2. Anti-infection Metabolic Enzyme/Protease
  3. HIV Protease Fungal
  4. Cytochalasin A

Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives.

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Cytochalasin A Chemical Structure

Cytochalasin A Chemical Structure

CAS No. : 14110-64-6

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Cytochalasin A Related Antibodies

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Description

Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives[1][2].

IC50 & Target

HIV-1 protease[1]
Molecular Weight

477.59

Formula

C29H35NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@H]([C@@]([C@@]12[C@](/C=C/C[C@H](C)CCCC(/C=C/C(O1)=O)=O)([H])[C@@H]3O)([H])[C@@H](NC2=O)CC4=CC=CC=C4)C3=C
Structure Classification
Initial Source

strains of Phoma exigua var. exigua
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (209.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0938 mL 10.4692 mL 20.9385 mL
5 mM 0.4188 mL 2.0938 mL 4.1877 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.61%

SDS (643 KB)

COA (254 KB) HNMR (121 KB) RP-HPLC (946 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0938 mL 10.4692 mL 20.9385 mL 52.3462 mL
5 mM 0.4188 mL 2.0938 mL 4.1877 mL 10.4692 mL
10 mM 0.2094 mL 1.0469 mL 2.0938 mL 5.2346 mL
15 mM 0.1396 mL 0.6979 mL 1.3959 mL 3.4897 mL
20 mM 0.1047 mL 0.5235 mL 1.0469 mL 2.6173 mL
25 mM 0.0838 mL 0.4188 mL 0.8375 mL 2.0938 mL
30 mM 0.0698 mL 0.3490 mL 0.6979 mL 1.7449 mL
40 mM 0.0523 mL 0.2617 mL 0.5235 mL 1.3087 mL
50 mM 0.0419 mL 0.2094 mL 0.4188 mL 1.0469 mL
60 mM 0.0349 mL 0.1745 mL 0.3490 mL 0.8724 mL
80 mM 0.0262 mL 0.1309 mL 0.2617 mL 0.6543 mL
100 mM 0.0209 mL 0.1047 mL 0.2094 mL 0.5235 mL
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Cytochalasin A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cytochalasin A14110-64-6HIV ProteaseFungalInhibitorinhibitorinhibit

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