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Isoforms Recommended:	Trypanosoma

Results for "

trypanosoma

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Apoptosis (4) Aurora Kinase (1) Autophagy (5) Bacterial (4) Cathepsin (1) COX (2) Cytochrome P450 (4) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (3) EGFR (1) Endogenous Metabolite (3) Fungal (4) HBV (1) Influenza Virus (2) Isotope-Labeled Compounds (2) Lactate Dehydrogenase (3) Necroptosis (2) NTPDase (1) Paraptosis (1) Parasite (80) Phosphodiesterase (PDE) (2) Phospholipase (2) PKA (1) Proteasome (1) Reactive Oxygen Species (2) STAT (3)
By Research Areas:	Cancer (11) Infection (81) Inflammation/Immunology (11) Neurological Disease (1)

By Targets:

Antibiotic (2)

Apoptosis (4)

Aurora Kinase (1)

Autophagy (5)

Bacterial (4)

Cathepsin (1)

COX (2)

Cytochrome P450 (4)

Dihydrofolate reductase (DHFR) (1)

DNA/RNA Synthesis (3)

EGFR (1)

Endogenous Metabolite (3)

Fungal (4)

HBV (1)

Influenza Virus (2)

Isotope-Labeled Compounds (2)

Lactate Dehydrogenase (3)

Necroptosis (2)

NTPDase (1)

Paraptosis (1)

Parasite (80)

Phosphodiesterase (PDE) (2)

Phospholipase (2)

PKA (1)

Proteasome (1)

Reactive Oxygen Species (2)

STAT (3)

By Research Areas:

Cancer (11)

Infection (81)

Inflammation/Immunology (11)

Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147765

*Anti-Trypanosoma* cruzi agent-3**	Parasite	Infection
Anti-Trypanosoma cruzi agent-3 (Compound 7c) is an antiprotozoal agent .

HY-115972

*Anti-Trypanosoma* cruzi agent-2**	Parasite	Infection Inflammation/Immunology
Anti-Trypanosoma cruzi agent-1 (Compd 3b), selective compound against NINOA trypomastigote (IC₅₀ = 0.51 µM) and INC-5 epimastigote form (IC₅₀ = 3.06 µM), posseses anti-T. gondii activity .

HY-148323

*Anti-Trypanosoma* cruzi agent-4**	Parasite	Infection
Anti-Trypanosoma cruzi agent-4 (compound 5c) is an inhibitor of Trypanosoma cruzi. Anti-Trypanosoma cruzi agent-4 can be used for the research of infection .

HY-116004

*Anti-Trypanosoma* cruzi agent-5**	Parasite	Infection
Anti-Trypanosoma cruzi agent-5 (compoung 8) is a potent inhibitor of Trypanosoma cruzi proliferation .

HY-115971

*Anti-Trypanosoma* cruzi agent-1**	Parasite	Infection Inflammation/Immunology
Anti-Trypanosoma cruzi agent-1 (Compd E5) posseses anti-T. gondii activity .

HY-130752

VNI	Cytochrome P450 Parasite	Infection
VNI is an effective inhibitor of CYP51. VNI can inhibit sterol synthesis in Trypanosoma cruzi, exhibiting anti-Trypanosoma cruzi activity .

HY-143322

CRK12-IN-2	Parasite	Infection
CRK12-IN-2 (compound 2) is an inhibitor of CRK12. CRK12-IN-2 shows potency against Trypanosoma congolense and Trypanosoma vivax with EC₅₀ values of 3.2 and 0.08 nM. CRK12-IN-2 can be used for the research of animal trypanosomiasis .

HY-107034

Moxipraquine 349C59	Parasite	Infection
Moxipraquine is a potent insecticide against Trypanosoma cruzi. Moxipraquine effectively inhibits Leishmania major, L. mexicana mexicana and L. brasiliensis panamensis but not L.b. brasiliensis .

HY-128170

Ebsulfur	Parasite	Infection
Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase (TryR) of Trypanosoma brucei, with IC₅₀ values of 61-293 nM for Trypanosoma brucei. Ebsulfur can be used for the research of African trypanosomiasis .

