Sophoraflavanone G (Synonyms: Kushenol F)

Name: Sophoraflavanone G
Brand: MedChemExpress
SKU: HY-N1231
Rating: 4.5 (1 reviews)

Cat. No.: HY-N1231 Purity: 99.52%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties.? Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.

For research use only. We do not sell to patients.

Sophoraflavanone G Chemical Structure

CAS No. : 97938-30-2

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
20 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Sophoraflavanone G:

Sophoraflavanone G (Standard) Get quote

1 Publications Citing Use of MCE Sophoraflavanone G

•Genes (Basel). 2024 Feb 4;15(2):204. [Abstract]

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 29.7 μM (MDA-MB-231 cell)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	202.07 nM Compound: SFG	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 552.97 +/-106.74 nM) Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 552.97 +/-106.74 nM)	[PMID: 34496204]
A549	IC₅₀	21.28 μM Compound: SFG	Cytotoxicity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 34496204]
A549	IC₅₀	212.41 nM Compound: SFG	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 1625.4 +/-413.42 nM) Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 1625.4 +/-413.42 nM)	[PMID: 34496204]
A549	IC₅₀	26.19 μM Compound: SFG	Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 34496204]
A549	IC₅₀	318.48 nM Compound: SFG	Chemo-sensitizing activity against human A549 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 376.13 +/-60.17 nM) Chemo-sensitizing activity against human A549 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 376.13 +/-60.17 nM)	[PMID: 34496204]
A549	IC₅₀	329.75 nM Compound: SFG	Chemo-sensitizing activity against human A549 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 376.13 +/-60.17 nM) Chemo-sensitizing activity against human A549 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 376.13 +/-60.17 nM)	[PMID: 34496204]
A549	IC₅₀	382.31 nM Compound: SFG	Chemo-sensitizing activity against human A549 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 376.13 +/-60.17 nM) Chemo-sensitizing activity against human A549 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 376.13 +/-60.17 nM)	[PMID: 34496204]
A549	IC₅₀	397.71 nM Compound: SFG	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 1162.92 +/-250.73 nM) Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 1162.92 +/-250.73 nM)	[PMID: 34496204]
A549	IC₅₀	403.35 nM Compound: SFG	Chemo-sensitizing activity against human A549 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb =555.44 +/-125.7 nM) Chemo-sensitizing activity against human A549 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb =555.44 +/-125.7 nM)	[PMID: 34496204]
A549	IC₅₀	46.29 nM Compound: SFG	Chemo-sensitizing activity against human A549 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 82.47 +/-24.25 nM) Chemo-sensitizing activity against human A549 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 82.47 +/-24.25 nM)	[PMID: 34496204]
A549	IC₅₀	471.59 nM Compound: SFG	Chemo-sensitizing activity against human A549 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb =555.44 +/-125.7 nM) Chemo-sensitizing activity against human A549 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb =555.44 +/-125.7 nM)	[PMID: 34496204]
A549	IC₅₀	509.94 nM Compound: SFG	Chemo-sensitizing activity against human A549 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb =555.44 +/-125.7 nM) Chemo-sensitizing activity against human A549 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb =555.44 +/-125.7 nM)	[PMID: 34496204]
A549	IC₅₀	52.61 nM Compound: SFG	Chemo-sensitizing activity against human A549 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 82.47 +/-24.25 nM) Chemo-sensitizing activity against human A549 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 82.47 +/-24.25 nM)	[PMID: 34496204]
A549	IC₅₀	60.52 nM Compound: SFG	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 552.97 +/-106.74 nM) Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 552.97 +/-106.74 nM)	[PMID: 34496204]
A549	IC₅₀	603.57 nM Compound: SFG	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 1625.4 +/-413.42 nM) Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 1625.4 +/-413.42 nM)	[PMID: 34496204]
A549	IC₅₀	629.51 nM Compound: SFG	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 1162.92 +/-250.73 nM) Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 1162.92 +/-250.73 nM)	[PMID: 34496204]
A549	IC₅₀	67.97 nM Compound: SFG	Chemo-sensitizing activity against human A549 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 82.47 +/-24.25 nM) Chemo-sensitizing activity against human A549 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 82.47 +/-24.25 nM)	[PMID: 34496204]
