2. Neuronal Signaling
  3. Cholinesterase (ChE) Amyloid-β
  4. TAE-1

TAE-1 is a potent inhibitor of AChE and BuChE. TAE-1 also inhibits Aβ fibril formation and aggregation. TAE-1 can be used for the researches of Alzheimer's disease.

For research use only. We do not sell to patients.

TAE-1 Chemical Structure

TAE-1 Chemical Structure

CAS No. : 1414469-59-2

Size Price Stock Quantity
5 mg USD 32 In-stock
10 mg USD 50 In-stock
25 mg USD 110 In-stock
50 mg USD 190 In-stock
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Based on 1 publication(s) in Google Scholar

TAE-1 Related Antibodies

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AChE BChE

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Description

TAE-1 is a potent inhibitor of AChE and BuChE. TAE-1 also inhibits Aβ fibril formation and aggregation. TAE-1 can be used for the researches of Alzheimer's disease[1].

IC50 & Target

AChE

 

Molecular Weight

1128.57

Formula

C39H51I3N6O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OCC[N+](C)(C)C)C1=CC=C(OC2=NC(OC3=CC=C(C(OCC[N+](C)(C)C)=O)C=C3)=NC(OC4=CC=C(C(OCC[N+](C)(C)C)=O)C=C4)=N2)C=C1.[I-].[I-].[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (110.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8861 mL 4.4304 mL 8.8608 mL
5 mM 0.1772 mL 0.8861 mL 1.7722 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8861 mL 4.4304 mL 8.8608 mL 22.1519 mL
5 mM 0.1772 mL 0.8861 mL 1.7722 mL 4.4304 mL
10 mM 0.0886 mL 0.4430 mL 0.8861 mL 2.2152 mL
15 mM 0.0591 mL 0.2954 mL 0.5907 mL 1.4768 mL
20 mM 0.0443 mL 0.2215 mL 0.4430 mL 1.1076 mL
25 mM 0.0354 mL 0.1772 mL 0.3544 mL 0.8861 mL
30 mM 0.0295 mL 0.1477 mL 0.2954 mL 0.7384 mL
40 mM 0.0222 mL 0.1108 mL 0.2215 mL 0.5538 mL
50 mM 0.0177 mL 0.0886 mL 0.1772 mL 0.4430 mL
60 mM 0.0148 mL 0.0738 mL 0.1477 mL 0.3692 mL
80 mM 0.0111 mL 0.0554 mL 0.1108 mL 0.2769 mL
100 mM 0.0089 mL 0.0443 mL 0.0886 mL 0.2215 mL
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TAE-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAE-11414469-59-2TAE1TAE 1Cholinesterase (ChE)Amyloid-ββ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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