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Results for "

tyrosinase and melanogenesis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Tyrosinase (13) AMPK (1) Antibiotic (2) Bacterial (1) Beta-lactamase (1) Endogenous Metabolite (2) ERK (2) Fluorescent Dye (1) Influenza Virus (2) Melanocortin Receptor (2) p38 MAPK (1) PPAR (1) Ras (2) Sirtuin (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (2) Endocrinology (1) Infection (1) Inflammation/Immunology (3) Metabolic Disease (4) Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Targets Recommended: Tyrosinase Fat Mass and Obesity-associated Protein (FTO)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0637A

(±)-Eriodictyol (±)-Huazhongilexone; Dihydroluteolin	Melanocortin Receptor	Metabolic Disease
(±)-Eriodictyol ((±)-Huazhongilexone), a flavonoid, is a potent *melanogenesis* inhibitor with an IC₅₀ of 48 μM. (±)-Eriodictyol suppresses tyrosinase, TRP-1, and TRP-2 mRNA expression. (±)-Eriodictyol has strong anti-plasmin activities .

HY-161846

Tyrosinase-IN-31	Tyrosinase	Neurological Disease
Tyrosinase-IN-31 (compound 2-06) is a central-targeting tyrosinase inhibitor (tyrosinase: monophenolase IC₅₀=70.44 μM, diphenolase IC₅₀=1.89 μM). Tyrosinase-IN-31 can inhibit the tyrosinase and melanogenesis. Tyrosinase-IN-31 can penetrate the BBB and enter the central nervous system (CNS). Tyrosinase-IN-31 shows neuroprotective effects and Parkinsonism behavior improving function .

HY-158021

Tyrosinase-IN-26	Tyrosinase	Cancer
Tyrosinase-IN-26 (compound 13) is a uncompetitive *tyrosinase* inhibitor with the an IC₅₀ value of 68.86 µM. Tyrosinase-IN-26 can suppresses melanogenesis .

HY-161969

Tyrosinase-IN-34	Tyrosinase	Cancer
Tyrosinase-IN-34 (compound 5a) is a human *tyrosinase* inhibitor (IC₅₀: 3.5 μM) with the potential to control melanogenesis and pigmentation .

HY-143459

Tyrosinase-IN-5	Tyrosinase	Cancer
Tyrosinase-IN-5 (compound 16c) is a potent inhibitor of *tyrosinase* with an IC₅₀ of 0.02 μM. Tyrosinase-IN-5 efficiently suppresses the melanogenesis without significant toxicity on cells .

HY-N3425

Kazinol U	AMPK	Others
Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation .

HY-149698

Tyrosinase-IN-17	Tyrosinase	Cancer
Tyrosinase-IN-17 (Compound 5b) is a lipophilic, skin-permeable, and non-cytotoxic *Tyrosinase* inhibitor (pIC₅₀=4.99). Tyrosinase-IN-17 can be used for research on melanin-related diseases, such as melanoma, melanogenesis, etc .

HY-N5118

Chimonanthine (-)-Chimonanthine	Tyrosinase	Cancer
Chimonanthine is an alkaloid of Chimonanthus praecox, inhibits tyrosinase and tyrosine-related protein-1 mRNA expression, amd inhibits melanogenesis .

HY-117761

MHY908	PPAR	Metabolic Disease Cancer
MHY908 is a potent dual agonist of PPARα and PPARγ . MHY908 also inhibits melanogenesis through inhibition of mushroom tyrosinase activity .

HY-P0096

Decapeptide-12	Tyrosinase Sirtuin	Inflammation/Immunology Endocrinology
Decapeptide-12, a small oligopeptide, is a *tyrosinase* inhibitor that interacts with C-terminal residue of tyrosinase (K_d: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC₅₀: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

HY-P4497

Prolylserine	ERK	Cancer
Prolylserine, a dipeptide, is an inhibitor of melanogenesis production in Mel-Ab cells. Prolylserine decreases expression of microphthalmia-associated transcription factor (MITF) and *tyrosinase, induces phorphosylation of ERK, but not cAMP response element binding protein (CREB)* .