A549	IC₅₀	692.66 nM Compound: SFG	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 1162.92 +/-250.73 nM) Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 1162.92 +/-250.73 nM)	[PMID: 34496204]
A549	IC₅₀	93.7 nM Compound: SFG	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 552.97 +/-106.74 nM) Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 552.97 +/-106.74 nM)	[PMID: 34496204]
A549	IC₅₀	980.34 nM Compound: SFG	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 1625.4 +/-413.42 nM) Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 1625.4 +/-413.42 nM)	[PMID: 34496204]
HEK293	IC₅₀	1.04 μM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 1.31 +/-0.2 microM) Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 1.31 +/-0.2 microM)	[PMID: 34496204]
HEK293	IC₅₀	1.05 μM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 1.31 +/-0.2 microM) Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 1.31 +/-0.2 microM)	[PMID: 34496204]
HEK293	IC₅₀	1.56 μM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 1.31 +/-0.2 microM) Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 1.31 +/-0.2 microM)	[PMID: 34496204]
HEK293	IC₅₀	1062.4 nM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 787.11 +/-227.51 nM) Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 787.11 +/-227.51 nM)	[PMID: 34496204]
HEK293	IC₅₀	112.05 nM Compound: SFG	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 239.91 +/-25 nM) Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 239.91 +/-25 nM)	[PMID: 34496204]
HEK293	IC₅₀	112.37 nM Compound: SFG	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 558.68 +/-81.31 nM) Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 558.68 +/-81.31 nM)	[PMID: 34496204]
HEK293	IC₅₀	15.23 nM Compound: SFG	Chemo-sensitizing activity against human HEK293 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 15.36 +/-6.18 nM) Chemo-sensitizing activity against human HEK293 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 15.36 +/-6.18 nM)	[PMID: 34496204]
HEK293	IC₅₀	15.38 nM Compound: SFG	Chemo-sensitizing activity against human HEK293 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 15.36 +/-6.18 nM) Chemo-sensitizing activity against human HEK293 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 15.36 +/-6.18 nM)	[PMID: 34496204]
HEK293	IC₅₀	17.01 nM Compound: SFG	Chemo-sensitizing activity against human HEK293 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 15.36 +/-6.18 nM) Chemo-sensitizing activity against human HEK293 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 15.36 +/-6.18 nM)	[PMID: 34496204]
HEK293	IC₅₀	17.86 nM Compound: SFG	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 99.55 +/-7.35 nM) Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 99.55 +/-7.35 nM)	[PMID: 34496204]
HEK293	IC₅₀	2.28 nM Compound: SFG	Chemo-sensitizing activity against human HEK293 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 2.29 +/-0.35 nM) Chemo-sensitizing activity against human HEK293 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 2.29 +/-0.35 nM)	[PMID: 34496204]
HEK293	IC₅₀	2.4 nM Compound: SFG	Chemo-sensitizing activity against human HEK293 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 2.74 +/-0.69 nM) Chemo-sensitizing activity against human HEK293 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 2.74 +/-0.69 nM)	[PMID: 34496204]
HEK293	IC₅₀	2.48 nM Compound: SFG	Chemo-sensitizing activity against human HEK293 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.67 +/-0.39 nM) Chemo-sensitizing activity against human HEK293 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.67 +/-0.39 nM)	[PMID: 34496204]
HEK293	IC₅₀	2.61 nM Compound: SFG	Chemo-sensitizing activity against human HEK293 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.67 +/-0.39 nM) Chemo-sensitizing activity against human HEK293 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.67 +/-0.39 nM)	[PMID: 34496204]
HEK293	IC₅₀	2.65 nM Compound: SFG	Chemo-sensitizing activity against human HEK293 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 2.29 +/-0.35 nM) Chemo-sensitizing activity against human HEK293 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 2.29 +/-0.35 nM)	[PMID: 34496204]
HEK293	IC₅₀	2.7 nM Compound: SFG	Chemo-sensitizing activity against human HEK293 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.67 +/-0.39 nM) Chemo-sensitizing activity against human HEK293 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.67 +/-0.39 nM)	[PMID: 34496204]
HEK293	IC₅₀	2.76 nM Compound: SFG	Chemo-sensitizing activity against human HEK293 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 2.78 +/-0.58 nM) Chemo-sensitizing activity against human HEK293 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 2.78 +/-0.58 nM)	[PMID: 34496204]
