Search Result

Results for "

voltage-sensitive

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (15) Carbonic Anhydrase (6) Fluorescent Dye (9) GABA Receptor (6) iGluR (6) Isotope-Labeled Compounds (3) Na+/Ca2+ Exchanger (1) Parasite (1) Potassium Channel (7) PROTAC Linkers (1) Sodium Channel (10)
By Research Areas:	Cancer (1) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (1) Neurological Disease (16)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: VDAC VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1512

Oxonol 595	Fluorescent Dye	Others
Oxonol 595 is a voltage-sensitive fluorescent dye .

HY-B0473

Tetracaine hydrochloride Amethocaine hydrochloride	Calcium Channel	Neurological Disease
Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca ²⁺ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic .

HY-D1092

DiBAC4(5)	Fluorescent Dye	Neurological Disease
DiBaC4(5) is a fluorescent voltage-sensitive dye that can be used to monitor the transmembrane potentials when Papain-dissociated retinal cells from adult zebrafish were exposed to GABAergic ligands. DiBaC4(5) is a potential-sensitive fluorescence dye .

HY-101892

DiBAC4(3) Maximum Cited Publications 7 Publications Verification	Fluorescent Dye	Others
DiBAC4(3) is a voltage-sensitive fluorescent dye (λ_ex=490 nm, λ_em=505 nm).

HY-D1439

RH 795	Fluorescent Dye	Others
RH 795 is a fast-response voltage-sensitive dye .

HY-111157

Dezinamide AHR11748; AN051; ADD94057	Sodium Channel	Neurological Disease
Dezinamide (ADD94057) is an antiepileptic agent. Dezinamide binds to the voltage-sensitive sodium channel .

HY-114958

RH 421	Fluorescent Dye	Others
RH 421 is a voltage-sensitive styryl dye that can penetrate through the lipid bilayers. RH 421 is a chromogenic substrate for β-galactosidase .

HY-U00218

McN5691 RWJ26240	Calcium Channel	Cardiovascular Disease
McN5691 is a voltage-sensitive calcium channel blocker.

HY-N12093

Cevadine	Sodium Channel Parasite	Infection
Cevadine is a voltage-sensitive sodium channel agonist. Cevadine has insecticidal activity .

HY-110234

Topiramate D12 McN 4853 D12 ; RWJ 17021 D12	iGluR GABA Receptor Sodium Channel Calcium Channel Potassium Channel Carbonic Anhydrase	Neurological Disease
Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .

HY-D1427

Di-2-ANEPEQ	Fluorescent Dye	Neurological Disease
Di-2-ANEPEQ is a voltage sensitive membrane potential fluorescence dye. Di-2-ANEPEQ can be used for the evaluation of voltage-sensitive fluorescence dyes for monitoring neuronal activity in the embryonic central nervous system .

HY-101891

Di-8-ANEPPS 1 Publications Verification	Fluorescent Dye	Others
Di-8-ANEPPS is a naphthylstyryl voltage-sensitive dye, shifting both their fluorescence excitation and emission spectra upon changes in V_m .

HY-129763

Di-4-ANEPPS	Fluorescent Dye	Others
Di-4-ANEPPS is a voltage-sensitive dye in membrane potential. Di-4-ANEPPS allows reaching a time resolution better than 1 ms and exhibits changes in fluorescence of up to 10% per 100 mV. Di-4-ANEPPS is a common tool for mapping cardiac electrical activity. Di-4-ANEPPS demonstrate significant direct irreversible effect on spontaneous heart rate and ventricular impulse conduction in rabbit isolated heart model .

HY-110234R

Topiramate D12 (Standard)	iGluR GABA Receptor Sodium Channel Calcium Channel Potassium Channel Carbonic Anhydrase	Neurological Disease
Topiramate D12 (Standard) is the analytical standard of Topiramate D12. This product is intended for research and analytical applications. Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .

HY-W042039

Methyl homoveratrate	Calcium Channel	Cardiovascular Disease
Methyl homoveratrate, a metabolite of RWJ-26240 in vivo, can be identified in plasma, urine and faecal extract. McN5691 (RWJ-26240) is a voltage-sensitive calcium channel blocker .

HY-U00388

α2δ ligand 1	Calcium Channel	Neurological Disease
α2δ ligand 1 is a ligand to the α2δ-1 subunit of voltage-sensitive calcium channel, extracted from patent US20040186177.

