Search Result
Results for "
sulfone
" in MedChemExpress (MCE) Product Catalog:
6
Biochemical Assay Reagents
25
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-W008614
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AG-1813
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Drug Metabolite
Proton Pump
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Metabolic Disease
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Lansoprazole sulfone (AG-1813) is an orally active and selective inhibitor of H +, K +-ATPase. Lansoprazole sulfone can significantly stimulates gastric acid secretion by inhibiting H +, K +-ATPase. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .
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- HY-140601
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PROTAC Linkers
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Cancer
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Sulfone-Bis-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-W008614R
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Drug Metabolite
Proton Pump
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Metabolic Disease
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Lansoprazole sulfone (Standard) is the analytical standard of Lansoprazole sulfone. This product is intended for research and analytical applications. Lansoprazole sulfone (AG-1813) is an orally active and selective inhibitor of H+, K+-ATPase. Lansoprazole sulfone can significantly stimulates gastric acid secretion by inhibiting H+, K+-ATPase. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .
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- HY-137802
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S-Adenosyl-L-homocysteine sulfone
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Others
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Others
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SAHO2 is the sulfone form of the methyl donor S-(5'-adenosyl)-L-methionine chloride (SAM) and serves as a substrate for radical SAM enzymes .
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- HY-142751S
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- HY-143991S
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- HY-144167S
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- HY-Y1314S
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- HY-B1787S
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- HY-136451S
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- HY-B1787
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mTOR
Drug Metabolite
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Cancer
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Sulindac sulfone is an mTORC1 pathway inhibitor and a metabolite of Sulindac. Sulindac sulfone inhibits colon cancer cell growth and induces cell cycle arrest. Sulindac sulfone is used in cancer research .
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- HY-17530
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Cholinesterase (ChE)
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Others
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Aldicarb sulfone(Temik sulfone) is a carbamate insecticide; is a cholinesterase inhibitor which prevents the breakdown of acetylcholine in the synapse.
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- HY-W011239R
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Parasite
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Infection
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Fenbendazole sulfone (Standard) is the analytical standard of Fenbendazole sulfone. This product is intended for research and analytical applications. Fenbendazole sulfone (Oxfendazole sulfone;FBZ-SO2) is a minor metabolite of Fenbendazole in plasma and is a benzimidazole anthelmintic agent .
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- HY-113268R
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Endogenous Metabolite
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Metabolic Disease
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Biotin sulfone (Standard) is the analytical standard of Biotin sulfone. This product is intended for research and analytical applications. Biotin sulfone is first isolated as a natural metabolite of biotin.
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- HY-W019773S1
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- HY-W011239
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Oxfendazole sulfone; FBZ-SO2
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Parasite
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Infection
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Fenbendazole sulfone (Oxfendazole sulfone;FBZ-SO2) is a minor metabolite of Fenbendazole in plasma and is a benzimidazole anthelmintic agent .
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- HY-17008R
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Parasite
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Infection
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Toltrazuril (sulfone) (Standard) is the analytical standard of Toltrazuril (sulfone). This product is intended for research and analytical applications. Toltrazuril sulfone (Ponazuril) is a metabolite of Toltrazuril (HY-B0175), with antiprotozoal activity. Toltrazuril sulfone is a triazine anticoccidial that is developed to prevent coccidiosis in poultry .
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- HY-W019773S
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- HY-146485S
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- HY-17530R
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Cholinesterase (ChE)
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Others
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Aldicarb (sulfone) (Standard) is the analytical standard of Aldicarb (sulfone). This product is intended for research and analytical applications.
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- HY-G0007R
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Drug Metabolite
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Infection
Cancer
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Omeprazole sulfone (Standard) is the analytical standard of Omeprazole sulfone. This product is intended for research and analytical applications.
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- HY-W019773R
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Parasite
Drug Metabolite
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Infection
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Albendazole sulfone (Standard) is the analytical standard of Albendazole sulfone. This product is intended for research and analytical applications. Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes .
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- HY-125296S
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- HY-W587559
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- HY-137306
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- HY-Y1314R
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Drug Metabolite
Endogenous Metabolite
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Metabolic Disease
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Dimethyl sulfone (Standard) is the analytical standard of Dimethyl sulfone. This product is intended for research and analytical applications. Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective .
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- HY-G0007S
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Omeprazole sulfone-d3; Omeprazole sulphone-d3
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Isotope-Labeled Compounds
Drug Metabolite
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Infection
Cancer
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Omeprazole metabolite Omeprazole sulfone-d3 is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.
