(-)-SHIN1 (Synonyms: (-)-RZ-2994)

Name: (-)-SHIN1
Brand: MedChemExpress
SKU: HY-112066B
Rating: 4.5 (1 reviews)

Cat. No.: HY-112066B Purity: 99.37% ee.: 99.14%: FAQs
Data Sheet SDS COA Handling Instructions

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(-)-SHIN1 ((-)-RZ-2994) is an inactive (−) enantiomer of SHIN1.

For research use only. We do not sell to patients.

(-)-SHIN1 Chemical Structure

CAS No. : 2444764-09-2

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 333	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 333	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 378	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 640	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1357	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2314	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 4005	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (-)-SHIN1:

SHIN1 In-stock
(+)-SHIN1 Get quote

1 Publications Citing Use of MCE (-)-SHIN1

•Immunity. 2021 Aug 10;54(8):1728-1744.e7. [Abstract]

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Biological Activity
Purity & Documentation
References
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Description

(-)-SHIN1 ((-)-RZ-2994) is an inactive (−) enantiomer of SHIN1^[1].

Molecular Weight

400.47

Formula

C₂₄H₂₄N₄O₂

CAS No.

2444764-09-2

Appearance

Solid

Color

White to off-white

SMILES

OCC1=CC(C2=CC=CC=C2)=CC([C@]3(C(C(C)=NN4)=C4OC(N)=C3C#N)C(C)C)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (249.71 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4971 mL	12.4853 mL	24.9707 mL
5 mM	0.4994 mL	2.4971 mL	4.9941 mL
10 mM	0.2497 mL	1.2485 mL	2.4971 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.37% ee.: 99.14%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (253 KB) HNMR (471 KB) NP-HPLC (304 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4971 mL	12.4853 mL	24.9707 mL	62.4266 mL
	5 mM	0.4994 mL	2.4971 mL	4.9941 mL	12.4853 mL
	10 mM	0.2497 mL	1.2485 mL	2.4971 mL	6.2427 mL
	15 mM	0.1665 mL	0.8324 mL	1.6647 mL	4.1618 mL
	20 mM	0.1249 mL	0.6243 mL	1.2485 mL	3.1213 mL
	25 mM	0.0999 mL	0.4994 mL	0.9988 mL	2.4971 mL
	30 mM	0.0832 mL	0.4162 mL	0.8324 mL	2.0809 mL
	40 mM	0.0624 mL	0.3121 mL	0.6243 mL	1.5607 mL
	50 mM	0.0499 mL	0.2497 mL	0.4994 mL	1.2485 mL
	60 mM	0.0416 mL	0.2081 mL	0.4162 mL	1.0404 mL
	80 mM	0.0312 mL	0.1561 mL	0.3121 mL	0.7803 mL
	100 mM	0.0250 mL	0.1249 mL	0.2497 mL	0.6243 mL

(-)-SHIN1 Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-SHIN12444764-09-2(-)-RZ-2994OthersInhibitorinhibitorinhibit

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(-)-SHIN1 (Synonyms: (-)-RZ-2994)

Customer Review

Other Forms of (-)-SHIN1:

(-)-SHIN1 Related Antibodies

1 Publications Citing Use of MCE (-)-SHIN1

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

(-)-SHIN1 Related Classifications

Keywords:

Your Recently Viewed Products:

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