HY-134046

(-)-Isodocarpin Isodocarpin	Melanocortin Receptor	Metabolic Disease
(-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent *melanogenesis* inhibitor with an IC₅₀ of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA .

HY-N10016

Chlorogenic acid butyl ester	Tyrosinase	Cancer
Chlorogenic acid butyl ester, a caffeoylquinic acid, is a potent *melanogenesis* inhibitor. Chlorogenic acid butyl ester inhibits the expression of microphtalmia-associated transcription factor (MITF), *tyrosinase, tyrosinerelated protein 1 (TRP-1), and TRP-2*. Chlorogenic acid butyl ester also shows antioxidant activity .

HY-N0113A

Hordenine sulfate Ordenina sulfate; Peyocactine sulfate	Antibiotic	Others
Hordenine sulfate (Ordenina sulfate) is an active compound extracted from malted barley that has melanin-inhibiting activity. Hordenine sulfate significantly reduced melanin content and reduced intracellular cAMP levels. Hordenine sulfate inhibits the expression of proteins related to melanogenesis, including microblind transcription factor (MITF), tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2. Therefore, Hordenine sulfate can be used as an active ingredient to inhibit pigmentation .

HY-126618

Aspochalasin I	Tyrosinase	Cancer
Aspochalasin I exhibits cytotoxicity against cancer cells NCIH460, MCF-7 and SF-268, with IC₅₀s of 22.1, 33.4 and 19.9 μM. Aspochalasin I inhibits melanogenesis (IC₅₀ of 22.4 μM) through inhibition of *tyrosinase*, and can thus be used as whitening agent .

HY-D0168

Orcinol 3,5-Dihydroxytoluene	Fluorescent Dye Tyrosinase p38 MAPK ERK	Metabolic Disease Cancer
Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases .

HY-I0400

N-Acetylneuraminic acid 3 Publications Verification NANA; Lactaminic acid	Tyrosinase Ras Influenza Virus Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Cancer
N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing *tyrosinase* activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia .

HY-I0400R

N-Acetylneuraminic acid (Standard)	Tyrosinase Ras Influenza Virus Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Cancer
N-Acetylneuraminic acid (Standard) is the analytical standard of N-Acetylneuraminic acid. This product is intended for research and analytical applications. N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia .

HY-105284R

Sulopenem (Standard)	Beta-lactamase Bacterial Antibiotic	Infection
N-Acetylneuraminic acid (Standard) is the analytical standard of N-Acetylneuraminic acid. This product is intended for research and analytical applications. N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia .

HY-N3810

ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid	Tyrosinase	Others
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is an anti-melanin synthesis *tyrosinase* inhibitor, which can be isolated from Pteris fern. ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid regulates the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF). The 11α-OH, 15-oxo and 16-en moieties of ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid are key fragments that inhibit melanin synthesis. The 19-COOH moiety has been implicated in the inhibition of cytotoxicity associated with 11α-OH KA and related compounds .

Cat. No.	Product Name	Type

HY-D0168

Orcinol 3,5-Dihydroxytoluene	Dyes
Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases .

Orcinol

3,5-Dihydroxytoluene

Dyes

Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases .

Cat. No.	Product Name	Target	Research Area

HY-P0096

Decapeptide-12	Tyrosinase Sirtuin	Inflammation/Immunology Endocrinology
Decapeptide-12, a small oligopeptide, is a *tyrosinase* inhibitor that interacts with C-terminal residue of tyrosinase (K_d: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC₅₀: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

HY-P4497

Prolylserine	ERK	Cancer
Prolylserine, a dipeptide, is an inhibitor of melanogenesis production in Mel-Ab cells. Prolylserine decreases expression of microphthalmia-associated transcription factor (MITF) and *tyrosinase, induces phorphosylation of ERK, but not cAMP response element binding protein (CREB)* .