HY-136200

Antitrypanosomal agent 2	Parasite	Infection
Antitrypanosomal agent 2 is a potent and selective *trypanosoma* *brucei* inhibitor .

HY-151943

Antitrypanosomal agent 11	Parasite	Infection
Antitrypanosomal agent 11 is an antitrypanosomal agent that inhibits Trypanosoma cruzi with an IC₅₀ of 0.23 μM .

HY-125632

Ro 19-9638	Parasite	Infection
Ro 19-9638 is the major metabolite of Ro 15-0216. Ro 19-9638 exhibits antiparasitic efficacy against Trypanosoma brucei rhodesiense with an IC₅₀ of 0.0341 µg/mL .

HY-151942

Antitrypanosomal agent 10	Parasite	Infection
Antitrypanosomal agent 10 is an antitrypanosomal agent that inhibits Trypanosoma cruzi with an IC₅₀ of 0.28 μM .

HY-N2656

5,7,8-Trimethoxycoumarin	Parasite	Infection
5,7,8-Trimethoxycoumarin is an anti-parasite agent with IC₅₀s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively .

HY-161299

LAPTc-IN-1	Parasite	Infection
LAPTc-IN-1 (compound 4) is a competitive inhibitor targeting acidic M17 leucinopeptidase (LAPTc) with K_i=0.27 μM. LAPTc-IN-1 is a potential antagonist of the parasite Trypanosoma cruzi .

HY-N0914

Ajugol 2 Publications Verification	Parasite	Others
Ajugol is an iridoid glycoside that can be isolated from Leonurus artemisia. Ajugol has anti-protozoal activity againt Trypanosoma b. rhodesiense with an IC₅₀ of 31.8 μg/mL .

HY-N0914R

Ajugol (Standard)	Parasite	Others
Ajugol (Standard) is the analytical standard of Ajugol. This product is intended for research and analytical applications. Ajugol is an iridoid glycoside that can be isolated from Leonurus artemisia. Ajugol has anti-protozoal activity againt Trypanosoma b. rhodesiense with an IC₅₀ of 31.8 μg/mL .

HY-162656

DHFR-IN-19	Dihydrofolate reductase (DHFR)	Infection
DHFR-IN-19 (Compound 2g) is a selective inhibitor for TbDHFR with K_i of 9 nM. DHFR-IN-19 exhibits antiparasitic activity against Trypanosoma brucei with an EC₅₀ of 14.5 μM .

HY-129228

Lychnopholide	Parasite	Infection
Lychnopholide is a sesquiterpene lactone derived from the Asteraceae, Lychnopholide exhibits anti-trypanosomal activity against Trypanosoma cruzi. lychnopholide encapsulated in nanocapsules reduces its toxicity to mammalian cells. Lychnopholide ameliorates Chagas disease in mouse models .

HY-155655

JC-229	Parasite	Infection
JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT) .

HY-147933

Antitrypanosomal agent 8	Parasite	Infection
Antitrypanosomal agent 8 (compound 3b) has potent antitrypanosomal activity against Trypanosoma brucei with an IC₅₀ value of 0.79 μM and exhibits certain cytotoxicity in L6 cells (IC₅₀=80.95 μM) .

HY-147940

TbPTR1 inhibitor 1	Parasite	Infection
TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC₅₀<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC₅₀=0.66 μM) .

HY-103056

DDD85646 IMP-366	DNA/RNA Synthesis Parasite	Infection
DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC₅₀=2 nM; hNMT IC₅₀=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis .

HY-103033

T.cruzi-IN-1	Parasite	Infection
T.cruzi-IN-1 is a potent Trypanosoma cruzi inhibitor with an IC₅₀ of 8 nM. T.cruzi-IN-1, a 4-trifluoromethyl substituted analog, has the potential for both the acute and chronic stages of Chagas disease .

