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tetrahydroisoquinolines

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Antibiotic (1) Apoptosis (2) Bacterial (2) Drug Derivative (1) Drug Intermediate (2) Endogenous Metabolite (4) Estrogen Receptor/ERR (1) HDAC (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) Monoamine Oxidase (4) nAChR (2) P-selectin (1) Ras (1) Reactive Oxygen Species (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (11)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0137

Tetrahydropapaverine hydrochloride	Drug Intermediate	Neurological Disease
Tetrahydropapaverine hydrochloride is one of the Tetrahydroisoquinolines. Tetrahydropapaverine hydrochloride has neurotoxic effects on dopamine neurons .

HY-N0137A

(R)-Tetrahydropapaverine hydrochloride	Drug Intermediate	Neurological Disease
(R)-Tetrahydropapaverine hydrochloride is the isomer of Tetrahydropapaverine hydrochloride (HY-N0137), and can be used as an experimental control. Tetrahydropapaverine hydrochloride is one of the Tetrahydroisoquinolines. Tetrahydropapaverine hydrochloride has neurotoxic effects on dopamine neurons .

HY-N3610

Coclaurine 1 Publications Verification	nAChR	Neurological Disease
Coclaurine is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist .

HY-101191

Ecteinascidin 770 2 Publications Verification Ecteinascidine 770; Et-770	Apoptosis	Cancer
Ecteinascidin 770 (ET-770) is a 1,2,3,4-tetrahydroisoquinoline alkaloid with potent anti-cancer activities; inhibits U373MG cells with an IC₅₀ of 4.83 nM.

HY-W705106

(-)-Coclaurine hydrochloride (-)-(S)-Coclaurine hydrochloride; (S)-Coclaurine hydrochloride; l-Coclaurine hydrochloride	nAChR	Neurological Disease
(-)-Coclaurine hydrochloride (compound I) is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum. (-)-Coclaurine hydrochloride is a nicotinic acetylcholine receptor (nAChRs) antagonist .

HY-113969

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline	Endogenous Metabolite	Neurological Disease
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a K_i value of 0.3 μM. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease .

HY-156079

Antidepressant agent 5	Monoamine Oxidase	Neurological Disease
Antidepressant agent 5 (Compound 3i) is a 7-substituted tetrahydroisoquinolines derivatives. Antidepressant agent 5 exhibits almost equal antidepressant activity compared with magnoflorine. ntidepressant agent 5 can be used for depressive disorder research .

HY-126804

Safracin B	Antibiotic	Infection Cancer
Safracin B, a tetrahydroisoquinoline (THIQ) alkaloid, is a naturally occurring antibiotic from Pseudomonas fluorescens. Safracin B exhibits broad spectrum antimicrobial and strong antitumor activities .

$Safracin B$

HY-139795

ZYJ-25e	HDAC	Cancer
ZYJ-25e is a potent histone deacetylase inhibitor (HDACi) with IC₅₀s of 0.047 μM and 0.139 μM for HDAC6 and HDAC8, respectively. ZYJ-25e is a tetrahydroisoquinoline-bearing hydroxamic acid analogue. ZYJ-25e shows marked antitumor potency in the MDA-MB231 xenograft model .

HY-148480

Nrf2 activator-6	Keap1-Nrf2	Cardiovascular Disease
Nrf2 activator-6, a tetrahydroisoquinoline compound, is a Nrf2 activator. Nrf2 activator-6 has an IC₅₀ of 5 nM for inhibiting the Kelch domain-Nrf2 interaction (WO2021214470A1; Example 4) .

HY-22385

Salsolidine 2 Publications Verification	Monoamine Oxidase	Neurological Disease
Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor.

HY-22385A

Salsolidine hydrochloride	Monoamine Oxidase	Neurological Disease
Salsolidine hydrochloride, a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A (monoamine oxidase A) inhibitor.

HY-100296

Gastrofensin AN 5 free base	Drug Derivative	Inflammation/Immunology
Gastrofensin AN 5 free base, a 4-phenyl-tetrahydroisoquinoline derivative, is an antiulcer agent.

HY-139570

Ecubectedin PM14	Bacterial	Infection Inflammation/Immunology Cancer
Ecubectedin (PM14) is a derivative. Ecteinascidins is a family of tetrahydroisoquinoline alkaloids with wide range of antitumor and antimicrobial activities .

HY-12395

Ecteinascidin-Analog-1	Bacterial	Cancer
Ecteinascidin-Analog-1 is a useful intermediate for chemical sythesis of Ecteinascidin analogues; Ecteinascidins is a family of tetrahydroisoquinoline alkaloids with wide range of antitumor and antimicrobial activities.

HY-W029659

1-Benzyl-1,2,3,4-tetrahydro-isoquinoline	Endogenous Metabolite	Neurological Disease
1-Benzyl-1,2,3,4-tetrahydro-isoquinoline is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Parkinson's Disease .

HY-22385B

(S)-Salsolidine	Monoamine Oxidase Endogenous Metabolite	Neurological Disease
(S)-Salsolidine is a weak monoamine oxidase (MAO) inhibitor (K_i=63 μM). The R enantiomer of Salsolidine is more potent than the S form (K_i=26 μM) .

HY-129665

GS-389 (±)-O,O-Dimethylcoclaurine	Endogenous Metabolite	Metabolic Disease
GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K ⁺ in rat aortic rings .

