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Results for "

thioether

" in MedChemExpress (MCE) Product Catalog:

28

Inhibitors & Agonists

4

Fluorescent Dye

4

Biochemical Assay Reagents

7

Peptides

2

Natural
Products

1

Click Chemistry

5

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P5963
    Lib2-1

    		Interleukin Related Inflammation/Immunology
    Lib2-1, a macrocyclic peptide, is an IL-17C/IL-17RE interaction inhibitor. Lib2-1 can be used for autoimmune and inflammatory diseases research .
    Lib2-1
  • HY-P3440
    WL12

    		Radionuclide-Drug Conjugates (RDCs) PD-1/PD-L1 Cancer
    WL12 is a specifically targeting programmed death ligand 1 (PD-L1) binding peptide. WL12 can be radiolabeled by different radionuclides, generating radiotracers, which can assess the tumor PD-L1 expression .
    WL12
  • HY-E70277
    Hexadecyl-CoA

    		ATGL Metabolic Disease
    Hexadecyl-CoA is a thioether analog of acyl-CoA that can inhibit adipose triglyceride lipase (ATGL) .
    Hexadecyl-CoA
  • HY-P5984A
    Thioether-cyclized helix B peptide, CHBP TFA

    		mTOR Others
    Thioether-cyclized helix B peptide, CHBP (TFA) is the TFA form of Thioether-cyclized helix B peptide, CHBP (HY-P5984). Thioether-cyclized helix B peptide, CHBP (TFA) can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 .
    Thioether-cyclized helix B peptide, CHBP TFA
  • HY-P5984
    Thioether-cyclized helix B peptide, CHBP

    		mTOR Others
    Thioether-cyclized helix B peptide, CHBP can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 .
    Thioether-cyclized helix B peptide, CHBP
  • HY-P10714
    Ub4ix

    		Proteasome Apoptosis Deubiquitinase Cancer
    Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC50 value of 1.6 μM .
    Ub4ix
  • HY-126781
    Fozivudine tidoxil

    BM-211290

    		 HIV DNA/RNA Synthesis Infection
    Fozivudine tidoxil (BM-211290) is an orally active thioether lipid-zidovudine (ZDV) conjugate with anti-HIV activity. Fozivudine tidoxil, a member of the NRTI family of agent, is incorporated into the newly synthesized strand of DNA during intracellular viral replication and irreversibly binds viral RT which disrupts viral reverse-transcription . Fozivudine tidoxil is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Fozivudine tidoxil
  • HY-P2331
    Actagardin

    Antibiotic A 3802-IV-3; Gardimycin

    		 Antibiotic Infection
    Actagardin is a tetracyclic lantibiotic produced by several species of Actinoplanes. It is composed of macrocyclic rings formed by thioether bridges. Actagardin preferably targets Gram-positive bacteria, inhibiting the synthesis of peptidoglycan.
    Actagardin
  • HY-129846
    IBTP iodide

    		Others Others
    IBTP iodide is a lipophilic cation and can be accumulated by mitochondria and yields stable thioether adducts in a thiol-specific reaction. IBTP iodide can be used for specific labeling of mitochondrial protein thiols .
    IBTP iodide
  • HY-W440995
    DOPE-PEG-Mal (MW 2000)

    		Liposome Cancer
    DOPE-PEG-Mal (MW 2000) is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. It is also reactive with thiol at pH 6.5 tp 7.5 to form a stable thioether bond.
    DOPE-PEG-Mal (MW 2000)
  • HY-W440719
    Cholesterol-PEG-MAL (MW 2000)

    		Liposome Cancer
    Cholesterol-PEG-MAL (MW 2000) is a PEG derivative and can be used to prepare liposome or nanoparticle due to its ability to self-assemble in water. The maleimide moiety is reactive with thiol molecule to form a covalent thioether bond.
    Cholesterol-PEG-MAL (MW 2000)
  • HY-W440727
    Cholesterol-PEG-Vinylsulfone (MW 2000)

    		Liposome Cancer
    Cholesterol-PEG-Vinylsulfone (MW 2000) is a thiol reactive polyPEG via thiol-ene reaction to form a thioether bond. It can self-assemble in water and is used to prepare liposome as drug vehicle for targeted delivery into tissues.
    Cholesterol-PEG-Vinylsulfone (MW 2000)
  • HY-W440722
    Cholesterol-PEG-Thiol (MW 1000)

    		Biochemical Assay Reagents Liposome Others
    Cholesterol-PEG-Thiol (MW 1000) is a PEGylated lipid that forms micelles in water and can be used to prepare liposomes or nanoparticles as drug delivery systems. The thiol moiety reacts with maleimide to form a stable thioether bond .
    Cholesterol-PEG-Thiol (MW 1000)
  • HY-W440724
    Cholesterol-PEG-Thiol (MW 3400)

    		Liposome Cancer
    Cholesterol-PEG-Thiol (MW 3400) is an amphiphatic PEG derivative which forms micelles in water and can be used to prepare liposomes or nanoparticles for drug delivery system. The thiol moiety is reactive with maleimide to form a stable thioether bond.
    Cholesterol-PEG-Thiol (MW 3400)
  • HY-W440896
    DSPE-PEG-SH, MW 2000