(±)-Eriodictyol (±)-Huazhongilexone; Dihydroluteolin	Structural Classification Flavonoids Lythraceae Lawsonia inermis L. Flavones Source classification Plants	Melanocortin Receptor
(±)-Eriodictyol ((±)-Huazhongilexone), a flavonoid, is a potent *melanogenesis* inhibitor with an IC₅₀ of 48 μM. (±)-Eriodictyol suppresses tyrosinase, TRP-1, and TRP-2 mRNA expression. (±)-Eriodictyol has strong anti-plasmin activities .

Orcinol 3,5-Dihydroxytoluene	Structural Classification Microorganisms Classification of Application Fields Source classification Other Diseases Phenols Polyphenols Ericaceae Plants Disease Research Fields	Fluorescent Dye Tyrosinase p38 MAPK ERK
Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases .

N-Acetylneuraminic acid 3 Publications Verification NANA; Lactaminic acid	Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Monosaccharides	Tyrosinase Ras Influenza Virus Endogenous Metabolite
N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing *tyrosinase* activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia .

Kazinol U	Flavonoids other families Classification of Application Fields Flavanols Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	AMPK
Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation .

Chimonanthine (-)-Chimonanthine	Alkaloids Classification of Application Fields Source classification Chimonanthus nitens Oliv. Plants Disease Research Fields Alkaloid Dimers Cancer Calycanthaceae	Tyrosinase
Chimonanthine is an alkaloid of Chimonanthus praecox, inhibits tyrosinase and tyrosine-related protein-1 mRNA expression, amd inhibits melanogenesis .

(-)-Isodocarpin Isodocarpin	Labiatae Source classification Ambrosia camphorata (Greene) W.W.Payne Plants	Melanocortin Receptor
(-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent *melanogenesis* inhibitor with an IC₅₀ of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA .

Chlorogenic acid butyl ester	Structural Classification Lysimachia davurica Ledeb. Source classification Phenols Polyphenols Plants Primulaceae	Tyrosinase
Chlorogenic acid butyl ester, a caffeoylquinic acid, is a potent *melanogenesis* inhibitor. Chlorogenic acid butyl ester inhibits the expression of microphtalmia-associated transcription factor (MITF), *tyrosinase, tyrosinerelated protein 1 (TRP-1), and TRP-2*. Chlorogenic acid butyl ester also shows antioxidant activity .

Hordenine sulfate Ordenina sulfate; Peyocactine sulfate	Structural Classification Monophenols Gramineae Source classification Hordeum vulgare Phenols Plants	Antibiotic
Hordenine sulfate (Ordenina sulfate) is an active compound extracted from malted barley that has melanin-inhibiting activity. Hordenine sulfate significantly reduced melanin content and reduced intracellular cAMP levels. Hordenine sulfate inhibits the expression of proteins related to melanogenesis, including microblind transcription factor (MITF), tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2. Therefore, Hordenine sulfate can be used as an active ingredient to inhibit pigmentation .

Aspochalasin I	Structural Classification Natural Products Source classification Ericameria laricifolia (A.Gray) Shinners Plants Compositae	Tyrosinase
Aspochalasin I exhibits cytotoxicity against cancer cells NCIH460, MCF-7 and SF-268, with IC₅₀s of 22.1, 33.4 and 19.9 μM. Aspochalasin I inhibits melanogenesis (IC₅₀ of 22.4 μM) through inhibition of *tyrosinase*, and can thus be used as whitening agent .

N-Acetylneuraminic acid (Standard)	Structural Classification Microorganisms Source classification Endogenous metabolite Saccharides Monosaccharides	Tyrosinase Ras Influenza Virus Endogenous Metabolite
N-Acetylneuraminic acid (Standard) is the analytical standard of N-Acetylneuraminic acid. This product is intended for research and analytical applications. N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia .

ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid	Structural Classification Terpenoids Source classification Pteridaceae Diterpenoids Plants Pteris semipinnata L. Sp.	Tyrosinase
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is an anti-melanin synthesis *tyrosinase* inhibitor, which can be isolated from Pteris fern. ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid regulates the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF). The 11α-OH, 15-oxo and 16-en moieties of ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid are key fragments that inhibit melanin synthesis. The 19-COOH moiety has been implicated in the inhibition of cytotoxicity associated with 11α-OH KA and related compounds .

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