2. Immunology/Inflammation TGF-beta/Smad
  3. CD47 TGF-β Receptor
  4. TAX2 peptide

TAX2 peptide is a dodecapeptide based on molecular docking and simulation design, derived from the cell surface receptor CD47 sequence. TAX2 peptide acts as a selective antagonist of TSP-1 (thromboxin-1) interacting with CD47. TAX2 peptide can promote the binding of TSP-1 to CD36, which leads to the destruction of VEGFR2 (vascular endothelial growth factor receptor 2) activation, thereby blocking downstream NO (nitric oxide) signaling, demonstrating anti-angiogenic properties. TAX2 peptide can be used to study angiogenesis and tumor cell interactions in the tumor microenvironment.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

TAX2 peptide Chemical Structure

TAX2 peptide Chemical Structure

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Based on 1 publication(s) in Google Scholar

TAX2 peptide Related Antibodies

Top Publications Citing Use of Products

View All TGF-β Receptor Isoform Specific Products:

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ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

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Description

TAX2 peptide is a dodecapeptide based on molecular docking and simulation design, derived from the cell surface receptor CD47 sequence. TAX2 peptide acts as a selective antagonist of TSP-1 (thromboxin-1) interacting with CD47. TAX2 peptide can promote the binding of TSP-1 to CD36, which leads to the destruction of VEGFR2 (vascular endothelial growth factor receptor 2) activation, thereby blocking downstream NO (nitric oxide) signaling, demonstrating anti-angiogenic properties. TAX2 peptide can be used to study angiogenesis and tumor cell interactions in the tumor microenvironment[1].

Molecular Weight

1263.44

Formula

C51H86N14O19S2
Appearance

Solid

Color

White to off-white

Sequence

Cys-Glu-Val-Ser-Gln-Leu-Leu-Lys-Gly-Asp-Ala-Cys (Disulfide bridge: Cys1-Cys12)
Sequence Shortening

CEVSQLLKGDAC (Disulfide bridge: Cys1-Cys12)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (79.15 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7915 mL 3.9574 mL 7.9149 mL
5 mM 0.1583 mL 0.7915 mL 1.5830 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7915 mL 3.9574 mL 7.9149 mL 19.7872 mL
5 mM 0.1583 mL 0.7915 mL 1.5830 mL 3.9574 mL
10 mM 0.0791 mL 0.3957 mL 0.7915 mL 1.9787 mL
15 mM 0.0528 mL 0.2638 mL 0.5277 mL 1.3191 mL
20 mM 0.0396 mL 0.1979 mL 0.3957 mL 0.9894 mL
25 mM 0.0317 mL 0.1583 mL 0.3166 mL 0.7915 mL
30 mM 0.0264 mL 0.1319 mL 0.2638 mL 0.6596 mL
40 mM 0.0198 mL 0.0989 mL 0.1979 mL 0.4947 mL
50 mM 0.0158 mL 0.0791 mL 0.1583 mL 0.3957 mL
60 mM 0.0132 mL 0.0660 mL 0.1319 mL 0.3298 mL
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TAX2 peptide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAX2 peptideCD47TGF-β ReceptorCluster of Differentiation 47MER6OA3Transforming growth factor beta receptorsmolecular dockingselective antagonistsanti-angiogenesistumor microenvironmentanti-cancer activityInhibitorinhibitorinhibit

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