2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. TMX-201

TMX-201 is a TLR7 ligand-phospholipid conjugate. TMX-201 shows potent immune stimulatory activity. TMX-201 can be used for breast cancer and melanoma research.

For research use only. We do not sell to patients.

TMX-201 Chemical Structure

TMX-201 Chemical Structure

CAS No. : 1149339-78-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO In-stock
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10 mg In-stock
25 mg In-stock
50 mg In-stock
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Based on 1 publication(s) in Google Scholar

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Description

TMX-201 is a TLR7 ligand-phospholipid conjugate. TMX-201 shows potent immune stimulatory activity. TMX-201 can be used for breast cancer and melanoma research[1].

IC50 & Target

TLR7

 

In Vitro

TMX-201 is more potent cytokine inducer than Imiquimod (HY-B0180) in both mouse and human mononuclear cells. TMX-201 shows less off-target binding compared to Imiquimod[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

The maximum tolerated dose of TMX-201 by i.v. administration is 75 mg/kg[1].
TMX-201 (4mg/kg, IP) suppresses the growth of established subcutaneous B16 melanoma by 46%, without discernible adverse effects[1].
TMX-201 (IP or intra-tumor administration), in combination with anti-CTLA4 antibody, significantly suppressed lung metastasis formation in the 4T1 breast cancer model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1085.36

Formula

C57H93N6O12P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C1=NC(OCCOC)=N2)CC3=CC=C(C=C3)C(NCCOP(OC[C@@H](COC(CCCCCCC/C=C\CCCCCCCC)=O)OC(CCCCCCC/C=C\CCCCCCCC)=O)(O)=O)=O)NC1=C2N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (46.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9214 mL 4.6068 mL 9.2135 mL
5 mM 0.1843 mL 0.9214 mL 1.8427 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9214 mL 4.6068 mL 9.2135 mL 23.0338 mL
5 mM 0.1843 mL 0.9214 mL 1.8427 mL 4.6068 mL
10 mM 0.0921 mL 0.4607 mL 0.9214 mL 2.3034 mL
15 mM 0.0614 mL 0.3071 mL 0.6142 mL 1.5356 mL
20 mM 0.0461 mL 0.2303 mL 0.4607 mL 1.1517 mL
25 mM 0.0369 mL 0.1843 mL 0.3685 mL 0.9214 mL
30 mM 0.0307 mL 0.1536 mL 0.3071 mL 0.7678 mL
40 mM 0.0230 mL 0.1152 mL 0.2303 mL 0.5758 mL
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TMX-201 Related Classifications

Keywords:

TMX-2011149339-78-5TMX201TMX 201Toll-like Receptor (TLR)subcutaneous B16 melanomalung metastasis4T1 breast cancerTLR7Inhibitorinhibitorinhibit

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