2. Apoptosis Autophagy
  3. Apoptosis Autophagy
  4. Tea polyphenol

Tea polyphenol is the floorboard of phenolic compounds in tea. Tea polyphenol exhibits biological activity including antioxidant and anti-cancer activities, inhibition of cell proliferation, induction of apoptosis, cell cycle arrest and modulation of carcinogen metabolism.

For research use only. We do not sell to patients.

Tea polyphenol Chemical Structure

Tea polyphenol Chemical Structure

CAS No. : 84650-60-2

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Tea polyphenol Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Tea polyphenol

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tea polyphenol is the floorboard of phenolic compounds in tea. Tea polyphenol exhibits biological activity including antioxidant and anti-cancer activities, inhibition of cell proliferation, induction of apoptosis, cell cycle arrest and modulation of carcinogen metabolism[1].

In Vivo

Tea polyphenol (400 mg/(kg∙d) in diet for eight weeks) lowers serum glucose and blood lipids in diabetic cardiomyopathy model rats[1].
Tea polyphenol (400 mg/(kg∙d) in diet) improves spatial cognitive abilities in rats with chronic cerebral hypoperfusion[5].
Tea polyphenol (5-20mg/kg, p.o., for 7days) shows antidepressant-like effects in mice following the forced swimming test (FST) and tail suspension test (TST)[6].
Tea polyphenol (100-400 mg/kg in diet per day) protects mice from Acetaminophen (HY-66005)-induced hepatotoxicity by reducing CYP2E1 and CYP1A2 expression in mice[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diabetic cardiomyopathy model rats[1]
Dosage: 400 mg/(kg∙d)
Administration: in diet for eight weeks
Result: Lowers serum glucose and blood lipids.
Improved myocardial structure and function.
Induced autophagy in rats in a high-fat state (Increased level of Beclin-1 and the ratio of LC3-II to LC3-I).
Clinical Trial
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

[Tea polyphenol]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (Need ultrasonic)

DMSO : 32.5 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 3.25 mg/mL; Clear solution

    This protocol yields a clear solution of ≥ 3.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (32.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 3.25 mg/mL; Clear solution

    This protocol yields a clear solution of ≥ 3.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (32.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

SDS (393 KB)

COA (242 KB)

Handling Instructions (2659 KB)
References
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Tea polyphenol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tea polyphenol84650-60-2ApoptosisAutophagypolyphenolcatechinsantidepressantInhibitorinhibitorinhibit

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