2. Cell Cycle/DNA Damage Apoptosis Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease PI3K/Akt/mTOR
  3. Topoisomerase Apoptosis ROS Kinase Cytochrome P450 Caspase Bcl-2 Family PI3K Akt mTOR
  4. Topo I/II-IN-2

Topo I/II-IN-2 (Compound 3g) is an inhibitor of Topo I and Topo II. Topo I/II-IN-2 inhibits NCI-H446 cells and NCI-H1048 cells with IC50s of 1.30 μM and 1.42 μM, respectively. Topo I/II-IN-2 induces mitochondrial Apoptosis, mitochondrial dysfunction and activity generation. Topo I/II-IN-2 inhibits the PI3K/Akt/mTOR pathway. Topo I/II-IN-2 prevents SCLC (small cell lung cancer) cell proliferation, invasion, and migration in vitro. .

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Topo I/II-IN-2 Chemical Structure

Topo I/II-IN-2 Chemical Structure

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Topo I/II-IN-2 Related Antibodies

Top Publications Citing Use of Products

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Topoisomerase Topo I Topo II

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

View All mTOR Isoform Specific Products:

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mTOR mTORC1 mTORC2

  • Biological Activity

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Description

Topo I/II-IN-2 (Compound 3g) is an inhibitor of Topo I and Topo II. Topo I/II-IN-2 inhibits NCI-H446 cells and NCI-H1048 cells with IC50s of 1.30 μM and 1.42 μM, respectively. Topo I/II-IN-2 induces mitochondrial Apoptosis, mitochondrial dysfunction and activity generation. Topo I/II-IN-2 inhibits the PI3K/Akt/mTOR pathway. Topo I/II-IN-2 prevents SCLC (small cell lung cancer) cell proliferation, invasion, and migration in vitro. [1].
IC50 & Target

Topoisomerase I

 

Topoisomerase II

 

Bcl-2

 

Bax

 

Caspase 3

 

Caspase 9

 

Molecular Weight

418.48

Formula

C25H26N2O4
SMILES

CC(C1)CC(C)CN1CC2=CC(OCO3)=C3C=C2C4=CC(C=CC5=C6OCO5)=C6C=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Topo I/II-IN-2 Related Classifications

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topo I/II-IN-2TopoisomeraseApoptosisROS KinaseCytochrome P450CaspaseBcl-2 FamilyPI3KAktmTORCYPsPhosphoinositide 3-kinasePKBProtein kinase BMammalian target of RapamycinSCLCH446 cellsH1048 cellsproliferation,invasionmigrationmitochondrial apoptosisInhibitorinhibitorinhibit

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