2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Selatinib

Selatinib is a reversible and orally active dual EGFR and ErbB2 inhibitor with IC50s of 13 nM and 22.5 nM, respectively. Selatinib has anticancer effects.

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Selatinib Chemical Structure

Selatinib Chemical Structure

CAS No. : 1275595-86-2

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Based on 1 publication(s) in Google Scholar

Selatinib Related Antibodies

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • Biological Activity

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Description

Selatinib is a reversible and orally active dual EGFR and ErbB2 inhibitor with IC50s of 13 nM and 22.5 nM, respectively. Selatinib has anticancer effects[1].

IC50 & Target[1]

EGFR

13 nM (IC50)

ErbB2

22.5 nM (IC50)

Clinical Trial
Molecular Weight

565.06

Formula

C29H26ClFN4O3S
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=S(C)CCNCC1=CC=C(O1)C2=CC3=C(N=CN=C3C=C2)NC4=CC=C(C(Cl)=C4)OCC5=CC=CC(F)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (176.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7697 mL 8.8486 mL 17.6972 mL
5 mM 0.3539 mL 1.7697 mL 3.5394 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7697 mL 8.8486 mL 17.6972 mL 44.2431 mL
5 mM 0.3539 mL 1.7697 mL 3.5394 mL 8.8486 mL
10 mM 0.1770 mL 0.8849 mL 1.7697 mL 4.4243 mL
15 mM 0.1180 mL 0.5899 mL 1.1798 mL 2.9495 mL
20 mM 0.0885 mL 0.4424 mL 0.8849 mL 2.2122 mL
25 mM 0.0708 mL 0.3539 mL 0.7079 mL 1.7697 mL
30 mM 0.0590 mL 0.2950 mL 0.5899 mL 1.4748 mL
40 mM 0.0442 mL 0.2212 mL 0.4424 mL 1.1061 mL
50 mM 0.0354 mL 0.1770 mL 0.3539 mL 0.8849 mL
60 mM 0.0295 mL 0.1475 mL 0.2950 mL 0.7374 mL
80 mM 0.0221 mL 0.1106 mL 0.2212 mL 0.5530 mL
100 mM 0.0177 mL 0.0885 mL 0.1770 mL 0.4424 mL
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Selatinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Selatinib1275595-86-2EGFREpidermal growth factor receptorErbB-1HER1anticancer effect orally activereversibleInhibitorinhibitorinhibit

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