2. Protein Tyrosine Kinase/RTK
  3. Tie VEGFR
  4. TIE-2/VEGFR-2 kinase-IN-2

TIE-2/VEGFR-2 kinase-IN-2 is a potent dual VEGFR2 and Tie-2 inhibitor with pIC50 values of 8.61 and 8.56, respectively. TIE-2/VEGFR-2 kinase-IN-2 is an anti-angiogenic agent and can be used for cancer research.

For research use only. We do not sell to patients.

TIE-2/VEGFR-2 kinase-IN-2 Chemical Structure

TIE-2/VEGFR-2 kinase-IN-2 Chemical Structure

CAS No. : 501693-48-7

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

TIE-2/VEGFR-2 kinase-IN-2 Related Antibodies

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Description

TIE-2/VEGFR-2 kinase-IN-2 is a potent dual VEGFR2 and Tie-2 inhibitor with pIC50 values of 8.61 and 8.56, respectively[1]. TIE-2/VEGFR-2 kinase-IN-2 is an anti-angiogenic agent and can be used for cancer research[2].

IC50 & Target[1]

Tie2

8.56 nM (pIC50)

VEGFR-2

 

Tie-2

 

Molecular Weight

431.34

Formula

C20H13F4N5O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC(C(F)(F)F)=CC=C1F)NC(C=C2)=CC=C2C3=COC4=C3C(N)=NC=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (115.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3184 mL 11.5918 mL 23.1836 mL
5 mM 0.4637 mL 2.3184 mL 4.6367 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3184 mL 11.5918 mL 23.1836 mL 57.9589 mL
5 mM 0.4637 mL 2.3184 mL 4.6367 mL 11.5918 mL
10 mM 0.2318 mL 1.1592 mL 2.3184 mL 5.7959 mL
15 mM 0.1546 mL 0.7728 mL 1.5456 mL 3.8639 mL
20 mM 0.1159 mL 0.5796 mL 1.1592 mL 2.8979 mL
25 mM 0.0927 mL 0.4637 mL 0.9273 mL 2.3184 mL
30 mM 0.0773 mL 0.3864 mL 0.7728 mL 1.9320 mL
40 mM 0.0580 mL 0.2898 mL 0.5796 mL 1.4490 mL
50 mM 0.0464 mL 0.2318 mL 0.4637 mL 1.1592 mL
60 mM 0.0386 mL 0.1932 mL 0.3864 mL 0.9660 mL
80 mM 0.0290 mL 0.1449 mL 0.2898 mL 0.7245 mL
100 mM 0.0232 mL 0.1159 mL 0.2318 mL 0.5796 mL
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TIE-2/VEGFR-2 kinase-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TIE-2/VEGFR-2 kinase-IN-2501693-48-7TieVEGFRAngiopoietin receptorVascular endothelial growth factor receptorVEGFR2Tie-2canceranti-angiogenictumorInhibitorinhibitorinhibit

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