HY-N10441

3β-Hydroxy-hop-22(29)-ene	Parasite	Infection
3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent. 3β-Hydroxy-hop-22(29)-ene shows moderate activity against Trypanosoma cruzi and Leishmania mexicana .

HY-159097

T.cruzi-IN-4	Parasite	Infection
T.cruzi-IN-4 (Compound 21) is an anti-parasitic agent. T.cruzi-IN-4 inhibits the trypomastigote and amastigote form of Trypanosoma cruzi with IC₅₀ of 0.033 μM (120 h), T.cruzi-IN-4 inhibits the promastigote and amastigote form of Leishmania infantum with IC₅₀ of 28.74 and 61.82 μM. T.cruzi-IN-4 inhibits Leishmania amazonensis promastigote form with IC₅₀ of 18.38 μM .

HY-136637

NPD-001	Phosphodiesterase (PDE) Parasite	Infection
NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC₅₀ values of 4 and 3 nM, respectively. NPD-001 also inhibits human PDEs (phosphodiesterases). NPD-001 shows good anti trypanosomal activity, with an IC₅₀ of 80 nM .

HY-16121

CAA-0225	Cathepsin	Others
CAA-0225 is a tissue protease L inhibitor that inhibits rat liver tissue protease L with a IC₅₀ value of 1.9 nM. CAA-0225 can participate in the degradation of autophagosome membrane markers LC3-II and GABARAP (HY-P72639), improve cardiac function in mice with reperfusion injury, and kill and eliminate Trypanosoma brucei parasites ^[1][2][3].

HY-124112

PAM 1392	Parasite	Infection
PAM 1392 is active orally against *Plasmodium berghei* in mice, *P. cynofologi* and *P. knowlesi* in monkeys and Trypanosoma cruzi in tissue cultures of mice, and *hemolytic streptococci* in vitro. PAM 1392 has antimalarial and antitrypanosomal activities, which is proming for rasearch of drug-resistant malaria .

HY-124623

DNDI-8219	Parasite	Infection
DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.

HY-157028

Antiparasitic agent-19	Others	Infection
Antiparasitic agent-19 (compound 40) is a compound with broad-spectrum antiparasitic activity. Antiparasitic agent-19 has minimal toxicity against Trypanosoma brucei, Leishmania Infantum, and Trypanosoma cruzi .

HY-N2970

Burchellin	Parasite	Infection
Burchellin is a neolignan that can inhibit Trypanosoma cruzi .

HY-155207

Antileishmanial agent-23	Parasite	Infection
Antileishmanial agent-23 (compound G1/9) is a potent and selective trypanothione reductase (TR) inhibitor, with an IC₅₀ of 2.24 ± 0.52 μM. Antileishmanial agent-23 inhibits the growth of Leishmania, Trypanosoma cruzi, and Trypanosoma brucei .

HY-121187

BiPNQ	Parasite	Infection
BiPNQ is a potent inhibitor of Trypanosoma cruzi, the causative agent of Chagas disease .

HY-119938

Tuberculosis inhibitor 1	Bacterial	Infection
Tuberculosis inhibitor 1 is a potent and non-cytotoxic trypanosoma brucei growth inhibitor with an EC₅₀ of 5 nM .

HY-N3247

Monomethyl kolavate	Parasite	Others
Monomethyl kolavate is a Trypanosoma brucei GAPDH enzyme (TbGAPDH) inhibitor with theIC₅₀ value of 2 µM .

HY-145287

S-MGB-234	DNA/RNA Synthesis Parasite	Infection
S-MGB-234 is a minor groove binder of Animal African Trypanosomiasis (AAT). S-MGB-234 displays excellent in vitro activities against the principal causative organisms of AAT; Trypanosoma congolense, and Trypanosoma vivax. S-MGB-234 does not show cross-resistance with the current diamidine agents and are not internalized via the transporters used by diamidines .

HY-113907

SDZ-285604 VNF	Cytochrome P450 Parasite	Infection
SDZ-285604 (VNF) is a T. cruzi CYP51 inhibitor and can be used for study of Trypanosoma cruzi infection .