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- HY-125296R
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GABA Receptor
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Neurological Disease
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Fipronil sulfone (Standard) is the analytical standard of Fipronil sulfone. This product is intended for research and analytical applications. Fipronil sulfone is the major metabolite of Fipronil.Fipronil sulfone selectively inhibits GABA receptor with IC50 of 175 nM (assayed by displacement of 4′-ethynyl-4-n-[2,3-3H2]- propylbicycloorthobenzoate ([3H]EBOB) from the noncompetitive blocker site).
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- HY-W743691
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- HY-113268
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- HY-17008
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Ponazuril
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Parasite
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Infection
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Toltrazuril sulfone (Ponazuril) is a metabolite of Toltrazuril (HY-B0175), with antiprotozoal activity. Toltrazuril sulfone is a triazine anticoccidial that is developed to prevent coccidiosis in poultry .
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- HY-W097491
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- HY-17530S
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- HY-Y1314
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Drug Metabolite
Endogenous Metabolite
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Metabolic Disease
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Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective .
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- HY-W654190
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- HY-125296
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GABA Receptor
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Neurological Disease
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Fipronil sulfone is the major metabolite of Fipronil.Fipronil sulfone selectively inhibits GABA receptor with IC50 of 175 nM (assayed by displacement of 4′-ethynyl-4-n-[2,3-3H2]- propylbicycloorthobenzoate ([3H]EBOB) from the noncompetitive blocker site).
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- HY-146481S
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- HY-138199S1
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- HY-W008614S
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AG-1813-d4
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Isotope-Labeled Compounds
Proton Pump
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Others
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Lansoprazole sulfone-d4 (AG-1813-d4) is the deuterium labeled Lansoprazole sulfone. Lansoprazole sulfone-d4 is an orally active and selective inhibitor of H +, K +-ATPase. Lansoprazole sulfone-d4 can significantly stimulates gastric acid secretion by inhibiting H +, K +-ATPase. Lansoprazole sulfone-d4 has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .
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- HY-W019773
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Parasite
Drug Metabolite
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Infection
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Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes .
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- HY-G0007
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- HY-14774S1
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nAChR
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Cancer
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(Rac)-Monepantel sulfone-d5 is deuterium labeled Monepantel. Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.
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- HY-B0113S2
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Omeprazole sulfone (methoxy-d3); Omeprazole sulphone (methoxy-d3)
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Isotope-Labeled Compounds
Drug Metabolite
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Infection
Cancer
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Omeprazole metabolite Omeprazole sulfone (methoxy-d3) is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.
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- HY-W123001
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- HY-G0007S1
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- HY-138199S
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- HY-148051
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- HY-138753
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PROTAC Linkers
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Cancer
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Bis-sulfone-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Bis-sulfone-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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- HY-138747
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PROTAC Linkers
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Cancer
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Bis-sulfone-PEG4-Tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Bis-sulfone-PEG4-Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-140513
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PROTAC Linkers
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Cancer
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Active-mono-sulfone-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140610
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PROTAC Linkers
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Cancer
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Propargyl-PEG4-Sulfone-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Propargyl-PEG4-Sulfone-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-138745
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ADC Linker
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Cancer
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Bis-sulfone-PEG3-Azide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bis-sulfone-PEG3-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-140607
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PROTAC Linkers
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Cancer
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m-PEG3-Sulfone-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140605
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PROTAC Linkers
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Cancer
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m-PEG3-Sulfone-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140611
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PROTAC Linkers
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Cancer
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Propargyl-peg3-sulfone-peg3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Propargyl-peg3-sulfone-peg3-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-140608
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PROTAC Linkers
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Cancer
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m-PEG3-Sulfone-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . m-PEG3-Sulfone-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-140612
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PROTAC Linkers
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Cancer
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Propargyl-PEG4-Sulfone-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Propargyl-PEG4-Sulfone-PEG4-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-140602
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PROTAC Linkers
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Cancer
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Azido-PEG3-Sulfone-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG3-Sulfone-PEG4-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-140609
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PROTAC Linkers
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Cancer
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m-PEG3-Sulfone-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140613
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PROTAC Linkers
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Cancer
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Boc-PEG4-sulfone-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140606
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PROTAC Linkers
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Cancer
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m-PEG3-Sulfone-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . m-PEG3-Sulfone-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-140604
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PROTAC Linkers
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Cancer
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Azido-PEG3-Sulfone-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG3-Sulfone-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-140603
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PROTAC Linkers
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Cancer
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Azide-PEG3-Sulfone-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azide-PEG3-Sulfone-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-112349
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p38 MAPK
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Inflammation/Immunology
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SB 203580 sulfone is an analog of p38 MAP kinase inhibitor SB 203580, which inhibits the IL-1 production in monocytes with an IC50 of 0.2 μM and binds competitively with CSAID binding proteins (CSBP), inhibits it mediated stress response signaling with an IC50 of 0.03 μM .
