Seladelpar (lysine) (Synonyms: MBX-8025 (lysine))

Cat. No.: HY-19522B Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Seladelpar (MBX-8025) lysine is an orally active, potent and specific PPARδ agonist with an EC₅₀ of 2 nM. Seladelpar lysine shows more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively. Seladelpar lysine can be used for the study of primary biliary cholangitis.

For research use only. We do not sell to patients.

Seladelpar (lysine) Chemical Structure

CAS No. : 928821-41-4

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Other Forms of Seladelpar (lysine):

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PPARα PPARβ/δ PPARγ PPAR PPARδ

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

590.65

Formula

C₂₇H₃₇F₃N₂O₇S

CAS No.

928821-41-4

Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CCCCN)C(O)=O.O=C(O)COC1=CC=C(SC[C@H](OCC)COC2=CC=C(C(F)(F)F)C=C2)C=C1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (84.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6930 mL	8.4653 mL	16.9305 mL
5 mM	0.3386 mL	1.6930 mL	3.3861 mL
10 mM	0.1693 mL	0.8465 mL	1.6930 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (243 KB) HNMR (298 KB) LCMS (92 KB)

Handling Instructions (2659 KB)

References

[1]. Bays HE, et al. MBX-8025, a novel peroxisome proliferator receptor-delta agonist: lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin. J Clin Endocrinol Metab. 2011 Sep;96(9):2889-97. [Content Brief]

[2]. Haczeyni F, et al. The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice. Hepatol Commun. 2017 Jul 31;1(7):663-674. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6930 mL	8.4652 mL	16.9305 mL	42.3262 mL
	5 mM	0.3386 mL	1.6930 mL	3.3861 mL	8.4652 mL
	10 mM	0.1693 mL	0.8465 mL	1.6930 mL	4.2326 mL
	15 mM	0.1129 mL	0.5643 mL	1.1287 mL	2.8217 mL
	20 mM	0.0847 mL	0.4233 mL	0.8465 mL	2.1163 mL
	25 mM	0.0677 mL	0.3386 mL	0.6772 mL	1.6930 mL
	30 mM	0.0564 mL	0.2822 mL	0.5643 mL	1.4109 mL
	40 mM	0.0423 mL	0.2116 mL	0.4233 mL	1.0582 mL
	50 mM	0.0339 mL	0.1693 mL	0.3386 mL	0.8465 mL
	60 mM	0.0282 mL	0.1411 mL	0.2822 mL	0.7054 mL
	80 mM	0.0212 mL	0.1058 mL	0.2116 mL	0.5291 mL

Seladelpar (lysine) Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Seladelpar (lysine)928821-41-4MBX-8025 (lysine)PPARPeroxisome proliferator-activated receptorsorallyactiveinsulinresistancediabetesatherogenicdyslipidemiaInhibitorinhibitorinhibit

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