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transglutaminase-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Glutaminase (11) Integrin (1) PROTACs (1)
By Research Areas:	Cancer (7) Inflammation/Immunology (4) Metabolic Disease (1)

12

Inhibitors & Agonists

1

Peptides

1

Inhibitory Antibodies

4

Recombinant Proteins

1

Antibodies

Targets Recommended: Transglutaminase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

TG-2-IN-1 1 Publications Verification	Glutaminase	Others
TG-2-IN-1 (Compound D003) is a *transglutaminase-2* (TGM-2) inhibitor. TG-2-IN-1 can be used for the research of myopia .

GK921 4 Publications Verification	Glutaminase	Cancer
GK921 is a transglutaminase 2 (TGase) inhibitor with an IC₅₀ of 7.71 μM for human recombinant TGase 2.

KCC009	Glutaminase	Cancer
KCC009, a *transglutaminase 2* (TG2) inhibitor, induces p53-independent radiosensitization ^[2].

Zampilimab UCB-7858	Glutaminase	Inflammation/Immunology
Zampilimab (UCB-7858) is a monoclonal antibody against *transglutaminase 2* (TG2). Zampilimab has potential application in renal transplant ^[2].

TG-2-IN-4	Glutaminase	Inflammation/Immunology
TG-2-IN-4 (compound 8) is a **transglutaminase 2 (TG2) inhibitor with an IC₅₀** <0.5 mM. TG-2-IN-4 can be used for the research of inflammatory disorder .

NTU281	Glutaminase Apoptosis	Metabolic Disease Inflammation/Immunology
NTU281 is a potent *transglutaminase-2* inhibitor. NTU281 can reduce the increases in serum creatinine and albuminuria in diabetic rats. NTU281 can also reduce glomerular collagen I accumulation, Hic-5 and α-SMA expression, and apoptosis. NTU281 can be used for researching glomerulosclerosis caused by diabetes ^[2].

AA10	Glutaminase	Cancer
AA10 is a potent and irreversible transglutaminase 2 (TG2) inhibitor for cancer research .

LM11	Glutaminase	Cancer
LM11 is an inhibitor of transglutaminase 2 (TG2) with an activity of killing glioblastoma cells by maintaining TG2 in a cytotoxic conformational state .

AA9	Glutaminase	Cancer
AA9 is a potent **Transglutaminase 2 (TG2) inhibitor. AA9 strongly impacts HIF**-mediated hypoxia in MDA-MB-231 cells .

HB-3-20	Integrin	Cancer
HB-3-20 leads to degradation of the cell surface integrin α_Vβ₅. Transglutaminase 2 (TG2) has specificity for HB-3-20 (k_cat/K_M=0.16 μM ^-1min ^-1) .

ZED-1227	Glutaminase	Inflammation/Immunology
ZED-1227 is a specific and orally active **transglutaminase 2 (TG2) inhibitor, with an IC₅₀** of 45 nM. ZED-1227 can block inflammation-induced TG2 expression and activity. ZED-1227 can be used for the research of celiac disease (CeD) ^[2].

PROTAC TG2 degrader-2	PROTACs Glutaminase	Cancer
PROTAC TG2 degrader-2 (compound 7) is a selective, competitive degrader targeting *Transglutaminase 2* (TG2), with K_d > 100 μM. PROTAC TG2 degrader-2 inhibits the cell migration and decreases the level of TG2 in ovarian cancer cells. PROTAC TG2 degrader-2 can be used for ovarian cancer study .

Cat. No.	Product Name	Target	Research Area

HB-3-20	Integrin	Cancer
HB-3-20 leads to degradation of the cell surface integrin α_Vβ₅. Transglutaminase 2 (TG2) has specificity for HB-3-20 (k_cat/K_M=0.16 μM ^-1min ^-1) .

Cat. No.	Product Name	Target	Research Area

Zampilimab UCB-7858	Glutaminase	Inflammation/Immunology
Zampilimab (UCB-7858) is a monoclonal antibody against *transglutaminase 2* (TG2). Zampilimab has potential application in renal transplant ^[2].

Species:	Human (1) Mouse (3)
Tag:	His (4)
Source:	HEK293 (2) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	*TGM2/Transglutaminase 2* Protein, Mouse (His)** Heart G alpha(h); TGM2; tTG; tTgase; transglutaminase C; TG(C); TGC; TGase C; transglutaminase H; TGase II; transglutaminase-2; TG2; G-ALPHA-h; GNAH; HEL-S-45; C polypeptide; TGase-2; TGase-H; TGCGNAH	Mouse	E. coli
	The TGM2/transglutaminase 2 protein is a calcium-dependent acyltransferase involved in bone development, angiogenesis, wound healing, and apoptosis.TGM2 is also involved in neurotransmission-independent actions and serves as a signal transducer in α-1 adrenergic receptor-mediated pathways.TGM2/Transglutaminase 2 Protein, Mouse (His) is the recombinant mouse-derived TGM2/Transglutaminase 2 protein, expressed by E.coli , with N-His labeled tag.

	*TGM2/Transglutaminase 2* Protein, Human (sf9, His, solution)** Protein-glutamine gamma-glutamyltransferase 2; transglutaminase C; TGase-2	Human	Sf9 insect cells
	In summary, TGM2 is a multifunctional enzyme that plays crucial roles in various cellular processes. It acts as a protein-glutamine gamma-glutamyl transferase, mediating the cross-linking of proteins involved in cellular functions. TGM2/Transglutaminase 2 Protein, Human (sf9, His, solution) is the recombinant human-derived TGM2/Transglutaminase 2, expressed by Sf9 insect cells , with N-His labeled tag. ,

	*TGM2/Transglutaminase 2* Protein, Mouse (HEK293, C-His)** Protein-glutamine gamma-glutamyltransferase 2; Tgm2; Tissue transglutaminase; transglutaminase C; TGase-2	Mouse	HEK293
	The TGM2/transglutaminase 2 protein is a calcium-dependent acyltransferase involved in bone development, angiogenesis, wound healing, and apoptosis.TGM2 is also involved in neurotransmission-independent actions and serves as a signal transducer in α-1 adrenergic receptor-mediated pathways.TGM2/Transglutaminase 2 Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived TGM2/Transglutaminase 2 protein, expressed by HEK293 , with C-10*His labeled tag.

	*TGM2/Transglutaminase 2* Protein, Mouse (HEK293, His)** Protein-glutamine gamma-glutamyltransferase 2; Tgm2; Tissue transglutaminase; transglutaminase C; TGase-2	Mouse	HEK293
	The TGM2/transglutaminase 2 protein is a calcium-dependent acyltransferase involved in bone development, angiogenesis, wound healing, and apoptosis.TGM2 is also involved in neurotransmission-independent actions and serves as a signal transducer in α-1 adrenergic receptor-mediated pathways.TGM2/Transglutaminase 2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TGM2/Transglutaminase 2 protein, expressed by HEK293 , with C-6*His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

	Transglutaminase 2 Antibody (YA2255) TGM2; Protein-glutamine gamma-glutamyltransferase 2; Tissue transglutaminase; transglutaminase C; TG(C); TGC; TGase C; transglutaminase H; TGase H; transglutaminase-2; TGase-2	WB, IHC-P, IP	Human, Mouse, Rat
	Transglutaminase 2 Antibody (YA2255) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2255), targeting Transglutaminase 2, with a predicted molecular weight of 77 kDa (observed band size: 77 kDa). Transglutaminase 2 Antibody (YA2255) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

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