HY-12650S1

Mirogabalin-d4 DS5565-d₄	Isotope-Labeled Compounds Calcium Channel	Neurological Disease
Mirogabalin-d₄ (DS5565-d₄) is a deuterated compound of Mirogabalin (HY-12650), a ligand that selectively targets the voltage-sensitive calcium channel complex α2δ-1 .

HY-12650

Mirogabalin 5 Publications Verification DS5565	Calcium Channel	Neurological Disease
Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS.

HY-B0122

Topiramate 4 Publications Verification McN 4853; RWJ 17021	iGluR GABA Receptor Sodium Channel Calcium Channel Potassium Channel Carbonic Anhydrase	Neurological Disease
Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .

HY-B0122A

Topiramate lithium McN 4853 lithium; RWJ 17021 lithium	iGluR GABA Receptor Sodium Channel Calcium Channel Potassium Channel Carbonic Anhydrase	Neurological Disease
Topiramate (McN 4853) lithium is a broad-spectrum antiepileptic agent. Topiramate lithium is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .

HY-133195

Nefopam Fenazoxine	Others	Neurological Disease
Nefopam (Fenazoxine) is an orally active, non-opioid and non-steroidal centrally acting analgesic agent. Nefopam blocks voltage-sensitive sodium channels (IC₅₀=27 μM) and modulates glutamatergic transmission in rodents. Nefopam can be used in studies of neuropathic pain, anticonvulsant, as well as the prevention of postoperative shivering and hiccups .

HY-164684

Dichlorobenzamil 3',4'-Dichlorobenzamil; L-594881	Calcium Channel Sodium Channel Na+/Ca2+ Exchanger	Others
Dichlorobenzamil (3',4'-Dichlorobenzamil; L-594881) is an effective Na/Ca exchange inhibitor. Dichlorobenzamil significantly inhibits ⁴⁵Ca uptake mediated by reverse Na/Ca exchange in pancreatic islet cells (IC₅₀ = 18 μM). Dichlorobenzamil can also block K ⁺ channels and voltage-sensitive Ca ²⁺ channels .

HY-12650R

Mirogabalin (Standard)	Calcium Channel	Neurological Disease
Mirogabalin (Standard) is the analytical standard of Mirogabalin. This product is intended for research and analytical applications. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS.

HY-B0122R

Topiramate (Standard)	iGluR GABA Receptor Sodium Channel Calcium Channel Potassium Channel Carbonic Anhydrase	Neurological Disease
Topiramate (Standard) is the analytical standard of Topiramate. This product is intended for research and analytical applications. Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .

HY-125452

DiSBAC10	Fluorescent Dye	Others
DiSBAC10 is a voltage-sensitive fluorescent probe used to study cell membrane electrical activity in FRET assays. In a resting polarized cell, DiSBAC10 resides on the outer leaflet of the membrane where it accepts photons from excited fluorescein-labeled proteins and re-emits the photons at a higher wavelength. Depolarization of the cell causes rapid translocation of DiSBAC10 to the inner leaflet of the membrane, thereby increasing the distance between fluorophores and reducing the FRET signal.

HY-140677

mPEG-amine (MW 5000) mPEG-NH2 (MW 5000)	PROTAC Linkers	Cancer
mPEG-amine (mPEG-NH2) (MW 5000) is a modifier that can replace the sulfonic acid portion of the dye molecule to increase the water solubility of long-wavelength voltage-sensitive dyes (VSD) or Pittsburgh (PGH) dyes. mPEG-amine can also form amide bonds with carboxyl groups on the surface of microspheres under the mediation of EDC and Sulfo-NHS to form a PEG coating on the surface of fluorescent microspheres for large-scale rotational cytoplasmic flow studies .

HY-12650S

Mirogabalin-13C2,d1 (Mixture of Diastereomers) DS5565-¹³C₂,d₁ (Mixture of Diastereomers)	Isotope-Labeled Compounds	Others
Mirogabalin-13C2,d1 (Mixture of Diastereomers) is a C13 and deuterium labeled Mirogabalin. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS .

HY-B0122S

Topiramate-13C6 McN 4853-¹³C₆; RWJ 17021-¹³C₆	Isotope-Labeled Compounds Potassium Channel iGluR Sodium Channel GABA Receptor Carbonic Anhydrase Calcium Channel	Neurological Disease
Topiramate-13C6 (McN 4853-13C6) is the ¹³C labeled isotope of Topiramate (HY-B0122). Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .

HY-12545

Brevetoxin-3 PbTx-3	Sodium Channel	Inflammation/Immunology
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na ⁺?channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain) . Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na ⁺?channels, inhibits the inactivation of Na ⁺ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation .

HY-103318

PD173212 1 Publications Verification	Calcium Channel	Neurological Disease
PD173212 is a selective *N-type voltage sensitive* calcium channel (VSCC) blocker, with an IC₅₀** of 36 nM in IMR-32 assays.

HY-133614

Dihydroisopimaric acid	Potassium Channel	Others
Dihydroisopimaric acid activates large conductance Ca ²⁺ activated K ⁺ (BK) channels alphabeta1 in the direct measurement of BKalphabeta1 opening under whole-cell voltage clamp .

Cat. No.	Product Name

HY-L118

Sodium Channel Blocker Library	129 compounds
Sodium channels conduct sodium ions (Na+) through a cell's plasma membrane that are the source of excitatory currents for the nervous system and muscle. Na channels are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). Dysfunction in voltage-gated sodium channels correlates with neurological and cardiac diseases, including epilepsy, myopathies, pain and cardiac arrhythmias. Sodium channel blockers are used in the treatment of cardiac arrhythmia, pain and convulsion. MCE offers a unique collection of 129 sodium channel blocker and antagonists, all of which have the identified inhibitory effect on sodium channels. MCE Sodium Channel Blocker Library can be used for neurological and cardiac diseases drug discovery and sodium channel research.

Sodium Channel Blocker Library

129 compounds

Sodium channels conduct sodium ions (Na+) through a cell's plasma membrane that are the source of excitatory currents for the nervous system and muscle. Na channels are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). Dysfunction in voltage-gated sodium channels correlates with neurological and cardiac diseases, including epilepsy, myopathies, pain and cardiac arrhythmias. Sodium channel blockers are used in the treatment of cardiac arrhythmia, pain and convulsion.

MCE offers a unique collection of 129 sodium channel blocker and antagonists, all of which have the identified inhibitory effect on sodium channels. MCE Sodium Channel Blocker Library can be used for neurological and cardiac diseases drug discovery and sodium channel research.

Cat. No.	Product Name	Type

HY-D1512

Oxonol 595	Fluorescent Dyes/Probes
Oxonol 595 is a voltage-sensitive fluorescent dye .

HY-D1092

DiBAC4(5)	Fluorescent Dyes/Probes
DiBaC4(5) is a fluorescent voltage-sensitive dye that can be used to monitor the transmembrane potentials when Papain-dissociated retinal cells from adult zebrafish were exposed to GABAergic ligands. DiBaC4(5) is a potential-sensitive fluorescence dye .

HY-101892

DiBAC4(3) 5+ Cited Publications	Fluorescent Dyes/Probes
DiBAC4(3) is a voltage-sensitive fluorescent dye (λ_ex=490 nm, λ_em=505 nm).

HY-D1427

Di-2-ANEPEQ	Fluorescent Dyes/Probes
Di-2-ANEPEQ is a voltage sensitive membrane potential fluorescence dye. Di-2-ANEPEQ can be used for the evaluation of voltage-sensitive fluorescence dyes for monitoring neuronal activity in the embryonic central nervous system .

HY-101891

Di-8-ANEPPS 1 Publications Verification	Fluorescent Dyes/Probes
Di-8-ANEPPS is a naphthylstyryl voltage-sensitive dye, shifting both their fluorescence excitation and emission spectra upon changes in V_m .

HY-129763

Di-4-ANEPPS	Dyes
Di-4-ANEPPS is a voltage-sensitive dye in membrane potential. Di-4-ANEPPS allows reaching a time resolution better than 1 ms and exhibits changes in fluorescence of up to 10% per 100 mV. Di-4-ANEPPS is a common tool for mapping cardiac electrical activity. Di-4-ANEPPS demonstrate significant direct irreversible effect on spontaneous heart rate and ventricular impulse conduction in rabbit isolated heart model .