HEK293	IC₅₀	2.83 nM Compound: SFG	Chemo-sensitizing activity against human HEK293 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 2.78 +/-0.58 nM) Chemo-sensitizing activity against human HEK293 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 2.78 +/-0.58 nM)	[PMID: 34496204]
HEK293	IC₅₀	2.86 nM Compound: SFG	Chemo-sensitizing activity against human HEK293 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 2.74 +/-0.69 nM) Chemo-sensitizing activity against human HEK293 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 2.74 +/-0.69 nM)	[PMID: 34496204]
HEK293	IC₅₀	2.95 nM Compound: SFG	Chemo-sensitizing activity against human HEK293 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 2.74 +/-0.69 nM) Chemo-sensitizing activity against human HEK293 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 2.74 +/-0.69 nM)	[PMID: 34496204]
HEK293	IC₅₀	2.99 nM Compound: SFG	Chemo-sensitizing activity against human HEK293 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 2.78 +/-0.58 nM) Chemo-sensitizing activity against human HEK293 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 2.78 +/-0.58 nM)	[PMID: 34496204]
HEK293	IC₅₀	238.94 nM Compound: SFG	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 558.68 +/-81.31 nM) Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 558.68 +/-81.31 nM)	[PMID: 34496204]
HEK293	IC₅₀	3.59 nM Compound: SFG	Chemo-sensitizing activity against human HEK293 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 2.29 +/-0.35 nM) Chemo-sensitizing activity against human HEK293 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 2.29 +/-0.35 nM)	[PMID: 34496204]
HEK293	IC₅₀	31.5 nM Compound: SFG	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 99.55 +/-7.35 nM) Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 99.55 +/-7.35 nM)	[PMID: 34496204]
HEK293	IC₅₀	314.87 nM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 260 +/-74.23 nM) Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 260 +/-74.23 nM)	[PMID: 34496204]
HEK293	IC₅₀	323.75 nM Compound: SFG	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 558.68 +/-81.31 nM) Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 558.68 +/-81.31 nM)	[PMID: 34496204]
HEK293	IC₅₀	329.16 nM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 260 +/-74.23 nM) Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 260 +/-74.23 nM)	[PMID: 34496204]
HEK293	IC₅₀	35.13 μM Compound: SFG	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 34496204]
HEK293	IC₅₀	358.29 nM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 787.11 +/-227.51 nM) Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 787.11 +/-227.51 nM)	[PMID: 34496204]
HEK293	IC₅₀	37.55 nM Compound: SFG	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 239.91 +/-25 nM) Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 239.91 +/-25 nM)	[PMID: 34496204]
HEK293	IC₅₀	38.19 nM Compound: SFG	Chemo-sensitizing activity against human HEK293 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 35.17 +/-8.65 nM) Chemo-sensitizing activity against human HEK293 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 35.17 +/-8.65 nM)	[PMID: 34496204]
HEK293	IC₅₀	38.88 nM Compound: SFG	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 99.55 +/-7.35 nM) Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 99.55 +/-7.35 nM)	[PMID: 34496204]
HEK293	IC₅₀	40.08 nM Compound: SFG	Chemo-sensitizing activity against human HEK293 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 35.17 +/-8.65 nM) Chemo-sensitizing activity against human HEK293 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 35.17 +/-8.65 nM)	[PMID: 34496204]
HEK293	IC₅₀	41.99 nM Compound: SFG	Chemo-sensitizing activity against human HEK293 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 35.17 +/-8.65 nM) Chemo-sensitizing activity against human HEK293 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 35.17 +/-8.65 nM)	[PMID: 34496204]
HEK293	IC₅₀	416.09 nM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 260 +/-74.23 nM) Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 260 +/-74.23 nM)	[PMID: 34496204]
HEK293	IC₅₀	49.7 μM Compound: SFG	Cytotoxicity against ABCG2-overexpressing human HEK293/482R cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against ABCG2-overexpressing human HEK293/482R cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 34496204]
HEK293	IC₅₀	847.09 nM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 787.11 +/-227.51 nM) Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 787.11 +/-227.51 nM)	[PMID: 34496204]
