2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. Seladelpar Lysine dihydrate

Seladelpar Lysine dihydrate  (Synonyms: MBX-8025 Lysine dihydrate; RWJ-800025 Lysine dihydrate)

Cat. No.: HY-19522C Purity: ≥98.0%
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Seladelpar (MBX-8025) Lysine dihydrate is the Lysine dihydrate salt form of Seladelpar (HY-19522). Seladelpar Lysine dihydrate is an orally active agonist for potent PPAR-δ, with EC50 of 2 nM. Seladelpar Lysine dihydrate shows more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively. Seladelpar Lysine dihydrate can be used for the study of primary biliary cholangitis. Seladelpar Lysine dihydrate normalizes hyperglycemia, hyperinsulinemia, glucose, serum lipids and cholesterol levels, ameliorates the nonalcoholic steatohepatitis in mouse model.

For research use only. We do not sell to patients.

Seladelpar Lysine dihydrate Chemical Structure

Seladelpar Lysine dihydrate Chemical Structure

CAS No. : 928821-40-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Seladelpar Lysine dihydrate:

Seladelpar Lysine dihydrate Related Antibodies

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Description

Seladelpar (MBX-8025) Lysine dihydrate is the Lysine dihydrate salt form of Seladelpar (HY-19522). Seladelpar Lysine dihydrate is an orally active agonist for potent PPAR-δ, with EC50 of 2 nM. Seladelpar Lysine dihydrate shows more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively. Seladelpar Lysine dihydrate can be used for the study of primary biliary cholangitis. Seladelpar Lysine dihydrate normalizes hyperglycemia, hyperinsulinemia, glucose, serum lipids and cholesterol levels, ameliorates the nonalcoholic steatohepatitis in mouse model[1][2].

IC50 & Target

PPARδ

2 nM (EC50)

Molecular Weight

626.68

Formula

C27H41F3N2O9S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CCCCN)C(O)=O.O=C(O)COC1=CC=C(SC[C@H](OCC)COC2=CC=C(C(F)(F)F)C=C2)C=C1C.O.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Seladelpar Lysine dihydrate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Seladelpar Lysine dihydrate928821-40-3MBX-8025 Lysine dihydrateRWJ-800025 Lysine dihydratePPARPeroxisome proliferator-activated receptorsinsulin resistancediabetesatherogenic dyslipidemiaonalcoholic steatohepatitisNASHInhibitorinhibitorinhibit

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