Taribavirin hydrochloride

Name: Taribavirin hydrochloride
Brand: MedChemExpress
SKU: HY-10545A
Rating: 4.5 (1 reviews)

Cat. No.: HY-10545A Purity: 99.96%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor, has activity against a wide range of viruses, especially the hepatitis C virus and influenza virus. Taribavirin hydrochloride is a Ribavirin proagent, is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells (RBCs) and the development of hemolytic anemia.

For research use only. We do not sell to patients.

Taribavirin hydrochloride Chemical Structure

CAS No. : 40372-00-7

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 760	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1200	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1920	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Taribavirin hydrochloride:

Taribavirin Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Inosine monophosphate dehydrogenase^[1]

In Vitro

Taribavirin hydrochloride (0-2 μM; 24 hours) significantly induces MCF-7 cell death, recording half inhibitory effect (IC₅₀) of 0.756 μM in MCF-7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MCF-7 cells
Concentration:	0 μM, 0.1 μM, 1 μM, 2 μM
Incubation Time:	24 hours
Result:	Decreased MCF-7 cell growth.

Clinical Trial

Molecular Weight

279.68

Formula

C₈H₁₄ClN₅O₄

CAS No.

40372-00-7

Appearance

Solid

Color

White to off-white

SMILES

N=C(C1=NN([C@H]2[C@@H]([C@@H]([C@@H](CO)O2)O)O)C=N1)N.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (357.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5755 mL	17.8776 mL	35.7551 mL
5 mM	0.7151 mL	3.5755 mL	7.1510 mL
10 mM	0.3576 mL	1.7878 mL	3.5755 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.96%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (250 KB) RP-HPLC (210 KB) MS (193 KB)

Handling Instructions (2659 KB)

References

[1]. Abd-Rabou AA, et al. Taribavirin and 5-Fluorouracil-Loaded Pegylated-Lipid Nanoparticle Synthesis, p38 Docking, and Antiproliferative Effects on MCF-7 Breast Cancer. Pharm Res. 2018 Feb 27;35(4):76. [Content Brief]

[2]. Deming P, et al. Taribavirin in the treatment of hepatitis C. Expert Opin Investig Drugs. 2011 Oct;20(10):1435-43. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5755 mL	17.8776 mL	35.7551 mL	89.3879 mL
	5 mM	0.7151 mL	3.5755 mL	7.1510 mL	17.8776 mL
	10 mM	0.3576 mL	1.7878 mL	3.5755 mL	8.9388 mL
	15 mM	0.2384 mL	1.1918 mL	2.3837 mL	5.9592 mL
	20 mM	0.1788 mL	0.8939 mL	1.7878 mL	4.4694 mL
	25 mM	0.1430 mL	0.7151 mL	1.4302 mL	3.5755 mL
	30 mM	0.1192 mL	0.5959 mL	1.1918 mL	2.9796 mL
	40 mM	0.0894 mL	0.4469 mL	0.8939 mL	2.2347 mL
	50 mM	0.0715 mL	0.3576 mL	0.7151 mL	1.7878 mL
	60 mM	0.0596 mL	0.2980 mL	0.5959 mL	1.4898 mL
	80 mM	0.0447 mL	0.2235 mL	0.4469 mL	1.1173 mL
	100 mM	0.0358 mL	0.1788 mL	0.3576 mL	0.8939 mL