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TINK-IN-1 (Compound 9) is a potent and selective Traf2- and Nck-interacting kinase (TNIK) inhibitor with an IC50 of 8 nM. TINK-IN-1 inhibits colorectal cancer cells viability.

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TINK-IN-1 Chemical Structure

TINK-IN-1 Chemical Structure

CAS No. : 1417795-25-5

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5 mg USD 98 In-stock
10 mg USD 160 In-stock
25 mg USD 320 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

TINK-IN-1 (Compound 9) is a potent and selective Traf2- and Nck-interacting kinase (TNIK) inhibitor with an IC50 of 8 nM. TINK-IN-1 inhibits colorectal cancer cells viability[1].

IC50 & Target

IC50: 8 nM (TNIK), 4.7 μM (hERG), 6.3 μM (β-lactamase)[1]
Molecular Weight

416.47

Formula

C24H24N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CC(C2=CC(NC3=CC=C(N4CCOCC4)C(OC)=C3)=NC=C2)=C(OC)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (300.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4011 mL 12.0057 mL 24.0113 mL
5 mM 0.4802 mL 2.4011 mL 4.8023 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4011 mL 12.0057 mL 24.0113 mL 60.0283 mL
5 mM 0.4802 mL 2.4011 mL 4.8023 mL 12.0057 mL
10 mM 0.2401 mL 1.2006 mL 2.4011 mL 6.0028 mL
15 mM 0.1601 mL 0.8004 mL 1.6008 mL 4.0019 mL
20 mM 0.1201 mL 0.6003 mL 1.2006 mL 3.0014 mL
25 mM 0.0960 mL 0.4802 mL 0.9605 mL 2.4011 mL
30 mM 0.0800 mL 0.4002 mL 0.8004 mL 2.0009 mL
40 mM 0.0600 mL 0.3001 mL 0.6003 mL 1.5007 mL
50 mM 0.0480 mL 0.2401 mL 0.4802 mL 1.2006 mL
60 mM 0.0400 mL 0.2001 mL 0.4002 mL 1.0005 mL
80 mM 0.0300 mL 0.1501 mL 0.3001 mL 0.7504 mL
100 mM 0.0240 mL 0.1201 mL 0.2401 mL 0.6003 mL
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TINK-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TINK-IN-11417795-25-5OthersHCT-116HEK-293DLD1HeLaInhibitorinhibitorinhibit

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