HEK293	IC₅₀	99.94 nM Compound: SFG	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 239.91 +/-25 nM) Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 239.91 +/-25 nM)	[PMID: 34496204]
HL-60	IC₅₀	12.5 μM Compound: 3	Cytotoxicity against human HL60 cells after 96 hrs by MTT assay Cytotoxicity against human HL60 cells after 96 hrs by MTT assay	[PMID: 10843587]
KB 3-1	IC₅₀	0.72 nM Compound: SFG	Chemo-sensitizing activity against human KB 3-1 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1.19 +/-0.39 nM) Chemo-sensitizing activity against human KB 3-1 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1.19 +/-0.39 nM)	[PMID: 34496204]
KB 3-1	IC₅₀	0.97 nM Compound: SFG	Chemo-sensitizing activity against human KB 3-1 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1.19 +/-0.39 nM) Chemo-sensitizing activity against human KB 3-1 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1.19 +/-0.39 nM)	[PMID: 34496204]
KB 3-1	IC₅₀	1.08 nM Compound: SFG	Chemo-sensitizing activity against human KB 3-1 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1.19 +/-0.39 nM) Chemo-sensitizing activity against human KB 3-1 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1.19 +/-0.39 nM)	[PMID: 34496204]
KB 3-1	IC₅₀	12.44 nM Compound: SFG	Chemo-sensitizing activity against human KB 3-1 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 13.78 +/-7.63 nM) Chemo-sensitizing activity against human KB 3-1 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 13.78 +/-7.63 nM)	[PMID: 34496204]
KB 3-1	IC₅₀	13.02 nM Compound: SFG	Chemo-sensitizing activity against human KB 3-1 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 13.78 +/-7.63 nM) Chemo-sensitizing activity against human KB 3-1 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 13.78 +/-7.63 nM)	[PMID: 34496204]
KB 3-1	IC₅₀	13.2 nM Compound: SFG	Chemo-sensitizing activity against human KB 3-1 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 13.78 +/-7.63 nM) Chemo-sensitizing activity against human KB 3-1 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 13.78 +/-7.63 nM)	[PMID: 34496204]
KB 3-1	IC₅₀	2.1 nM Compound: SFG	Chemo-sensitizing activity against human KB 3-1 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.29 +/-0.75 nM) Chemo-sensitizing activity against human KB 3-1 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.29 +/-0.75 nM)	[PMID: 34496204]
KB 3-1	IC₅₀	2.14 nM Compound: SFG	Chemo-sensitizing activity against human KB 3-1 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.29 +/-0.75 nM) Chemo-sensitizing activity against human KB 3-1 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.29 +/-0.75 nM)	[PMID: 34496204]
KB 3-1	IC₅₀	2.6 nM Compound: SFG	Chemo-sensitizing activity against human KB 3-1 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.29 +/-0.75 nM) Chemo-sensitizing activity against human KB 3-1 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.29 +/-0.75 nM)	[PMID: 34496204]
KB-V1	IC₅₀	1.7 μM Compound: SFG	Chemo-sensitizing activity against ABCB1-expressing human KB-V1 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.73 +/-0.42 microM) Chemo-sensitizing activity against ABCB1-expressing human KB-V1 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.73 +/-0.42 microM)	[PMID: 34496204]
KB-V1	IC₅₀	1367.2 nM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1745 +/-293.01 nM) Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1745 +/-293.01 nM)	[PMID: 34496204]
KB-V1	IC₅₀	1524.22 nM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1745 +/-293.01 nM) Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1745 +/-293.01 nM)	[PMID: 34496204]
KB-V1	IC₅₀	1724.3 nM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1745 +/-293.01 nM) Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1745 +/-293.01 nM)	[PMID: 34496204]
KB-V1	IC₅₀	2.32 μM Compound: SFG	Chemo-sensitizing activity against ABCB1-expressing human KB-V1 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.73 +/-0.42 microM) Chemo-sensitizing activity against ABCB1-expressing human KB-V1 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.73 +/-0.42 microM)	[PMID: 34496204]
KB-V1	IC₅₀	3.08 μM Compound: SFG	Chemo-sensitizing activity against ABCB1-expressing human KB-V1 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.73 +/-0.42 microM) Chemo-sensitizing activity against ABCB1-expressing human KB-V1 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.73 +/-0.42 microM)	[PMID: 34496204]
KB-V1	IC₅₀	822.27 nM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 758.22 +/-156.56 nM) Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 758.22 +/-156.56 nM)	[PMID: 34496204]
KB-V1	IC₅₀	865.61 nM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 758.22 +/-156.56 nM) Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 758.22 +/-156.56 nM)	[PMID: 34496204]
