SUVN-911

Name: SUVN-911
Brand: MedChemExpress
SKU: HY-136146
Rating: 4.5 (1 reviews)

Cat. No.: HY-136146 Purity: 99.40%: FAQs
Data Sheet SDS COA Handling Instructions

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SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a K_i of 1.5 nM. SUVN-911 has antidepressant activity.

For research use only. We do not sell to patients.

SUVN-911 Chemical Structure

CAS No. : 2414674-71-6

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 388	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 388	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 460	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1080	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1480	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of SUVN-911:

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Description

IC₅₀ & Target

Ki: 1.5 nM (α4β2 receptor)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	> 10 μM Compound: 9h; SUVN-911	Inhibition of recombinant human ERG expressed in HEK293 at -80 mV holding potential by whole-cell patch clamp method Inhibition of recombinant human ERG expressed in HEK293 at -80 mV holding potential by whole-cell patch clamp method	[PMID: 32026697]
HEK293	IC₅₀	7.31 μM Compound: 9h; SUVN-911	Antagonist activity at alpha4beta2 nAChR (unknown origin) expressed in HEK293 cells assessed as reduction in acetylcholine-induced currents at -80 mV holding potential by whole-cell patch clamp method Antagonist activity at alpha4beta2 nAChR (unknown origin) expressed in HEK293 cells assessed as reduction in acetylcholine-induced currents at -80 mV holding potential by whole-cell patch clamp method	[PMID: 32026697]

In Vitro

SUVN-911 displays high selectivity for α4β2 over α3β4 nAChR^[1].
SUVN-911 shows good selectivity against over 70 receptors which includes GPCRs, ion channels, enzymes, peptides, steroids, second messengers, growth factors and prostaglandins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SUVN-911 is devoid of cardiovascular and gastrointestinal side effects^[1].
SUVN-911 (1.0-10.0 mg/kg; p.o.; daily; for 3 days) shows significant antidepressant effects^[1].
SUVN-911 shows metabolic stability in rats^[1].
SUVN-911 (3 mg/kg; p.o.) has shown high oral exposures, longer half-lives and adequate brain penetration in Wistar rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (180-230 g)^[1]
Dosage:	1 mg/kg, 3 mg/kg, 10.0 mg/kg
Administration:	Oral administration, daily, for 3 days
Result:	Showed antidepressant like activity with no signs of tachyphylaxis.

Animal Model:	Male Wistar rats (225 ± 25 g)^[1]
Dosage:	3 mg/kg (Pharmacokinetic Analysis)
Administration:	Oral administration
Result:	AUC=3507 ng*h/mL, T_1/2=3.34 hours.

Clinical Trial

Molecular Weight

261.15

Formula

C₁₁H₁₄Cl₂N₂O

CAS No.

2414674-71-6

Appearance

Solid

Color

Off-white to light yellow

SMILES

ClC1=NC=C(OC[C@H]2N[C@@H]3C[C@@H]3C2)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (478.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8292 mL	19.1461 mL	38.2922 mL
5 mM	0.7658 mL	3.8292 mL	7.6584 mL
10 mM	0.3829 mL	1.9146 mL	3.8292 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.40%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (245 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Ramakrishna Nirogi, et al. Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression. J Med Chem. 2020 Mar 26;63(6):2833-2853. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.8292 mL	19.1461 mL	38.2922 mL	95.7304 mL
	5 mM	0.7658 mL	3.8292 mL	7.6584 mL	19.1461 mL
	10 mM	0.3829 mL	1.9146 mL	3.8292 mL	9.5730 mL
	15 mM	0.2553 mL	1.2764 mL	2.5528 mL	6.3820 mL
	20 mM	0.1915 mL	0.9573 mL	1.9146 mL	4.7865 mL
	25 mM	0.1532 mL	0.7658 mL	1.5317 mL	3.8292 mL
	30 mM	0.1276 mL	0.6382 mL	1.2764 mL	3.1910 mL
	40 mM	0.0957 mL	0.4787 mL	0.9573 mL	2.3933 mL
	50 mM	0.0766 mL	0.3829 mL	0.7658 mL	1.9146 mL
	60 mM	0.0638 mL	0.3191 mL	0.6382 mL	1.5955 mL
	80 mM	0.0479 mL	0.2393 mL	0.4787 mL	1.1966 mL
	100 mM	0.0383 mL	0.1915 mL	0.3829 mL	0.9573 mL

SUVN-911 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SUVN-9112414674-71-6SUVN911SUVN 911nAChRNicotinic acetylcholine receptorsantidepressantdepressionneuronalnicotinicacetylcholineInhibitorinhibitorinhibit

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Complete Stock Solution Preparation Table

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