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- HY-W011927
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Bisphenol S; Bis(4-hydroxyphenyl) sulfone
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Biochemical Assay Reagents
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Others
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4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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- HY-B0688
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Dapsone
1 Publications Verification
4,4′-Diaminodiphenyl sulfone; DDS
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Antibiotic
Parasite
Bacterial
Reactive Oxygen Species
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Infection
Inflammation/Immunology
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Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .
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- HY-113840
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Ro 14-9706
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Others
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Metabolic Disease
Inflammation/Immunology
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Sumarotene (Ro 14-9706), an arotinoid methyl sulfone, is a potent dermatologic agent for the repair of photodamage, antikeratinization, and antiproliferation. Sumarotene exhibits in rats a prolactin-suppressive activity which affects lactation .
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- HY-162121
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Others
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Cancer
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Antitumor agent-129 (Compound 68) is a thiazolidin-4-one sulfone derivative and an Osteosarcoma (OS) inhibitor with an IC50 value of 0.217 μM, a half-life of 73.8 min (mouse liver microsome) and an excellent pharmacokinetic profile (in vivo bioavailability F = 115%, intraperitoneal administration). Antitumor agent-129 is a potential candidate for OS research .
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- HY-156579
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DNA/RNA Synthesis
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Cancer
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WRN inhibitor 3 (example 110), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor. WRN inhibitor 3 can be used for the research of cancer .
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- HY-156580
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DNA/RNA Synthesis
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Cancer
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WRN inhibitor 4 (example 107), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor. WRN inhibitor 4 can be used for the research of cancer .
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- HY-156581
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DNA/RNA Synthesis
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Cancer
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WRN inhibitor 5 (example 157), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor. WRN inhibitor 5 can be used for the research of cancer .
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- HY-B0688S1
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4,4′-Diaminodiphenyl sulfone-d4; DDS-d4
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Antibiotic
Parasite
Bacterial
Reactive Oxygen Species
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Infection
Inflammation/Immunology
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Dapsone-d4 is the deuterium labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].
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- HY-B0688S2
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4,4′-Diaminodiphenyl sulfone-13C12; DDS-13C12
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Isotope-Labeled Compounds
Antibiotic
Parasite
Bacterial
Reactive Oxygen Species
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Infection
Inflammation/Immunology
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Dapsone- 13C12 is the 13C12 labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .
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- HY-120425
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Others
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Infection
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Ethiprole is an insecticide.Metabolic sulfones are produced faster than Fipronil (HY-B0822) in CYP3A4-expressing cells and in vivo in mouse brain and liver.Ethiprole's sulfide, sulfoxide, sulfone and desulfinyl derivatives have better biological activity .
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- HY-129969
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5-Hydroxylansoprazole sulfone
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Others
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Others
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AG-1909 is an active compound.
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- HY-120425R
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Others
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Infection
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Ethiprole (Standard) is the analytical standard of Ethiprole. This product is intended for research and analytical applications. Ethiprole is an insecticide.Metabolic sulfones are produced faster than Fipronil (HY-B0822) in CYP3A4-expressing cells and in vivo in mouse brain and liver.Ethiprole's sulfide, sulfoxide, sulfone and desulfinyl derivatives have better biological activity .
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- HY-A0241
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RP54476
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Bacterial
Antibiotic
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Infection
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Dalfopristin (RP54476) is a semisynthetic sulfone antibiotic. Dalfopristin alone has limited antibacterial activity, but synergistically with Quinupristin it has significant bactericidal activity against many pathogenic Gram-positive cocci .
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- HY-136438
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- HY-125273
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Others
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Others
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DNS-pE is a vinyl sulfone-based fluorescent probe that has the activity to selectively label 3-phosphoglycerate dehydrogenase (PHGDH) in living mammalian cells and generate fluorescence after labeling, while having inhibitory properties comparable to those of known inhibitors.
