2. Epigenetics
  3. Histone Methyltransferase
  4. SKF 91488 dihydrochloride

SKF 91488 dihydrochloride  (Synonyms: Homodimaprit dihydrochloride)

Cat. No.: HY-100967 Purity: 98.62%
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SKF 91488 (Homodimaprit) dihydrochloride is a potent and noncompetitive histamine N-methyltransferase inhibitor with a Ki value of 0.9 microM. SKF 91488 dihydrochloride inhibits the methylation of labeled histamine in mice.

For research use only. We do not sell to patients.

SKF 91488 dihydrochloride Chemical Structure

SKF 91488 dihydrochloride Chemical Structure

CAS No. : 68941-21-9

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5 mg USD 110 In-stock
10 mg USD 175 In-stock
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Based on 1 publication(s) in Google Scholar

SKF 91488 dihydrochloride Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

SKF 91488 (Homodimaprit) dihydrochloride is a potent and noncompetitive histamine N-methyltransferase inhibitor with a Ki value of 0.9 microM. SKF 91488 dihydrochloride inhibits the methylation of labeled histamine in mice[1].

Molecular Weight

248.22

Formula

C7H19Cl2N3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N=C(N)SCCCCN(C)C.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (100.72 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0287 mL 20.1434 mL 40.2868 mL
5 mM 0.8057 mL 4.0287 mL 8.0574 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0287 mL 20.1434 mL 40.2868 mL 100.7171 mL
5 mM 0.8057 mL 4.0287 mL 8.0574 mL 20.1434 mL
10 mM 0.4029 mL 2.0143 mL 4.0287 mL 10.0717 mL
15 mM 0.2686 mL 1.3429 mL 2.6858 mL 6.7145 mL
20 mM 0.2014 mL 1.0072 mL 2.0143 mL 5.0359 mL
25 mM 0.1611 mL 0.8057 mL 1.6115 mL 4.0287 mL
30 mM 0.1343 mL 0.6714 mL 1.3429 mL 3.3572 mL
40 mM 0.1007 mL 0.5036 mL 1.0072 mL 2.5179 mL
50 mM 0.0806 mL 0.4029 mL 0.8057 mL 2.0143 mL
60 mM 0.0671 mL 0.3357 mL 0.6714 mL 1.6786 mL
80 mM 0.0504 mL 0.2518 mL 0.5036 mL 1.2590 mL
100 mM 0.0403 mL 0.2014 mL 0.4029 mL 1.0072 mL
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SKF 91488 dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKF 9148868941-21-9HomodimapritSKF91488SKF-91488Histone MethyltransferaseInhibitorinhibitorinhibit

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