KB-V1	IC₅₀	978.02 nM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 758.22 +/-156.56 nM) Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 758.22 +/-156.56 nM)	[PMID: 34496204]
NCI/ADR-RES	IC₅₀	3.04 μM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 2.63 +/-0.62 microM) Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 2.63 +/-0.62 microM)	[PMID: 34496204]
NCI/ADR-RES	IC₅₀	3.37 μM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 2.63 +/-0.62 microM) Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 2.63 +/-0.62 microM)	[PMID: 34496204]
NCI/ADR-RES	IC₅₀	3.51 μM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 2.63 +/-0.62 microM) Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 2.63 +/-0.62 microM)	[PMID: 34496204]
NCI/ADR-RES	IC₅₀	4.92 μM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 7.09 +/-0.89 microM) Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 7.09 +/-0.89 microM)	[PMID: 34496204]
NCI/ADR-RES	IC₅₀	4.95 μM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 5.57 +/-0.96 microM) Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 5.57 +/-0.96 microM)	[PMID: 34496204]
NCI/ADR-RES	IC₅₀	5.43 μM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 5.57 +/-0.96 microM) Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 5.57 +/-0.96 microM)	[PMID: 34496204]
NCI/ADR-RES	IC₅₀	5.58 μM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 5.57 +/-0.96 microM) Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 5.57 +/-0.96 microM)	[PMID: 34496204]
NCI/ADR-RES	IC₅₀	6.18 μM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 7.09 +/-0.89 microM) Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 7.09 +/-0.89 microM)	[PMID: 34496204]
NCI/ADR-RES	IC₅₀	7.04 μM Compound: SFG	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 7.09 +/-0.89 microM) Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 7.09 +/-0.89 microM)	[PMID: 34496204]
NCI-H460	IC₅₀	0.43 μM Compound: SFG	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 4.33 +/-1.18 microM) Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 4.33 +/-1.18 microM)	[PMID: 34496204]
NCI-H460	IC₅₀	1.16 μM Compound: SFG	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 4.33 +/-1.18 microM) Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 4.33 +/-1.18 microM)	[PMID: 34496204]
NCI-H460	IC₅₀	1.64 μM Compound: SFG	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 4.33 +/-1.18 microM) Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 4.33 +/-1.18 microM)	[PMID: 34496204]
NCI-H460	IC₅₀	100.27 nM Compound: SFG	Chemo-sensitizing activity against human NCI-H460 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 128.27 +/-22.6 nM) Chemo-sensitizing activity against human NCI-H460 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 128.27 +/-22.6 nM)	[PMID: 34496204]
NCI-H460	IC₅₀	127.03 nM Compound: SFG	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 963.32 +/-120.89 nM) Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 963.32 +/-120.89 nM)	[PMID: 34496204]
NCI-H460	IC₅₀	130.53 nM Compound: SFG	Chemo-sensitizing activity against human NCI-H460 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 279.69 +/-31.94 nM) Chemo-sensitizing activity against human NCI-H460 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 279.69 +/-31.94 nM)	[PMID: 34496204]
NCI-H460	IC₅₀	172.9 nM Compound: SFG	Chemo-sensitizing activity against human NCI-H460 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 279.69 +/-31.94 nM) Chemo-sensitizing activity against human NCI-H460 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 279.69 +/-31.94 nM)	[PMID: 34496204]
NCI-H460	IC₅₀	22.12 μM Compound: SFG	Cytotoxicity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 34496204]
NCI-H460	IC₅₀	29.32 μM Compound: SFG	Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 34496204]
NCI-H460	IC₅₀	358.5 nM Compound: SFG	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 963.32 +/-120.89 nM) Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 963.32 +/-120.89 nM)	[PMID: 34496204]
NCI-H460	IC₅₀	419.28 nM Compound: SFG	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460MX20 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 3262.6 +/-811.81 nM) Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460MX20 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 3262.6 +/-811.81 nM)	[PMID: 34496204]
NCI-H460	IC₅₀	45.02 nM Compound: SFG	Chemo-sensitizing activity against human NCI-H460 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 128.27 +/-22.6 nM) Chemo-sensitizing activity against human NCI-H460 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 128.27 +/-22.6 nM)	[PMID: 34496204]