Di-4-ANEPPS

Dyes

Di-4-ANEPPS is a voltage-sensitive dye in membrane potential. Di-4-ANEPPS allows reaching a time resolution better than 1 ms and exhibits changes in fluorescence of up to 10% per 100 mV. Di-4-ANEPPS is a common tool for mapping cardiac electrical activity. Di-4-ANEPPS demonstrate significant direct irreversible effect on spontaneous heart rate and ventricular impulse conduction in rabbit isolated heart model .

HY-114958

RH 421	Fluorescent Dyes/Probes
RH 421 is a voltage-sensitive styryl dye that can penetrate through the lipid bilayers. RH 421 is a chromogenic substrate for β-galactosidase .

HY-125452

DiSBAC10	Fluorescent Dyes/Probes
DiSBAC10 is a voltage-sensitive fluorescent probe used to study cell membrane electrical activity in FRET assays. In a resting polarized cell, DiSBAC10 resides on the outer leaflet of the membrane where it accepts photons from excited fluorescein-labeled proteins and re-emits the photons at a higher wavelength. Depolarization of the cell causes rapid translocation of DiSBAC10 to the inner leaflet of the membrane, thereby increasing the distance between fluorophores and reducing the FRET signal.

DiSBAC10

Fluorescent Dyes/Probes

DiSBAC10 is a voltage-sensitive fluorescent probe used to study cell membrane electrical activity in FRET assays. In a resting polarized cell, DiSBAC10 resides on the outer leaflet of the membrane where it accepts photons from excited fluorescein-labeled proteins and re-emits the photons at a higher wavelength. Depolarization of the cell causes rapid translocation of DiSBAC10 to the inner leaflet of the membrane, thereby increasing the distance between fluorophores and reducing the FRET signal.

Cat. No.	Product Name	Type

HY-140677

mPEG-amine (MW 5000) mPEG-NH2 (MW 5000)	Drug Delivery
mPEG-amine (mPEG-NH2) (MW 5000) is a modifier that can replace the sulfonic acid portion of the dye molecule to increase the water solubility of long-wavelength voltage-sensitive dyes (VSD) or Pittsburgh (PGH) dyes. mPEG-amine can also form amide bonds with carboxyl groups on the surface of microspheres under the mediation of EDC and Sulfo-NHS to form a PEG coating on the surface of fluorescent microspheres for large-scale rotational cytoplasmic flow studies .

mPEG-amine (MW 5000)

mPEG-NH2 (MW 5000)

Drug Delivery

mPEG-amine (mPEG-NH2) (MW 5000) is a modifier that can replace the sulfonic acid portion of the dye molecule to increase the water solubility of long-wavelength voltage-sensitive dyes (VSD) or Pittsburgh (PGH) dyes. mPEG-amine can also form amide bonds with carboxyl groups on the surface of microspheres under the mediation of EDC and Sulfo-NHS to form a PEG coating on the surface of fluorescent microspheres for large-scale rotational cytoplasmic flow studies .

HY-111157

Dezinamide AHR11748; AN051; ADD94057	Cell Assay Reagents
Dezinamide (ADD94057) is an antiepileptic agent. Dezinamide binds to the voltage-sensitive sodium channel .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-12545

Brevetoxin-3 PbTx-3	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Sodium Channel
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na ⁺?channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain) . Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na ⁺?channels, inhibits the inactivation of Na ⁺ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation .

HY-N12093

Cevadine	Structural Classification Alkaloids Other Alkaloids Source classification Veratrum oblongum Loes. Plants Melanthiaceae	Sodium Channel Parasite
Cevadine is a voltage-sensitive sodium channel agonist. Cevadine has insecticidal activity .

Cat. No.	Product Name	Chemical Structure

HY-12650S1

Mirogabalin-d4
Mirogabalin-d₄ (DS5565-d₄) is a deuterated compound of Mirogabalin (HY-12650), a ligand that selectively targets the voltage-sensitive calcium channel complex α2δ-1 .

HY-12650S

Mirogabalin-13C2,d1 (Mixture of Diastereomers)
Mirogabalin-13C2,d1 (Mixture of Diastereomers) is a C13 and deuterium labeled Mirogabalin. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS .

HY-B0122S

Topiramate-13C6

Topiramate-13C6 (McN 4853-13C6) is the ¹³C labeled isotope of Topiramate (HY-B0122). Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

voltage-sensitive

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products