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- HY-161337
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Pyruvate Kinase
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Metabolic Disease
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PKL-IN-1 is a potent inhibitor of pyruvate kinase (PKL) with an IC50 of 0.07 μM. PKL-IN-1 can be used in the study of non-alcoholic fatty liver disease .
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- HY-129225
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Others
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Cancer
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WRR139 is a peptide vinyl sulfone involving in disease processes such as inflammation and cancer. WRR139 is also a cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1 inhibitor. WRR139 enhances Carfilzomib cytotoxicity against cancer cells .
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- HY-34444S
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Bondelane A-d8; Cyclic tetramethylene sulfone-d8; Cyclotetramethylene sulfone-d8
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Isotope-Labeled Compounds
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Others
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1,1-Dioxothiolan-d8 is the deuterium labeled 1,1-Dioxothiolan[1].
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- HY-147516
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SARS-CoV
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Infection
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SARS-CoV-2-IN-21 (compound 10), a penicillin sulfone benzyl C6 derivative, is a potent SARS-CoV-2 main protease inhibitor, with an IC50 of 5.3 μM. SARS-CoV-2-IN-21 can be used for COVID-19 research .
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- HY-128777
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VDAC
Apoptosis
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Cancer
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WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX .
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- HY-136438R
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Endogenous Metabolite
Parasite
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Metabolic Disease
Inflammation/Immunology
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Toltrazuril sulfoxide (Standard) is the analytical standard of Toltrazuril sulfoxide. This product is intended for research and analytical applications. Toltrazuril sulfoxide is a short-lived intermediary metabolite of Toltrazuril (HY-B0175), and then can be metabolized to the reactive toltrazuril sulfone (TZR-SO2) in vivo. Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites .
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- HY-W011927R
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Biochemical Assay Reagents
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Others
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4,4'-Sulfonyldiphenol (Standard) is the analytical standard of 4,4'-Sulfonyldiphenol. This product is intended for research and analytical applications. 4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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- HY-W440905
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Biochemical Assay Reagents
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Others
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DSPE-PEG-Vinylsulfone, MW 2000 is a phospholipid PEG which can self-assemble to form lipid bilayer in water. The polymer can be used to encapsulate therapeutics, such as nucleic acid (mRNA/DNA) or protein, in drug delivery system. The vinyl sulfone is reactive with thiol molecule via thiol-ene reaction for bioconjugation. Reagent grade, for research use only.
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- HY-W440904
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Biochemical Assay Reagents
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Others
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DSPE-PEG-Vinylsulfone, MW 1000 is a self-assembling PEG reagent which forms lipid bilayer. The amphiphilic polymer can be used to prepare liposome for delivering therapeutics, such as nucleic acid (mRNA/DNA) or protein. The vinyl sulfone moiety is reactive with cysteine or other thiol molecule via thiol-ene chemistry. Reagent grade, for research use only.
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- HY-W440907
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Biochemical Assay Reagents
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Others
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DSPE-PEG-Vinylsulfone, MW 5000 is a viniyl sulfone PEG lipid which can be used for bioconjugation with cysteine or other thiol molecule through thiol-ene reaction. The polymer is a self-assembling reagetn which forms lipid bilayer in water and can be used as drug carrier to delivery therapeutic agents, such as mRNA or DNA vaccine. Reagent grade, for research use only.
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- HY-B0688S
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4,4′-Diaminodiphenyl sulfone-d8; DDS-d8
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Antibiotic
Parasite
Bacterial
Reactive Oxygen Species
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Infection
Inflammation/Immunology
Cancer
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Dapsone-d8 is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].
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- HY-161762
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Virus Protease
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Infection
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RA-0002034 is a Chikungunya virus (CHIKV) nsP2 protease inhibitor with an IC50 of 58 nM. RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner .
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- HY-B0688R
-
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Antibiotic
Parasite
Bacterial
Reactive Oxygen Species
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Infection
Inflammation/Immunology
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Dapsone (Standard) is the analytical standard of Dapsone. This product is intended for research and analytical applications. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .
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-
- HY-128971
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Cathepsin
Parasite
|
Infection
Neurological Disease
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LHVS is a potent, non-selective, irreversible, cell-permeable cysteine protease and cathepsin inhibitor. LHVS decreases actin ring formation. LHVS inhibits T. gondii invasion with an IC50 of 10 μM .