HY-145287A

S-MGB-234 TFA	DNA/RNA Synthesis Parasite	Infection
S-MGB-234 TFA is a minor groove binder used for African Animal Trypanosomiasis (AAT). S-MGB-234 exhibits excellent in vitro activity against the primary pathogens of AAT: Trypanosoma congolense and Trypanosoma vivax. S-MGB-234 TFA does not show cross-resistance with current diamidine active molecules and is not internalized via the transporters used by diamidines .

HY-108938

SDZ285428	Cytochrome P450 Fungal Parasite	Infection
SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h) .

HY-118580

RO-09-4609	Fungal Parasite	Infection
RO-09-4609 exhibits antimicrobial activity, that inhibits Candida albicans, Trypanosoma brucei and Plasmodium vivax through inhibition of N-myristoyl transferase .

HY-125731

Glycodeoxycholic Acid	Endogenous Metabolite STAT Autophagy	Inflammation/Immunology Cancer
Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

HY-146049

Antitrypanosomal agent 4	Parasite	Infection
Antitrypanosomal agent 4 (compound 19) is a potent and blood-brain barrier permeable antitrypanosomal agent. Antitrypanosomal agent 4 has good activity against Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei brucei (T. b. brucei) with IC₅₀s of 1.2 μM and 70 nM, respectively . Antitrypanosomal agent 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W040073

Nifurtimox	Parasite Lactate Dehydrogenase	Infection Cancer
Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).

HY-N7266

Obtusifoliol	Cytochrome P450 Parasite	Infection Cancer
Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with K_d values of 1.2 μM and 1.4 μM for Trypanosoma brucei (TB) and human CYP51, respectively .

HY-101015A

OBAA	Phospholipase Apoptosis	Inflammation/Immunology
OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC₅₀ of 70 nM. OBAA blocks Melittin-induced Ca ²⁺ influx in Trypanosoma brucei with an IC₅₀ of 0.4 μM .

HY-144296

Purine phosphoribosyltransferase-IN-2	Parasite	Infection
Purine phosphoribosyltransferase-IN-2 is a potent inhibitor of the Plasmodium falciparum ((Pf)), Plasmodium vivax ((Pv)) and Trypanosoma brucei ((Tbr)) 6-oxopurine phosphoribosyltransferase (PRT), with K_is of 30, 20 and 2 nM, respectively .

HY-117129

MK 436 MK-0436	Parasite	Infection
MK 436 (MK-0436) is a metabolite with anti-trypanosomal activity that can be isolated from dog urine, particularly effective against Trypanosoma cruzi, the pathogen responsible for Chagas disease in South America .

HY-129130

Canthin-6-one N-oxide Canthin-6-one 3-oxide	Parasite	Infection
Canthin-6-one N-oxide (Canthin-6-one 3-oxide) is an orally active antiparasitic agent with limited activity .

HY-W040073S

Nifurtimox-d4	Isotope-Labeled Compounds Parasite Lactate Dehydrogenase	Infection Cancer
Nifurtimox-d₄ is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0914

Ajugol 2 Publications Verification	Structural Classification Iridoids Classification of Application Fields Terpenoids Labiatae Source classification Other Diseases Scrophulariaceae Lactuca perennis Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Disease Research Fields	Parasite
Ajugol is an iridoid glycoside that can be isolated from Leonurus artemisia. Ajugol has anti-protozoal activity againt Trypanosoma b. rhodesiense with an IC₅₀ of 31.8 μg/mL .

HY-125731

Glycodeoxycholic Acid	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite STAT Autophagy
Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

HY-N7266

Obtusifoliol	Infection Structural Classification Natural Products Human Gut Microbiota Metabolites Sorghum bicolor (Linn.) Moench Microorganisms Classification of Application Fields Gramineae Source classification Plants Endogenous metabolite Disease Research Fields	Cytochrome P450 Parasite
Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with K_d values of 1.2 μM and 1.4 μM for Trypanosoma brucei (TB) and human CYP51, respectively .

