2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. PDGFR EGFR IGF-1R
  4. SU-4313

SU-4313 is a potent protein tyrosine kinases (PTKs) modulator with IC50s of 14.5 μM, 18.8 μM, 11 μM, 16.9 μM, 8.0 μM for PDGFR, FLK-1, EGFR, HER2 Kinase and IGF-1R, respectively. SU-4313 has the potential for modulating tyrosine kinase signal transduction in order to regulate abnormal cell proliferation.

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SU-4313 Chemical Structure

SU-4313 Chemical Structure

CAS No. : 186611-55-2

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SU-4313 Related Antibodies

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PDGFR PDGFRβ PDGFRα

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

SU-4313 is a potent protein tyrosine kinases (PTKs) modulator with IC50s of 14.5 μM, 18.8 μM, 11 μM, 16.9 μM, 8.0 μM for PDGFR, FLK-1, EGFR, HER2 Kinase and IGF-1R, respectively. SU-4313 has the potential for modulating tyrosine kinase signal transduction in order to regulate abnormal cell proliferation[1].

IC50 & Target[1]

PDGFR

14.5 μM (IC50)

FLK-1

18.8 μM (IC50)

EGFR

11 μM (IC50)

HER2

16.9 μM (IC50)

IGF-1R

8.0 μM (IC50)

Molecular Weight

263.33

Formula

C18H17NO
CAS No.
SMILES

O=C1NC2=C(/C1=C/C3=CC=C(C(C)C)C=C3)C=CC=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SU-4313 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SU-4313186611-55-2SU4313SU 4313PDGFREGFRIGF-1RPlatelet-derived growth factor receptorEpidermal growth factor receptorErbB-1HER1Insulin-like growth factor-1 receptorprotein tyrosine kinasesPTKsFLK-1HER2 Kinasecell proliferationInhibitorinhibitorinhibit

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