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transglutaminase 2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Glutaminase (10) PROTACs (1)
By Research Areas:	Cancer (5) Inflammation/Immunology (4) Metabolic Disease (1)

10

Inhibitors & Agonists

1

Inhibitory Antibodies

3

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

TG-2-IN-1	Glutaminase	Others
TG-2-IN-1 (Compound D003) is a *transglutaminase-2* (TGM-2) inhibitor. TG-2-IN-1 can be used for the research of myopia .

GK921 3 Publications Verification	Glutaminase	Cancer
GK921 is a transglutaminase 2 (TGase) inhibitor with an IC₅₀ of 7.71 μM for human recombinant TGase 2.

KCC009	Glutaminase	Cancer
KCC009, a *transglutaminase 2* (TG2) inhibitor, induces p53-independent radiosensitization .

NTU281	Glutaminase Apoptosis	Metabolic Disease Inflammation/Immunology
NTU281 is a potent *transglutaminase-2* inhibitor. NTU281 can reduce the increases in serum creatinine and albuminuria in diabetic rats. NTU281 can also reduce glomerular collagen I accumulation, Hic-5 and α-SMA expression, and apoptosis. NTU281 can be used for researching glomerulosclerosis caused by diabetes .

AA10	Glutaminase	Cancer
AA10 is a potent and irreversible transglutaminase 2 (TG2) inhibitor for cancer research .

LM11	Glutaminase	Cancer
LM11 is an inhibitor of transglutaminase 2 (TG2) with an activity of killing glioblastoma cells by maintaining TG2 in a cytotoxic conformational state .

Zampilimab UCB-7858	Glutaminase	Inflammation/Immunology
Zampilimab (UCB-7858) is a monoclonal antibody against *transglutaminase 2* (TG2). Zampilimab has potential application in renal transplant .

TG-2-IN-4	Glutaminase	Inflammation/Immunology
TG-2-IN-4 (compound 8) is a transglutaminase 2 (TG2) inhibitor with an IC₅₀ <0.5 mM. TG-2-IN-4 can be used for the research of inflammatory disorder .

ZED-1227	Glutaminase	Inflammation/Immunology
ZED-1227 is a specific and orally active transglutaminase 2 (TG2) inhibitor, with an IC₅₀ of 45 nM. ZED-1227 can block inflammation-induced TG2 expression and activity. ZED-1227 can be used for the research of celiac disease (CeD) .

PROTAC TG2 degrader-2	PROTACs Glutaminase	Cancer
PROTAC TG2 degrader-2 (compound 7) is a selective, competitive degrader targeting *Transglutaminase 2* (TG2), with K_d > 100 μM. PROTAC TG2 degrader-2 inhibits the cell migration and decreases the level of TG2 in ovarian cancer cells. PROTAC TG2 degrader-2 can be used for ovarian cancer study .

Cat. No.	Product Name	Target	Research Area

Zampilimab UCB-7858	Glutaminase	Inflammation/Immunology
Zampilimab (UCB-7858) is a monoclonal antibody against *transglutaminase 2* (TG2). Zampilimab has potential application in renal transplant .

Species:	Human (1) Mouse (2)
Tag:	His (3)
Source:	HEK293 (1) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	*TGM2/Transglutaminase 2* Protein, Mouse (His)** Heart G alpha(h); TGM2; tTG; tTgase; transglutaminase C; TG(C); TGC; TGase C; transglutaminase H; TGase II; transglutaminase-2; TG2; G-ALPHA-h; GNAH; HEL-S-45; C polypeptide; TGase-2; TGase-H; TGCGNAH	Mouse	E. coli
	TGM2/Transglutaminase 2 protein, a calcium-dependent acyltransferase, catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, leading to the cross-linking or amination of proteins. Involved in diverse biological processes such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification, and apoptosis, TGM2 acts as a protein-glutamine gamma-glutamyltransferase. It mediates the cross-linking of proteins, including ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1, and WDR54. The protein cross-linking activity is inhibited under physiological conditions by GTP, and this inhibition is relieved by Ca(2+) in response to various stresses. In addition to its role in apoptosis by promoting cytoskeletal protein cross-linking and mediating the formation of extracellular matrix scaffolds, TGM2 can use monoamine substrates to catalyze diverse protein post-translational modifications. It plays a crucial role in chromatin organization by mediating serotonylation and dopaminylation of histone H3, contributing to neurotransmission-independent functions in ventral tegmental area (VTA) neurons. Furthermore, TGM2 acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity, highlighting its involvement in signaling pathways beyond its acyltransferase activity. TGM2/Transglutaminase 2 Protein, Mouse (His) is the recombinant mouse-derived TGM2/Transglutaminase 2 protein, expressed by E. coli , with N-His labeled tag. The total length of TGM2/Transglutaminase 2 Protein, Mouse (His) is 685 a.a., with molecular weight of ~78.2 kDa.

	*TGM2/Transglutaminase 2* Protein, Mouse (HEK293, His)** Protein-glutamine gamma-glutamyltransferase 2; Tgm2; Tissue transglutaminase; transglutaminase C; TGase-2	Mouse	HEK293
	The TGM2/transglutaminase 2 protein is a calcium-dependent acyltransferase involved in bone development, angiogenesis, wound healing, and apoptosis. TGM2 is also involved in neurotransmission-independent actions and serves as a signal transducer in α-1 adrenergic receptor-mediated pathways. TGM2/Transglutaminase 2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TGM2/Transglutaminase 2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TGM2/Transglutaminase 2 Protein, Mouse (HEK293, His) is 685 a.a., with molecular weight of 70-90 kDa.

	*TGM2/Transglutaminase 2* Protein, Human (sf9, His, solution)** Protein-glutamine gamma-glutamyltransferase 2; transglutaminase C; TGase-2	Human	Sf9 insect cells

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	Transglutaminase 2 Antibody (YA2255) TGM2; Protein-glutamine gamma-glutamyltransferase 2; Tissue transglutaminase; transglutaminase C; TG(C); TGC; TGase C; transglutaminase H; TGase H; transglutaminase-2; TGase-2	WB, IHC-P, IP	Human, Mouse, Rat
	Transglutaminase 2 Antibody (YA2255) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2255), targeting Transglutaminase 2, with a predicted molecular weight of 77 kDa (observed band size: 77 kDa). Transglutaminase 2 Antibody (YA2255) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

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