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- HY-168500
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Beta-lactamase
Bacterial
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Infection
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Metallo-β-lactamase-IN-16 (compound 18) is a sulfone containing metallo-β-lactamase inhibitor with an anti-bacterial activity. Metallo-β-lactamase-IN-16 inhibits NDM-1 (New Dehli metallo-β-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona integron-encoded metallo-β-lactamase), and VIM-2 with IC50 values of 0.16 nM, 0.23 nM, 0.31 nM and 1.0 nM, respectively .
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- HY-121195
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PC-904
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Bacterial
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Infection
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Apalcillin (PC-904) in combination with Ro 48-1220, a penam sulfone β-lactamase inhibitor, demonstrated broad-spectrum activity against gram-negative aerobic and anaerobic bacteria, excluding Klebsiella oxytoca. It exhibited potent activity against β-lactamase-producing Moraxella catarrhalis, Haemophilus influenzae, and Neisseria gonorrhoeae, with effective MICs (11 μg/mL). The combination also inhibited Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter species at low MICs (0.25 to 4 μg/mL). However, its efficacy against oxacillin-resistant staphylococci and certain gram-positive organisms was limited. Apalcillin/Ro 48-1220 showed comparable efficacy to piperacillin/tazobactam against some extended-spectrum β-lactamase-producing Escherichia coli but was less effective against SHV-type β-lactamases .
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Cat. No. |
Product Name |
Type |
-
- HY-W011927
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Bisphenol S; Bis(4-hydroxyphenyl) sulfone
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Biochemical Assay Reagents
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4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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- HY-W123001
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- HY-W011927R
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Biochemical Assay Reagents
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4,4'-Sulfonyldiphenol (Standard) is the analytical standard of 4,4'-Sulfonyldiphenol. This product is intended for research and analytical applications. 4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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- HY-W440905
-
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Drug Delivery
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DSPE-PEG-Vinylsulfone, MW 2000 is a phospholipid PEG which can self-assemble to form lipid bilayer in water. The polymer can be used to encapsulate therapeutics, such as nucleic acid (mRNA/DNA) or protein, in drug delivery system. The vinyl sulfone is reactive with thiol molecule via thiol-ene reaction for bioconjugation. Reagent grade, for research use only.
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-
- HY-W440904
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|
Drug Delivery
|
DSPE-PEG-Vinylsulfone, MW 1000 is a self-assembling PEG reagent which forms lipid bilayer. The amphiphilic polymer can be used to prepare liposome for delivering therapeutics, such as nucleic acid (mRNA/DNA) or protein. The vinyl sulfone moiety is reactive with cysteine or other thiol molecule via thiol-ene chemistry. Reagent grade, for research use only.
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-
- HY-W440907
-
|
Drug Delivery
|
DSPE-PEG-Vinylsulfone, MW 5000 is a viniyl sulfone PEG lipid which can be used for bioconjugation with cysteine or other thiol molecule through thiol-ene reaction. The polymer is a self-assembling reagetn which forms lipid bilayer in water and can be used as drug carrier to delivery therapeutic agents, such as mRNA or DNA vaccine. Reagent grade, for research use only.
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Cat. No. |
Product Name |
Target |
Research Area |
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-142751S
-
|
Fenthion sulfone-d6 is the deuterium labeled Fenthion sulfone[1].
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-
-
- HY-143991S
-
|
Modafinil acid sulfone-d5 is the deuterium labeled Modafinil acid sulfone[1].
|
-
-
- HY-144167S
-
|
Methiocarb sulfone-d3 is the deuterium labeled Methiocarb sulfone[1].
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-
-
- HY-Y1314S
-
|
Dimethyl sulfone-d6 is the deuterium labeled Dimethyl sulfone. Dimethyl sulfone is an endogenous metabolite.
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-
-
- HY-B1787S
-
|
Sulindac sulfone-d3 is deuterium labeled Sulindac sulfone.
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-
-
- HY-136451S
-
|
Triclabendazole sulfone-d3 is the deuterium labeled Triclabendazole sulfone.
|
-
-
- HY-W019773S1
-
|
Albendazole sulfone-d3 is the deuterium labeled Albendazole sulfone. Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes.
|
-
-
- HY-W019773S
-
|
Albendazole sulfone-d7 is the deuterium labeled Albendazole sulfone. Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes[1][2].
|
-
-
- HY-146485S
-
|
Fulvestrant-9-sulfone-d3 is the deuterium labeled Fulvestrant-9-sulfone[1].
|
-
-
- HY-125296S
-
|
Fipronil sulfone- 13C6 is the 13C-labeled Fipronil sulfone[1].