NCI-H460	IC₅₀	451.72 nM Compound: SFG	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 3262.6 +/-811.81 nM) Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 3262.6 +/-811.81 nM)	[PMID: 34496204]
NCI-H460	IC₅₀	506.03 nM Compound: SFG	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 963.32 +/-120.89 nM) Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 963.32 +/-120.89 nM)	[PMID: 34496204]
NCI-H460	IC₅₀	76.5 nM Compound: SFG	Chemo-sensitizing activity against human NCI-H460 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 128.27 +/-22.6 nM) Chemo-sensitizing activity against human NCI-H460 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 128.27 +/-22.6 nM)	[PMID: 34496204]
NCI-H460	IC₅₀	8.8 nM Compound: SFG	Chemo-sensitizing activity against human NCI-H460 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 20.7 +/-6.32 nM) Chemo-sensitizing activity against human NCI-H460 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 20.7 +/-6.32 nM)	[PMID: 34496204]
NCI-H460	IC₅₀	801.14 nM Compound: SFG	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 3262.6 +/-811.81 nM) Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 3262.6 +/-811.81 nM)	[PMID: 34496204]
NCI-H460	IC₅₀	9.02 nM Compound: SFG	Chemo-sensitizing activity against human NCI-H460 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 20.7 +/-6.32 nM) Chemo-sensitizing activity against human NCI-H460 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 20.7 +/-6.32 nM)	[PMID: 34496204]
NCI-H460	IC₅₀	9.4 nM Compound: SFG	Chemo-sensitizing activity against human NCI-H460 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 20.7 +/-6.32 nM) Chemo-sensitizing activity against human NCI-H460 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 20.7 +/-6.32 nM)	[PMID: 34496204]
NCI-H460	IC₅₀	93.49 nM Compound: SFG	Chemo-sensitizing activity against human NCI-H460 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 279.69 +/-31.94 nM) Chemo-sensitizing activity against human NCI-H460 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 279.69 +/-31.94 nM)	[PMID: 34496204]
OVCAR-8	IC₅₀	2.4 nM Compound: SFG	Chemo-sensitizing activity against human OVCAR-8 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.62 +/-0.31 nM) Chemo-sensitizing activity against human OVCAR-8 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.62 +/-0.31 nM)	[PMID: 34496204]
OVCAR-8	IC₅₀	2.51 nM Compound: SFG	Chemo-sensitizing activity against human OVCAR-8 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.62 +/-0.31 nM) Chemo-sensitizing activity against human OVCAR-8 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.62 +/-0.31 nM)	[PMID: 34496204]
OVCAR-8	IC₅₀	25.93 nM Compound: SFG	Chemo-sensitizing activity against human OVCAR-8 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 28.73 +/-10.04 nM) Chemo-sensitizing activity against human OVCAR-8 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 28.73 +/-10.04 nM)	[PMID: 34496204]
OVCAR-8	IC₅₀	28.25 nM Compound: SFG	Chemo-sensitizing activity against human OVCAR-8 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 28.73 +/-10.04 nM) Chemo-sensitizing activity against human OVCAR-8 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 28.73 +/-10.04 nM)	[PMID: 34496204]
OVCAR-8	IC₅₀	3.09 nM Compound: SFG	Chemo-sensitizing activity against human OVCAR-8 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.62 +/-0.31 nM) Chemo-sensitizing activity against human OVCAR-8 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.62 +/-0.31 nM)	[PMID: 34496204]
OVCAR-8	IC₅₀	3.45 nM Compound: SFG	Chemo-sensitizing activity against human OVCAR-8 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 6.01 +/-0.77 nM) Chemo-sensitizing activity against human OVCAR-8 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 6.01 +/-0.77 nM)	[PMID: 34496204]
OVCAR-8	IC₅₀	30.24 nM Compound: SFG	Chemo-sensitizing activity against human OVCAR-8 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 28.73 +/-10.04 nM) Chemo-sensitizing activity against human OVCAR-8 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 28.73 +/-10.04 nM)	[PMID: 34496204]
OVCAR-8	IC₅₀	5.73 nM Compound: SFG	Chemo-sensitizing activity against human OVCAR-8 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 6.01 +/-0.77 nM) Chemo-sensitizing activity against human OVCAR-8 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 6.01 +/-0.77 nM)	[PMID: 34496204]
OVCAR-8	IC₅₀	6 nM Compound: SFG	Chemo-sensitizing activity against human OVCAR-8 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 6.01 +/-0.77 nM) Chemo-sensitizing activity against human OVCAR-8 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 6.01 +/-0.77 nM)	[PMID: 34496204]
RAW264.7	IC₅₀	10.9 μM Compound: 9	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess method	[PMID: 26073007]

