2. PROTAC Apoptosis Autophagy
  3. Ligands for E3 Ligase Autophagy Apoptosis
  4. tDHU, acid

tDHU, acid is a dihydropyrimidinecereblon ligand that contains an E3 ligase ligand and a benzoic acid linker. tDHU, acid can be used as an E3 ubiquitin ligase ligand-Linker conjugate for the development of PROTACs.

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tDHU, acid Chemical Structure

tDHU, acid Chemical Structure

CAS No. : 2377643-37-1

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tDHU, acid Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

tDHU, acid is a dihydropyrimidinecereblon ligand that contains an E3 ligase ligand and a benzoic acid linker. tDHU, acid can be used as an E3 ubiquitin ligase ligand-Linker conjugate for the development of PROTACs[1].

IC50 & Target

cereblon[1]
Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
> 50 μM
Compound: tDHU-CO2H
Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins by cell titer-glo assay
Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins by cell titer-glo assay
[PMID: 35859867]
HEK293 IC50
> 50 μM
Compound: tDHU-CO2H
Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins in presence of CRBN-tracer by nanoBRET assay
Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins in presence of CRBN-tracer by nanoBRET assay
[PMID: 35859867]
HEK293 IC50
1.94 μM
Compound: tDHU-CO2H
Cytotoxicity against permeabilized HEK293 cells assessed as inhibition of cell viability incubated for 30 mins in presence of CRBN-tracer by nanoBRET assay
Cytotoxicity against permeabilized HEK293 cells assessed as inhibition of cell viability incubated for 30 mins in presence of CRBN-tracer by nanoBRET assay
[PMID: 35859867]
Molecular Weight

248.23

Formula

C12H12N2O4
CAS No.
SMILES

O=C(C1=CC=C(C)C(N2C(NC(CC2)=O)=O)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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tDHU, acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

tDHU, acid2377643-37-1Ligands for E3 LigaseAutophagyApoptosisE3 ligase-recruiting MoietyDihydropyrimidineE3 ligase ligandbenzoic acidInhibitorinhibitorinhibit

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