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Results for "

tryptophan hydroxylase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Tryptophan Hydroxylase (18) 5-HT Receptor (4)
By Research Areas:	Cancer (6) Cardiovascular Disease (4) Inflammation/Immunology (1) Metabolic Disease (3) Neurological Disease (11)
Click Chemistry:	Alkynes (2)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Click Chemistry

Targets Recommended: Tryptophan Hydroxylase Dopamine β-hydroxylase HIF/HIF Prolyl-Hydroxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W092533

6-Fluorotryptophan	Tryptophan Hydroxylase	Neurological Disease
6-Fluorotryptophan, a competitive inhibitor of **tryptophan hydroxylase**, produced a transient disruption of sleep in rats chronically implanted with EEG recording electrodes .

HY-23460

p-Ethynylphenylalanine 1 Publications Verification 4-Ethynyl-L-phenylalanine	Tryptophan Hydroxylase	Neurological Disease
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a K_i of 32.6 μM . p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-23460A

p-Ethynylphenylalanine hydrochloride 1 Publications Verification 4-Ethynyl-L-phenylalanine hydrochloride	Tryptophan Hydroxylase	Neurological Disease
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a K_i of 32.6 μM . p-Ethynylphenylalanine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-13041

LX-1031 1 Publications Verification	Tryptophan Hydroxylase	Neurological Disease
LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally.

HY-15849

LP-533401 3 Publications Verification	Tryptophan Hydroxylase	Cardiovascular Disease Metabolic Disease
LP-533401 is a Tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut.

HY-15849A

LP-533401 hydrochloride 3 Publications Verification	Tryptophan Hydroxylase	Cardiovascular Disease Metabolic Disease
LP-533401 hydrochloride is a tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut.

HY-13055A

Telotristat ethyl 1 Publications Verification LX1032; LX1606	Tryptophan Hydroxylase	Neurological Disease Cancer
Telotristat ethyl (LX1032) is a novel, orally-delivered inhibitor of **tryptophan hydroxylase** that reduces serotonin production.

HY-13055B

Telotristat LP-778902	Tryptophan Hydroxylase	Neurological Disease Cancer
Telotristat (LP-778902) is a potent **tryptophan hydroxylase** inhibitor with an in vivo IC₅₀ of 0.028 μM.

HY-13055

Telotristat etiprate 1 Publications Verification LX1606 Hippurate	Tryptophan Hydroxylase	Neurological Disease Cancer
Telotristat etiprate (LX1606 Hippurate) is a novel, orally-delivered inhibitor of **tryptophan hydroxylase** that reduces serotonin production.

HY-19572

ACT-678689	Tryptophan Hydroxylase	Inflammation/Immunology
ACT-678689 (Compound Example 1.53.4) is a **tryptophan hydroxylase (TPH) inhibitor with an IC₅₀** of 8 nM .

HY-B1368

Fenclonine Maximum Cited Publications 15 Publications Verification 4-Chloro-DL-phenylalanine; PCPA; CP-10188	Tryptophan Hydroxylase	Neurological Disease Cancer
Fenclonine is a selective and irreversible **tryptophan hydroxylase** inhibitor, which is a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine can be used in carcinoid syndrome research .

HY-13055BR

Telotristat (Standard)	Tryptophan Hydroxylase	Neurological Disease Cancer
Telotristat (Standard) is the analytical standard of Telotristat. This product is intended for research and analytical applications. Telotristat (LP-778902) is a potent **tryptophan hydroxylase** inhibitor with an in vivo IC₅₀ of 0.028 μM.

HY-W019599

4-Chloro-L-phenylalanine L-PCPA	5-HT Receptor Tryptophan Hydroxylase	Neurological Disease
4-Chloro-L-phenylalanine (L-PCPA) is a 5-HT biosynthesis inhibitor. 4-Chloro-L-phenylalanine is also a nonspecific antagonist of both isoforms of tryptophan hydroxylase (TPH1 and TPH2) .

HY-120083

Rodatristat KAR5417	5-HT Receptor Tryptophan Hydroxylase	Cardiovascular Disease
Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC₅₀s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice .

HY-101124

Rodatristat ethyl KAR5585	Tryptophan Hydroxylase 5-HT Receptor	Cardiovascular Disease
Rodatristat ethyl (KAR5585) is a first-in-class oral tryptophan hydroxylase 1 (TPH1) Inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH) .