In Vitro

Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells?in a dose-dependent manner^[1].
Sophoraflavanone G (0 -100 μM; 24 hours) induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome?c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated "intrinsic" pathway^[1]
Sophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner, with an IC₅₀ value of 29.7 ± 5.2 μM^[2]<.br>

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

424.49

Formula

C₂₅H₂₈O₆

CAS No.

97938-30-2

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C[C@@H](C2=CC=C(O)C=C2O)OC3=C(C[C@H](C(C)=C)C/C=C(C)\C)C(O)=CC(O)=C13

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (588.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3558 mL	11.7788 mL	23.5577 mL
5 mM	0.4712 mL	2.3558 mL	4.7115 mL
10 mM	0.2356 mL	1.1779 mL	2.3558 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (4.90 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (4.90 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.52%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (250 KB) LCMS (265 KB)

Handling Instructions (2659 KB)

References

[1]. Li ZY, et al. Sophoraflavanone G Induces Apoptosis in Human Leukemia Cells and Blocks MAPK Activation.Am J Chin Med. 2016;44(1):165-76. [Content Brief]

[2]. Huang WC, et al. Sophoraflavanone G from Sophora flavescens induces apoptosis in triple-negative breast cancer cells.Phytomedicine. 2019 Aug;61:152852. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3558 mL	11.7788 mL	23.5577 mL	58.8942 mL
	5 mM	0.4712 mL	2.3558 mL	4.7115 mL	11.7788 mL
	10 mM	0.2356 mL	1.1779 mL	2.3558 mL	5.8894 mL
	15 mM	0.1571 mL	0.7853 mL	1.5705 mL	3.9263 mL
	20 mM	0.1178 mL	0.5889 mL	1.1779 mL	2.9447 mL
	25 mM	0.0942 mL	0.4712 mL	0.9423 mL	2.3558 mL
	30 mM	0.0785 mL	0.3926 mL	0.7853 mL	1.9631 mL
	40 mM	0.0589 mL	0.2945 mL	0.5889 mL	1.4724 mL
	50 mM	0.0471 mL	0.2356 mL	0.4712 mL	1.1779 mL
	60 mM	0.0393 mL	0.1963 mL	0.3926 mL	0.9816 mL
	80 mM	0.0294 mL	0.1472 mL	0.2945 mL	0.7362 mL
	100 mM	0.0236 mL	0.1178 mL	0.2356 mL	0.5889 mL

Sophoraflavanone G Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sophoraflavanone G97938-30-2Kushenol FApoptosisMDA-MB-231HL60apoptosisanti-infammatoryInhibitorinhibitorinhibit

Please select a local distributor ナミキ商事株式会社コスモ・バイオ株式会社
Product Name			Salutation
Applicant Name *			Email Address *
Phone Number *			Organization Name *
Department *			Requested quantity *
Country or Region *
Remarks

Product Name			Lot #
Applicant Name *			Email Address *
Phone Number			Department *
Organization Name *			Country or Region *
Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Sophoraflavanone G (Synonyms: Kushenol F)

Customer Review

Other Forms of Sophoraflavanone G:

Sophoraflavanone G Related Antibodies

1 Publications Citing Use of MCE Sophoraflavanone G

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Sophoraflavanone G Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Sophoraflavanone G Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report