2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. SIRT2-IN-9

SIRT2-IN-9 (compound 12) is a selective inhibitor of SRIT2 with an IC50 value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer.

For research use only. We do not sell to patients.

SIRT2-IN-9 Chemical Structure

SIRT2-IN-9 Chemical Structure

CAS No. : 522650-91-5

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Based on 1 publication(s) in Google Scholar

SIRT2-IN-9 Related Antibodies

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Description

SIRT2-IN-9 (compound 12) is a selective inhibitor of SRIT2 with an IC50 value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer[1].

IC50 & Target

SIRT2

1.3 μM (IC50)

SIRT1

＞300 μM (IC50)

SIRT3

＞300 μM (IC50)

In Vitro

SIRT2-IN-9 (1-100 μM; 15 min) dose-dependently inhibits SRIT2 with an IC50 value of 1.3 μM, and inhibits SRIT1 and SRIT3 with IC50s ＞300 μM[1].
SIRT2-IN-9 (0-50 μM; 72 h) affects cell viability of MCF-7 cells[1].
SIRT2-IN-9 (0-50 μM; 6 h) affects acetylation of α-tubulin protein[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SIRT2-IN-9 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MCF-7 breast cancer cell line
Concentration: 0-50 μM
Incubation Time: 72 hours
Result: Dose-dependently inhibited cell proliferation of MCF-7 breast cancer cells.

Western Blot Analysis[1]

Cell Line: MCF-7 breast cancer cell line
Concentration: 6.25, 12.5, 25 and 50 μM
Incubation Time: 6 hours
Result: Dose-dependently increased acetylation of α-tubulin protein.
Molecular Weight

438.57

Formula

C21H22N6OS2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=NC(CCCC2)=C2S1)CSC3=NN=C4C(N(CCC)C5=C4C=CC=C5)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 4.46 mg/mL (10.17 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2801 mL 11.4007 mL 22.8014 mL
5 mM 0.4560 mL 2.2801 mL 4.5603 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2801 mL 11.4007 mL 22.8014 mL 57.0034 mL
5 mM 0.4560 mL 2.2801 mL 4.5603 mL 11.4007 mL
10 mM 0.2280 mL 1.1401 mL 2.2801 mL 5.7003 mL
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SIRT2-IN-9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIRT2-IN-9522650-91-5SirtuinMCF-7α-tubulinacetylationselectiveAK-7cancerInhibitorinhibitorinhibit

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