sulfhydryl groups on proteins. PerCP is a red fluorescence albuminous dye for immunostaining and Maleimide can be leveraged for the preparation of fluorogenic probe, which is mainly used for the specific detection of thiol analytes .
    PerCP Maleimide
  • HY-N6773
    Cytochalasin A

    		HIV Protease Fungal Infection
    Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .
    Cytochalasin A
  • HY-D1260
    FM-red

    PSH-red

    		 Fluorescent Dye Neurological Disease
    FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx) .
    FM-red
  • HY-157920
    Biotin-PE-maleimide

    N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine

    		 Biochemical Assay Reagents Others
    Biotin-PE-maleimide (N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine) is a bulky, membrane-impermeable, sulfhydryl-containing reagent with a relatively large molecular size. Biotin-PE-maleimide can be used for biotin labeling (such as thiol groups) and detection of proteins or other biomolecules .
    Biotin-PE-maleimide
  • HY-D0843S
    N-Ethylmaleimide-d5

    NEM-d5

    		 Cathepsin Deubiquitinase Others
    N-Ethylmaleimide-d5 is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor[1]. N-ethylmaleimide specific inhibits phosphate transport in mitochondria[2]. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor[3].
    N-Ethylmaleimide-d5
  • HY-D1363
    BDP R6G maleimide

    		Fluorescent Dye Others
    BDP R6G maleimide is a borodipyrromethane fluorophore with absorption and emission wavelengths similar to those of R6G rhodamine. Sulfhydryl labelling is a common protein modification where the cysteine residues in the protein allow more site-specific labelling than the NHS ester of the amine group. BDP R6G maleimide is a thiol reactive dye that reacts with thiol groups to form thioester bonds .
    BDP R6G maleimide
  • HY-D1730A
    AF488 NHS ester TEA
    1 Publications Verification

    		 Fluorescent Dye Others
    AF488 NHS ester TEA is an amine specific fluorescence probe (λem=525 nm=525 nm). AF488 NHS ester reacts with sulfhydryl groups and amines in aqueous and biological samples then change their chemical structure and fluorescence properties after derivatization. AF488 exhibits the λem and λex wavelength of 520 nm and 470 nm, respectively .
    AF488 NHS ester TEA
  • HY-D2509
    Cy3-PEG-SH (MW 1000)

    		Fluorescent Dye Others
    Cy3-PEG-SH (MW 1000) is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds .
    Cy3-PEG-SH (MW 1000)
  • HY-D2512
    Cy3-PEG-SH (MW 5000)

    		Fluorescent Dye Others
    Cy3-PEG-SH (MW 5000) is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds .
    Cy3-PEG-SH (MW 5000)
  • HY-D2531
    Cy5-PEG-SH (MW 5000)

    		Fluorescent Dye Others
    Cy5-PEG-SH (MW 5000) is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
    Cy5-PEG-SH (MW 5000)
  • HY-D2532
    Cy5-PEG-SH (MW 10000)

    		Fluorescent Dye Others
    Cy5-PEG-SH (MW 10000) is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
    Cy5-PEG-SH (MW 10000)
  • HY-D2530
    Cy5-PEG-SH (MW 3400)

    		Fluorescent Dye Others
    Cy5-PEG-SH (MW 3400) is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
    Cy5-PEG-SH (MW 3400)
  • HY-D2529
    Cy5-PEG-SH (MW 2000)

    		Fluorescent Dye Others
    Cy5-PEG-SH (MW 2000) is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
    Cy5-PEG-SH (MW 2000)
  • HY-15917A
    L-Dithiothreitol
    1 Publications Verification

    		 Biochemical Assay Reagents Others
    L-Dithiothreitol (DTT) is a reducing agent commonly used in various biochemical applications to break disulfide bonds in proteins, thereby denaturing proteins or preventing the formation of unwanted aggregates. DTT has a unique chemical property that cleaves the sulfur-sulfur bond in the disulfide bond to form a sulfhydryl group. This makes it a useful tool for protein purification, enzyme assays, and protein structure studies.
    L-Dithiothreitol
  • HY-D2557
    Cy5.5-PEG-SH (MW 3400)

    		Fluorescent Dye Others
    Cy5.5-PEG-SH (MW 3400) is a fluorescent labeling reagent that combines Cy5.5 (HY-D0924) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
    Cy5.5-PEG-SH (MW 3400)
  • HY-D2559
    Cy5.5-PEG-SH (MW 10000)

    		Fluorescent Dye Others
    Cy5.5-PEG-SH (MW 10000) is a fluorescent labeling reagent that combines Cy5.5 (HY-D0924) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
    Cy5.5-PEG-SH (MW 10000)
  • HY-D2558
    Cy5.5-PEG-SH (MW 5000)

    		Fluorescent Dye Others
    Cy5.5-PEG-SH (MW 5000) is a fluorescent labeling reagent that combines Cy5.5 (HY-D0924) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
    Cy5.5-PEG-SH (MW 5000)
  • HY-D2556
    Cy5.5-PEG-SH (MW 1000)

    		Fluorescent Dye Others
    Cy5.5-PEG-SH (MW 1000) is a fluorescent labeling reagent that combines Cy5.5 (HY-D0924) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
    Cy5.5-PEG-SH (MW 1000)
  • HY-D2448
    Cy3-PEG-Thiol

    		Fluorescent Dye Cancer
    Cy3-PEG-Thiol (Cy3-PEG-SH) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG-Thiol is absorbed at 550nm and has high solubility and end-group substitution rate .
    Cy3-PEG-Thiol
  • HY-D2511
    Cy3-PEG-SH (MW 3400)

    		Fluorescent Dye Cancer
    Cy3-PEG-SH (MW 3400) (Cy3-PEG-Thiol) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG-SH (MW 3400) is absorbed at 550nm and has high solubility and end-group substitution rate .
    Cy3-PEG-SH (MW 3400)
  • HY-D2513
    Cy3-PEG-SH (MW 10000)

    		Fluorescent Dye Cancer
    Cy3-PEG-SH (MW 10000) (Cy3-PEG-Thiol) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG-SH (MW 10000) is absorbed at 550nm and has high solubility and end-group substitution rate .
    Cy3-PEG-SH (MW 10000)
  • HY-D2510
    Cy3-PEG-SH (MW 2000)

    		Fluorescent Dye Cancer
    Cy3-PEG-SH (MW 2000) (Cy3-PEG-Thiol) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG-SH (MW 2000) is absorbed at 550nm and has high solubility and end-group substitution rate .
    Cy3-PEG-SH (MW 2000)
  • HY-66019
    FITC
    Maximum Cited Publications
    49 Publications Verification

    Fluorescein 5-isothiocyanate

    		 Fluorescent Dye Inflammation/Immunology
    FITC (Fluorescein Isothiocyanate), is one of the green fluorescein derivatives widely used in biology. FITC has the characteristics of high absorptivity and excellent fluorescence quantum yield. The isothiocyanate group of FITC can be combined with amino, sulfhydryl, imidazole, tyrosyl, carbonyl and other groups on the protein, so as to achieve protein labeling including antibodies and lectins. In addition to its use as a protein marker, FITC can also be used as a fluorescent protein tracer to rapidly identify pathogens by labeling antibodies, or for microsequencing of proteins and peptides (HPLC). The maximum excitation wavelength of FITC is 494 nm. Once excited, it fluoresces yellow-green at a maximum emission wavelength of 520 nm. In addition, FITC is also a hapten that can induce contact hypersensitivity (CHS) and induce an atopic dermatitis model .
    FITC

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