    		Liposome Others
    DSPE-PEG-SH, MW 2000 is a pegylated phospholipid with thiol group which is reactive with maleimide to form a covalent thioether linkage. The amphiphatic polymer can form lipid bilayer in aqueous solution and be used to encapsulate agents for drug delivery system, such as mRNA vaccine.
    DSPE-PEG-SH, MW 2000
  • HY-W009749
    L-Cystathionine

    		Endogenous Metabolite Apoptosis Cardiovascular Disease
    L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection .
    L-Cystathionine
  • HY-W009749C
    L-Cystathionine dihydrochloride

    		Endogenous Metabolite Apoptosis Cardiovascular Disease
    L-Cystathionine (dihydrochloride) is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine (dihydrochloride) protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine (dihydrochloride) plays an important role in cardiovascular protection .
    L-Cystathionine dihydrochloride
  • HY-D2497
    Sulfo Cy7 bis-SH

    		Fluorescent Dye Others
    Sulfo Cy7 bis-SH is a fluorescent dye that contains sulfonated Cyanine7 (Sulfo-CY7) fluorescent dye and thiol (-SH) functional group. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds .
    Sulfo Cy7 bis-SH
  • HY-130081
    DM3-SMe

    		ADC Cytotoxin Microtubule/Tubulin Cancer
    DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM .
    DM3-SMe
  • HY-130082
    DM4-SMe

    		ADC Cytotoxin Microtubule/Tubulin Cancer
    DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM .
    DM4-SMe
  • HY-W441003
    DSPE-PEG-IA (MW 2000)

    		Biochemical Assay Reagents Others
    DSPE-PEG-IA, MW 2000 is a thiol reactive phospholipid polyPEG. The iodoacetyll group is reactive with thiol to produce a thioether linkage. The polymer can self-assemble in water to form lipid bilayer and can be used to encapsulate drugs in targeted delivery application, such as liposomal doxorubicin as an anti cancer drug or mRNA vaccine. Reagent grade, for research use only.
    DSPE-PEG-IA (MW 2000)
  • HY-D2509
    Cy3-PEG-SH (MW 1000)

    		Fluorescent Dye Others
    Cy3-PEG-SH (MW 1000) is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds .
    Cy3-PEG-SH (MW 1000)
  • HY-D2512
    Cy3-PEG-SH (MW 5000)

    		Fluorescent Dye Others
    Cy3-PEG-SH (MW 5000) is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds .
    Cy3-PEG-SH (MW 5000)
  • HY-W440902
    DSPE-PEG-IA (MW 3400)

    		Biochemical Assay Reagents Others
    DSPE-PEG-IA, MW 3400 is an iodoacetyll PEG lipid. The polymer can form lipid bilayer or micelles spontaneoulsy in water. The lipophilic tails can be used to encapsulate hydrophobic therapeutic agents while the hydrophilic head can be used to encapuslate hydrophilic drugs/nutrient, such as antibody, mRNA/DNA. The iodoacetyl group is reactive with thiol to produce a thioether linkage. Reagent grade, for research use only.
    DSPE-PEG-IA (MW 3400)
  • HY-161096
    Antitumor agent-127

    		ROR Cancer
    Antitumor agent-127 (compound 1) is a parent macrocyclic peptide. Antitumor agent-127 displays nanomolar cell-based binding to ROR1 and relatively good internalization in 786-O and MDA-MB-231 tumor cell lines .
    Antitumor agent-127
  • HY-149275
    PKM2/PDK1-IN-1

    		Pyruvate Kinase PDK-1 Akt EGFR Apoptosis Cancer
    PKM2/PDK1-IN-1, one of shikonin thioether derivatives, is a dual inhibitor of PKM2/PDK1. PKM2/PDK1-IN-1 inhibits the proliferation of NSCLC cells, and induces apoptosis. PKM2/PDK1-IN-1 induces intercellular ROS production, and regulates the apoptotic proteins, to involves in mitochondrial and death receptor pathway .
    PKM2/PDK1-IN-1
  • HY-W394935
    Dixylyl disulphide

    Disulfide,bis(2,4-dimethylphenyl)

    		 Biochemical Assay Reagents Others
    Dixylyl disulphide (Disulfide, bis(2,4-dimethylphenyl)) is a 1,2-bis(2,4-dimethylphenyl) thioether that can serve as an impurity reference standard for hydrobromide vortioxetine, used for monitoring impurities in the synthesis process. Hydrobromide vortioxetine is a 5-HT3, 5-HT7, and 5-HT1D receptor antagonist and a 5-HT1A receptor agonist, exhibiting antidepressant activity .
    Dixylyl disulphide
  • HY-150087
    Ctrl-CF4-S2

    		Fluorescent Dye Others
    Ctrl-CF4-S2 is a chemically modified control probe of the copper probe Copper Fluor-4 (CF4, HY-150086), in which two of the four thioether ligands in CF4 (HY-150086) are replaced with methylene groups. CF4 (HY-150086) is a fluorescent probe used for detecting the presence and distribution of copper ions, whereas Ctrl-CF4-S2 does not respond to copper ions. This allows it to eliminate background signals from copper, thereby helping to determine whether the signals from CF4 (HY-150086) accurately reflect the dynamic changes of copper ions in biological systems
    Ctrl-CF4-S2

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