HY-101456

PCPA methyl ester hydrochloride 2 Publications Verification 4-Chloro-DL-phenylalanine methyl ester hydrochloride	Tryptophan Hydroxylase 5-HT Receptor	Neurological Disease
PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride), a reversible **tryptophan hydroxylase inhibitor, is a serotonin (5-HT) synthesis** inhibitor. PCPA methyl ester hydrochloride crosses the blood brain barrier and reduces 5-HT central availability .

HY-156093

TPH1-IN-1	Tryptophan Hydroxylase	Metabolic Disease
TPH1-IN-1 (compound 40) is a xanthine derivative and an inhibitor of tryptophan hydroxylase TPH1 (IC₅₀: 110.1 nM). TPH1-IN-1 has good in vitro activity and liver microsome stability, and effectively inhibits adipocyte differentiation of T3-L1 cells .

HY-157014

TPT-004	Tryptophan Hydroxylase	Cancer
TPT-004 is a TPH inhibitor. TPT-004 has superior pharmacokinetic and pharmacodynamic properties. TPT-004 also has good efficacy in preclinical models of peripheral serotonin attenuation and colorectal tumor growth .

Cat. No.	Product Name	Target	Research Area

HY-W019599

4-Chloro-L-phenylalanine L-PCPA	5-HT Receptor Tryptophan Hydroxylase	Neurological Disease
4-Chloro-L-phenylalanine (L-PCPA) is a 5-HT biosynthesis inhibitor. 4-Chloro-L-phenylalanine is also a nonspecific antagonist of both isoforms of tryptophan hydroxylase (TPH1 and TPH2) .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P73566

	Tryptophan Hydroxylase 1/TPH-1 Protein, Human (His) TPH; TPH-1; TPRH; tryptophan 5-hydroxylase 1; tryptophan hydroxylase 1	Human	E. coli
	The tryptophan hydroxylase 1 (TPH-1) protein is key to serotonin biosynthesis, catalyzing the rate-limiting step: the oxidation of L-tryptophan to 5-hydroxy-L-tryptophan. This enzyme activity is critical for the synthesis of serotonin, a neurotransmitter that affects mood, sleep, and appetite. Tryptophan Hydroxylase 1/TPH-1 Protein, Human (His) is the recombinant human-derived Tryptophan Hydroxylase 1/TPH-1 protein, expressed by E. coli , with N-His labeled tag. The total length of Tryptophan Hydroxylase 1/TPH-1 Protein, Human (His) is 443 a.a., with molecular weight of ~48 kDa.

HY-P71375

	TPH2 Protein, Human (His) tryptophan 5-hydroxylase 2; Neuronal tryptophan hydroxylase; tryptophan 5-Monooxygenase 2; TPH2; NTPH	Human	E. coli
	TPH2 Protein, an isozyme of tryptophan hydroxylase, is a member of the pterin-dependent aromatic acid hydroxylase family. TPH2 is selectively expressed only in the serotonergic neurons of the raphe nuclei and is a rate-limiting enzyme in the brain serotonin synthesis pathway. TPH2 plays a more prominent role in the 5-HT synthesis in the brain. Moreover, it is a key factor in maintaining normal serotonin transfer in the central nervous system. TPH2 Protein, Human (His) is the recombinant human-derived TPH2 protein, expressed by E. coli , with N-6*His labeled tag.

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HY-P83004

	Tryptophan 5 Hydroxylase 1 Antibody (YA2749) TPH1; MGC119994; TPRH; TRPH; tryptophan 5-hydroxylase 1; tryptophan hydroxylase	WB, IHC-P, IP	Human, Mouse, Rat
	Tryptophan 5 Hydroxylase 1 Antibody (YA2749) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2749), targeting Tryptophan 5 Hydroxylase 1, with a predicted molecular weight of 51 kDa (observed band size: 51 kDa). Tryptophan 5 Hydroxylase 1 Antibody (YA2749) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-23460

p-Ethynylphenylalanine 1 Publications Verification 4-Ethynyl-L-phenylalanine		Alkynes
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a K_i of 32.6 μM . p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-23460A

p-Ethynylphenylalanine hydrochloride 1 Publications Verification 4-Ethynyl-L-phenylalanine hydrochloride		Alkynes
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a K_i of 32.6 μM . p-Ethynylphenylalanine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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