HY-N2656

5,7,8-Trimethoxycoumarin	Zanthoxylum dimorphophyllum Hemsl. Structural Classification Rutaceae Coumarins Phenylpropanoids Plants	Parasite
5,7,8-Trimethoxycoumarin is an anti-parasite agent with IC₅₀s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively .

HY-N0914R

Ajugol (Standard)	Structural Classification Iridoids Terpenoids Labiatae Source classification Scrophulariaceae Lactuca perennis Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey	Parasite
Ajugol (Standard) is the analytical standard of Ajugol. This product is intended for research and analytical applications. Ajugol is an iridoid glycoside that can be isolated from Leonurus artemisia. Ajugol has anti-protozoal activity againt Trypanosoma b. rhodesiense with an IC₅₀ of 31.8 μg/mL .

HY-129228

Lychnopholide	Lychnophora pseudovillosissima Semir & Leitão Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae	Parasite
Lychnopholide is a sesquiterpene lactone derived from the Asteraceae, Lychnopholide exhibits anti-trypanosomal activity against Trypanosoma cruzi. lychnopholide encapsulated in nanocapsules reduces its toxicity to mammalian cells. Lychnopholide ameliorates Chagas disease in mouse models .

HY-N10441

3β-Hydroxy-hop-22(29)-ene	Cnidoscolus spinosus Lundell Triterpenes Terpenoids Source classification Euphorbiaceae Plants	Parasite
3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent. 3β-Hydroxy-hop-22(29)-ene shows moderate activity against Trypanosoma cruzi and Leishmania mexicana .

HY-N2970

Burchellin	Structural Classification Source classification Lignans Piperaceae Phenylpropanoids Plants Piper kadsura (Choisy) Ohwi	Parasite
Burchellin is a neolignan that can inhibit Trypanosoma cruzi .

HY-N3247

Monomethyl kolavate	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Inula grandis Schrenk ex Fish..	Parasite
Monomethyl kolavate is a Trypanosoma brucei GAPDH enzyme (TbGAPDH) inhibitor with theIC₅₀ value of 2 µM .

HY-129130

Canthin-6-one N-oxide Canthin-6-one 3-oxide	Structural Classification Alkaloids Simaroubaceae Other Alkaloids Source classification Eurycoma harmandiana Pierre Plants	Parasite
Canthin-6-one N-oxide (Canthin-6-one 3-oxide) is an orally active antiparasitic agent with limited activity .

HY-N4033

Horminone 7α-Hydroxyroyleanone	Quinones Structural Classification Verbenaceae Source classification Verbena officinalis Linn. Plants Phenanthrenequinones	Bacterial
Horminone is an abietan diterpene quinone that can be isolated from Labiatae family. Horminone increases of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum levels in vivo. Horminone inhibits the growth of Trypanosoma cruzi and shows antibacterial activity .

HY-N9179

3′,4′,5′,5,6,7-Hexamethoxyflavone	Infection Flavonoids Classification of Application Fields Flavones Source classification Lupinus perennis L. Plants Compositae Disease Research Fields	Parasite
3′,4′,5′,5,6,7-Hexamethoxyflavone is a flavonoid with antiprotozoal activity. 3′,4′,5′,5,6,7-Hexamethoxyflavone inhibits trypanosoma bruceirhodesiense with IC₅₀ of 21.3 μM (8.58 g/mL) .

HY-125731R

Glycodeoxycholic Acid (Standard)	Structural Classification Microorganisms Source classification Endogenous metabolite Steroids	Endogenous Metabolite STAT Autophagy
Glycodeoxycholic Acid (Standard) is the analytical standard of Glycodeoxycholic Acid. This product is intended for research and analytical applications. Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

HY-N10547

6-O-Methylcatalpol	Structural Classification Scrophularia ningpoensis Hemsl. Polymer products Scrophulariaceae Plants Saccharides Monosaccharides	Parasite
6-O-Methylcatalpol can be isolated from the roots of Scrophularia ningpoensis. 6-O-Methylcatalpol has anti-protozoal activity against Trypanosoma b. rhodesiense and Leishmania donovani (IC₅₀: 32.5 and 8.3 μg/mL) .

