SR 11302

Name: SR 11302
Brand: MedChemExpress
SKU: HY-15870
Rating: 5.0 (6 reviews)

Cat. No.: HY-15870 Purity: 99.68%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE).

For research use only. We do not sell to patients.

SR 11302 Chemical Structure

CAS No. : 160162-42-5

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 440	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 440	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 790	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1260	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 6 publication(s) in Google Scholar

6 Publications Citing Use of MCE SR 11302

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Biological Activity
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References
Customer Review

Description

IC₅₀ & Target

AP-1^[1]

In Vitro

SR 11302 (SR11302) show strong anti-AP-1 activity with selective binding with RARα and RARγ, but not with RARβ and RXRα^[1].
SR 11302 (SR-11302; 1 μM) inhibits AP-1 transcription factor activity and decreases aldosterone levels by 61.9% in hypoxia-treated cells^[2].
SR 11302 (SR-11302; 2 μM; 48 hours) inhibits Helicobacter pylori (H. pylori)-induced cell proliferation in adenocarcinoma gastric (AGS) cells^[3].
SR 11302 (2 μM; 24 hours) inhibits H. pylori-induced expression of β-catenin and c-myc in AGS cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SR 11302 (SR11302; low dose 0.5 mg/kg and high dose 1 mg/kg body weight; orally gavaged daily) treatment reduces the total vascular lesion number and lesion size in Vldlr^-/- mice in a dose-dependent manner^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Vldlr^-/- mice^[4]
Dosage:	Low dose 0.5 mg/kg and high dose 1 mg/kg body weight
Administration:	Orally gavaged daily from P5 to P15
Result:	High-dose from P5 to P15 reduced the total vascular lesion number by 48% and decreased the lesion size by 40%, without detectable signs of toxicity in mice, including no change in body weight.

Molecular Weight

376.53

Formula

C₂₆H₃₂O₂

CAS No.

160162-42-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)/C=C(C)/C=C/C=C(C1=CC=C(C)C=C1)/C=C/C2=C(C)CCCC2(C)C

Shipping

Shipping with dry ice.

Storage

-80°C, protect from light

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (66.40 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6558 mL	13.2792 mL	26.5583 mL
5 mM	0.5312 mL	2.6558 mL	5.3117 mL
10 mM	0.2656 mL	1.3279 mL	2.6558 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (6.64 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 1% CMC-Na/saline water
Solubility: 2 mg/mL (5.31 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.68%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (246 KB) HNMR (244 KB) RP-HPLC (245 KB) LCMS (95 KB) Elemental Analysis Report (104 KB)

Handling Instructions (2659 KB)

References

[1]. C Huang, et al. Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. Proc Natl Acad Sci U S A. 1997 May 27;94(11):5826-30. [Content Brief]

[2]. Bradley A Maron, et al. Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis. Circulation. 2014 Jul 8;130(2):168-79. [Content Brief]

[3]. Eunyoung Byun, et al. Activation of NF-κB and AP-1 Mediates Hyperproliferation by Inducing β-Catenin and c-Myc in Helicobacter pylori-Infected Gastric Epithelial Cells. Yonsei Med J. 2016 May;57(3):647-51. [Content Brief]

[4]. Ye Sun, et al. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017 Jun 5;214(6):1753-1767. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6558 mL	13.2792 mL	26.5583 mL	66.3958 mL
	5 mM	0.5312 mL	2.6558 mL	5.3117 mL	13.2792 mL
	10 mM	0.2656 mL	1.3279 mL	2.6558 mL	6.6396 mL
	15 mM	0.1771 mL	0.8853 mL	1.7706 mL	4.4264 mL
	20 mM	0.1328 mL	0.6640 mL	1.3279 mL	3.3198 mL
	25 mM	0.1062 mL	0.5312 mL	1.0623 mL	2.6558 mL
	30 mM	0.0885 mL	0.4426 mL	0.8853 mL	2.2132 mL
	40 mM	0.0664 mL	0.3320 mL	0.6640 mL	1.6599 mL
	50 mM	0.0531 mL	0.2656 mL	0.5312 mL	1.3279 mL
	60 mM	0.0443 mL	0.2213 mL	0.4426 mL	1.1066 mL

SR 11302 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR 11302160162-42-5SR11302SR-11302AP-1Activator Protein 1activatorprotein-1retinoicacidresponseelementRARELungCancerretinoidInhibitorinhibitorinhibit

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SR 11302

Customer Review

SR 11302 Related Antibodies

6 Publications Citing Use of MCE SR 11302

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All AP-1 Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

SR 11302 Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

SR 11302 Related Classifications

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Customer Review

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