2. Immunology/Inflammation TGF-beta/Smad
  3. CD47 TGF-β Receptor
  4. TAX2 peptide

TAX2 peptide is a dodecapeptide based on molecular docking and simulation design, derived from the cell surface receptor CD47 sequence. TAX2 peptide acts as a selective antagonist of TSP-1 (thromboxin-1) interacting with CD47. TAX2 peptide can promote the binding of TSP-1 to CD36, which leads to the destruction of VEGFR2 (vascular endothelial growth factor receptor 2) activation, thereby blocking downstream NO (nitric oxide) signaling, demonstrating anti-angiogenic properties. TAX2 peptide can be used to study angiogenesis and tumor cell interactions in the tumor microenvironment.

For research use only. We do not sell to patients.

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TAX2 peptide Chemical Structure

TAX2 peptide Chemical Structure

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TAX2 peptide Related Antibodies

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Description

TAX2 peptide is a dodecapeptide based on molecular docking and simulation design, derived from the cell surface receptor CD47 sequence. TAX2 peptide acts as a selective antagonist of TSP-1 (thromboxin-1) interacting with CD47. TAX2 peptide can promote the binding of TSP-1 to CD36, which leads to the destruction of VEGFR2 (vascular endothelial growth factor receptor 2) activation, thereby blocking downstream NO (nitric oxide) signaling, demonstrating anti-angiogenic properties. TAX2 peptide can be used to study angiogenesis and tumor cell interactions in the tumor microenvironment[1].

Molecular Weight

1263.44

Formula

C51H86N14O19S2
Sequence

Cys-Glu-Val-Ser-Gln-Leu-Leu-Lys-Gly-Asp-Ala-Cys (Disulfide bridge: Cys1-Cys12)
Sequence Shortening

CEVSQLLKGDAC (Disulfide bridge: Cys1-Cys12)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TAX2 peptide Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAX2 peptideCD47TGF-β ReceptorCluster of Differentiation 47MER6OA3Transforming growth factor beta receptorsmolecular dockingselective antagonistsanti-angiogenesistumor microenvironmentanti-cancer activityInhibitorinhibitorinhibit

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