HY-W020182

α-Terpinene Terpilene	Infection Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Biological Pesticide Research Agricultural Research	Fungal Parasite
α-Terpinene (Terpilene) is a monoterpene found in the essential oils of a large variety of foods and aromatic plants such as Mentha piperita. α-Terpinene is active against Trypanosoma evansi and has the potential for trypanosomosis treatment. α-Terpinene has antioxidant and antifungal properties .

HY-122267

Clovamide trans-Clovamide	Alkaloids Structural Classification other families Other Alkaloids Source classification Phenols Polyphenols Plants	Reactive Oxygen Species Bacterial Influenza Virus Apoptosis
Clovamide (trans-Clovamide), a natural phenolic compound, is a potent antioxidant. Clovamide is an excellent ROS and oxygen radical scavenger. Clovamide also has anti-inflammatory and neuroprotective effects . Clovamide is an anti-microbial with activity against the human pathogens influenza A subtype H5N1, Trypanosoma evansi, and *Heliobacter pylori* .

HY-N1716

2′′-Acetylastragalin	Structural Classification Flavonoids Flavones Ranunculaceae Source classification Plants Delphinium staphisagria L.	Parasite
2’’-Acetylastragalin (Compound 2) is a compound isolated from the aerial parts of Delphinium staphisagria, with an IC₅₀ value of 6.5 μM for Vero cells. 2’’-Acetylastragalin has trypanoidal activity .

HY-N10443

Mammea A/BA	other families Source classification Coumarins Phenylpropanoids Plants Calophyllum brasiliense auct. non Camb.	Parasite Apoptosis Autophagy Reactive Oxygen Species
Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, reactive oxygen species (ROS) production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea A/BA can be used for researching chagas disease .

HY-N12788

T-Cadinol	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Casearia sylvestris Sw. Salicaceae	Parasite
T-Cadinol is a sesquiterpene isolated from C. sylvestris that exhibits anti-Trypanosoma cruzi activity, with IC₅₀ values of 18.2 μM and 15.8 μM against trypomastigote and amastigote forms, respectively. T-Cadinol can induce mitochondrial damage in parasites, leading to membrane hyperpolarization and decreased levels of reactive oxygen species. T-Cadinol can be used for the research of Chagas disease .

HY-N0389

Columbin 1 Publications Verification	Structural Classification other families Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Inflammation/Immunology Disease Research Fields	COX Parasite
Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC₅₀=53.1 μM) over COX-1 (EC₅₀=327 μM) .

HY-N0389R

Columbin (Standard)	Structural Classification other families Terpenoids Source classification Diterpenoids Plants	COX Parasite
Columbin (Standard) is the analytical standard of Columbin. This product is intended for research and analytical applications. Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM) .

HY-W020182R

α-Terpinene (Standard)	Structural Classification Natural Products other families Source classification Plants	Fungal Parasite
α-Terpinene (Standard) is the analytical standard of α-Terpinene. This product is intended for research and analytical applications. α-Terpinene (Terpilene) is a monoterpene found in the essential oils of a large variety of foods and aromatic plants such as Mentha piperita. α-Terpinene is active against Trypanosoma evansi and has the potential for trypanosomosis treatment. α-Terpinene has antioxidant and antifungal properties .

HY-126417

Methylenetanshinquinone	Structural Classification Natural Products Leguminosae Labiatae Source classification Samanea saman (Jacq.) Merr. Plants	Parasite
Methylenetanshinquinone is a natural compound with antiplasmodial, antitrypanosomal and antioxidative activities. Methylenetanshinquinone can be used for the research of parasite infection .

Cat. No.	Product Name	Chemical Structure

HY-W040073S

Nifurtimox-d4
Nifurtimox-d₄ is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).

HY-W653999

Glycodeoxycholic acid-d5
Glycodeoxycholic acid-d₅ is deuterium labeled Glycodeoxycholic Acid. Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

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