HY-147399

5-HT7 agonist 2	5-HT Receptor	Neurological Disease
5-HT7 agonist 2 is a potent 5-HT₇ receptor agonist with an IC₅₀ value of 28.7 nM. 5-HT7 agonist 2 can be used for research of central nervous system (CNS) disorders .

HY-164726

Estrogen receptor modulator 11	Estrogen Receptor/ERR	Others
Estrogen receptor modulator 11 (Compound 27) is a tetrahydroisoquinoline derivative. Estrogen receptor modulator 11 has a certain affinity for estrogen receptors (ER), with IC₅₀ values of 285 nM and 421 nM for ERα and ERβ, respectively. Estrogen receptor modulator 11 lacks antagonist activity in the MCF-7 cellular assay .

HY-138295

KRAS inhibitor-10	Ras	Cancer
KRAS inhibitor-10 (compound 11) selectively and effectively inhibit RAS proteins, and particularly KRAS proteins. KRAS inhibitor-10 is an orally active anti-cancer agent and can be used for cancer research, such as pancreatic cancer, breast cancer, multiple myeloma, leukemia and lung cancer. KRAS inhibitor-10 is a tetrahydroisoquinoline compound (compound 11) extracted from patent WO2021005165 A1 .

HY-50936S

Trabectedin-d3 Ecteinascidin 743-d₃; ET-743-d₃	Isotope-Labeled Compounds Reactive Oxygen Species Apoptosis	Inflammation/Immunology Cancer
Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment .

HY-132828

Odatroltide LT3001; DHDMIQK(KAP)	P-selectin	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Odatroltide (LT3001; DHDMIQK(KAP)) is a P-selectin inhibitor. Odatroltide is a peptide molecule comprising a tripeptide Pro-Ala-Lys (PAK) and an (S)-6,7-dihydroxy-1,1-dimethyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid domain. Odatroltide can restore cerebral blood flow, scavenge free radicals, and inhibit leukocyte migration. Odatroltide possesses thrombolytic and anti-thrombotic activities .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3610

Coclaurine 1 Publications Verification	Alkaloids Structural Classification Source classification Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm.	nAChR
Coclaurine is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist .

HY-101191

Ecteinascidin 770 2 Publications Verification Ecteinascidine 770; Et-770	Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Isoquinoline Alkaloids Disease Research Fields Cancer	Apoptosis
Ecteinascidin 770 (ET-770) is a 1,2,3,4-tetrahydroisoquinoline alkaloid with potent anti-cancer activities; inhibits U373MG cells with an IC₅₀ of 4.83 nM.

HY-22385

Salsolidine 2 Publications Verification	Alkaloids Structural Classification Animals Source classification Isoquinoline Alkaloids	Monoamine Oxidase
Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor.

HY-W705106

(-)-Coclaurine hydrochloride (-)-(S)-Coclaurine hydrochloride; (S)-Coclaurine hydrochloride; l-Coclaurine hydrochloride	Structural Classification Alkaloids Piperidine Alkaloids Source classification Cocculus laurifolius DC. Plants Menispermaceae	nAChR
(-)-Coclaurine hydrochloride (compound I) is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum. (-)-Coclaurine hydrochloride is a nicotinic acetylcholine receptor (nAChRs) antagonist .

HY-113969

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Isoquinoline Alkaloids Disease Research Fields	Endogenous Metabolite
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a K_i value of 0.3 μM. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease .

HY-126804

Safracin B	Infection Quinones Monophenols Microorganisms Classification of Application Fields Source classification Phenols Benzene Quinones Disease Research Fields	Antibiotic
Safracin B, a tetrahydroisoquinoline (THIQ) alkaloid, is a naturally occurring antibiotic from Pseudomonas fluorescens. Safracin B exhibits broad spectrum antimicrobial and strong antitumor activities .

$Safracin B$

HY-22385A

Salsolidine hydrochloride	Alkaloids other families Source classification Plants Isoquinoline Alkaloids	Monoamine Oxidase
Salsolidine hydrochloride, a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A (monoamine oxidase A) inhibitor.

HY-W029659

1-Benzyl-1,2,3,4-tetrahydro-isoquinoline	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Isoquinoline Alkaloids Disease Research Fields	Endogenous Metabolite
1-Benzyl-1,2,3,4-tetrahydro-isoquinoline is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Parkinson's Disease .

HY-22385B

(S)-Salsolidine	Alkaloids Structural Classification Source classification Salsola Plants Isoquinoline Alkaloids Chenopodiaceae	Monoamine Oxidase Endogenous Metabolite
(S)-Salsolidine is a weak monoamine oxidase (MAO) inhibitor (K_i=63 μM). The R enantiomer of Salsolidine is more potent than the S form (K_i=26 μM) .

HY-129665

GS-389 (±)-O,O-Dimethylcoclaurine	Structural Classification Alkaloids Source classification Cocculus laurifolius DC. Plants Isoquinoline Alkaloids Menispermaceae	Endogenous Metabolite
GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K ⁺ in rat aortic rings .

Cat. No.	Product Name	Chemical Structure

HY-50936S

Trabectedin-d3
Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment .

Trabectedin-d3

Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment .

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tetrahydroisoquinolines

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
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