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TNIK-IN-2 is a Traf2- and Nck-interacting protein kinase (TNIK) inhibitor, with an IC50 of 1.3337 μM.

For research use only. We do not sell to patients.

TNIK-IN-2 Chemical Structure

TNIK-IN-2 Chemical Structure

CAS No. : 2754265-76-2

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5 mg USD 220 In-stock
10 mg USD 350 In-stock
25 mg USD 630 In-stock
50 mg USD 945 In-stock
100 mg USD 1325 In-stock
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Based on 1 publication(s) in Google Scholar

TNIK-IN-2 Related Antibodies

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Description

TNIK-IN-2 is a Traf2- and Nck-interacting protein kinase (TNIK) inhibitor, with an IC50 of 1.3337 μM[1].

IC50 & Target

IC50: 1.3337 μM (TNIK)[1]
Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
31.26 μM
Compound: 1
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 3 days by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 3 days by MTT assay
[PMID: 34985886]
In Vitro

TNIK-IN-2 (compound 1) inhibits TNIK, with an IC50 of 31.26 μM in HCT116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TNIK-IN-2 Related Antibodies
Molecular Weight

373.40

Formula

C22H19N3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=CC(NC(C2=CC=C(C=C2OC)C3=CC4=C(NC=C4)N=C3)=O)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (334.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6781 mL 13.3905 mL 26.7809 mL
5 mM 0.5356 mL 2.6781 mL 5.3562 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6781 mL 13.3905 mL 26.7809 mL 66.9523 mL
5 mM 0.5356 mL 2.6781 mL 5.3562 mL 13.3905 mL
10 mM 0.2678 mL 1.3390 mL 2.6781 mL 6.6952 mL
15 mM 0.1785 mL 0.8927 mL 1.7854 mL 4.4635 mL
20 mM 0.1339 mL 0.6695 mL 1.3390 mL 3.3476 mL
25 mM 0.1071 mL 0.5356 mL 1.0712 mL 2.6781 mL
30 mM 0.0893 mL 0.4463 mL 0.8927 mL 2.2317 mL
40 mM 0.0670 mL 0.3348 mL 0.6695 mL 1.6738 mL
50 mM 0.0536 mL 0.2678 mL 0.5356 mL 1.3390 mL
60 mM 0.0446 mL 0.2232 mL 0.4463 mL 1.1159 mL
80 mM 0.0335 mL 0.1674 mL 0.3348 mL 0.8369 mL
100 mM 0.0268 mL 0.1339 mL 0.2678 mL 0.6695 mL
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TNIK-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNIK-IN-22754265-76-2OthersTNIKInhibitorinhibitorinhibit

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