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-
-
- HY-G0007S
-
|
Omeprazole metabolite Omeprazole sulfone-d3 is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.
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-
-
- HY-W743691
-
|
2,4'-Dihydroxydiphenyl sulfone-d8 is deuterium-labeled 2,4'-Dihydroxydiphenyl sulfone .
|
-
-
- HY-17530S
-
|
Aldicarb sulfone- 13C2,d3 is the deuterium and 13C labeled Aldicarb sulfone[1].
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-
-
- HY-W654190
-
|
Fipronil sulfone-13C2,15N2 is a deuterated labeled Fipronil sulfone-13C2,15N2 .
|
-
-
- HY-146481S
-
|
Lansoprazole sulfone N-oxide-d4 is the deuterium labeled Lansoprazole sulfone N-oxide[1].
|
-
-
- HY-138199S1
-
|
Omeprazole sulfone N-oxide-d3 is the deuterium labeled Omeprazole sulfone N-Oxide[1].
|
-
-
- HY-W008614S
-
|
Lansoprazole sulfone-d4 (AG-1813-d4) is the deuterium labeled Lansoprazole sulfone. Lansoprazole sulfone-d4 is an orally active and selective inhibitor of H +, K +-ATPase. Lansoprazole sulfone-d4 can significantly stimulates gastric acid secretion by inhibiting H +, K +-ATPase. Lansoprazole sulfone-d4 has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .
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-
-
- HY-14774S1
-
|
(Rac)-Monepantel sulfone-d5 is deuterium labeled Monepantel. Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.
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-
-
- HY-B0113S2
-
|
Omeprazole metabolite Omeprazole sulfone (methoxy-d3) is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.
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-
-
- HY-G0007S1
-
|
Omeprazole metabolite Omeprazole sulfone- 13C,d3 is the deuterium and 13C labeled Omeprazole metabolite Omeprazole sulfone[1].
|
-
-
- HY-138199S
-
|
Omeprazole sulfone N-oxide- 13C,d3 is the deuterium and 13C labeled Omeprazole sulfone N-Oxide[1].
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-
-
- HY-B0688S1
-
|
Dapsone-d4 is the deuterium labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].
|
-
-
- HY-B0688S2
-
|
Dapsone- 13C12 is the 13C12 labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .
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-
-
- HY-34444S
-
|
1,1-Dioxothiolan-d8 is the deuterium labeled 1,1-Dioxothiolan[1].
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-
-
- HY-B0688S
-
|
Dapsone-d8 is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].
|
-
Cat. No. |
Product Name |
|
Classification |
-
- HY-138745
-
|
|
ADC Synthesis
Azide
|
Bis-sulfone-PEG3-Azide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bis-sulfone-PEG3-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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-
- HY-138753
-
|
|
DBCO
PROTAC Synthesis
|
Bis-sulfone-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Bis-sulfone-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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-
- HY-138747
-
|
|
PROTAC Synthesis
Tetrazine
|
Bis-sulfone-PEG4-Tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Bis-sulfone-PEG4-Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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-
- HY-140610
-
|
|
Alkynes
PROTAC Synthesis
|
Propargyl-PEG4-Sulfone-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Propargyl-PEG4-Sulfone-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-140611
-
|
|
PROTAC Synthesis
Alkynes
|
Propargyl-peg3-sulfone-peg3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Propargyl-peg3-sulfone-peg3-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-140608
-
|
|
Alkynes
PROTAC Synthesis
|
m-PEG3-Sulfone-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . m-PEG3-Sulfone-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-140612
-
|
|
PROTAC Synthesis
Alkynes
|
Propargyl-PEG4-Sulfone-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Propargyl-PEG4-Sulfone-PEG4-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-140602
-
|
|
Azide
PROTAC Synthesis
|
Azido-PEG3-Sulfone-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG3-Sulfone-PEG4-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-140606
-
|
|
PROTAC Synthesis
Azide
|
m-PEG3-Sulfone-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . m-PEG3-Sulfone-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-140604
-
|
|
Azide
PROTAC Synthesis
|
Azido-PEG3-Sulfone-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG3-Sulfone-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-140603
-
|
|
Azide
PROTAC Synthesis
|
Azide-PEG3-Sulfone-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azide-PEG3-Sulfone-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
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