Topoisomerase I inhibitor 8

Name: Topoisomerase I inhibitor 8
Brand: MedChemExpress
SKU: HY-148058
Rating: 4.5 (1 reviews)

Cat. No.: HY-148058 Purity: 95.01%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells.

For research use only. We do not sell to patients.

Topoisomerase I inhibitor 8 Chemical Structure

CAS No. : 210346-40-0

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells^[1].

IC₅₀ & Target

Topoisomerase I

In Vitro

Topoisomerase I inhibitor 8 (compound 57) shows antitumor activities against three cell line cultures with IC₅₀s of 0.22 ng/mL (P388), 2.06 ng/mL (HOC-21), 0.17 ng/mL (QG-56), respectively^[1].
Topoisomerase I inhibitor 8 results the change in DNA from the supercoiled form to the relaxed form in the presence of topoisomerase I, shows stronger effective than SN-38 (HY-13704), with IC₅₀ of compound/IC₅₀ of SN-38=0.51^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

420.43

Formula

C₂₄H₂₁FN₂O₄

CAS No.

210346-40-0

Appearance

Solid

Color

Light yellow to brown

SMILES

CC1=C(F)C=C2C3=C1CCCC3=C4C(C(N5C4)=CC([C@](CC)(O)C(OC6)=O)=C6C5=O)=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (118.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3785 mL	11.8926 mL	23.7852 mL
5 mM	0.4757 mL	2.3785 mL	4.7570 mL
10 mM	0.2379 mL	1.1893 mL	2.3785 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.01%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (257 KB) HNMR (385 KB) RP-HPLC (268 KB) LCMS (99 KB)

Handling Instructions (2659 KB)

References

[1]. Sugimori M, et al. Synthesis and antitumor activity of ring A- and F-modified hexacyclic camptothecin analogues. J Med Chem. 1998 Jun 18;41(13):2308-18. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3785 mL	11.8926 mL	23.7852 mL	59.4629 mL
	5 mM	0.4757 mL	2.3785 mL	4.7570 mL	11.8926 mL
	10 mM	0.2379 mL	1.1893 mL	2.3785 mL	5.9463 mL
	15 mM	0.1586 mL	0.7928 mL	1.5857 mL	3.9642 mL
	20 mM	0.1189 mL	0.5946 mL	1.1893 mL	2.9731 mL
	25 mM	0.0951 mL	0.4757 mL	0.9514 mL	2.3785 mL
	30 mM	0.0793 mL	0.3964 mL	0.7928 mL	1.9821 mL
	40 mM	0.0595 mL	0.2973 mL	0.5946 mL	1.4866 mL
	50 mM	0.0476 mL	0.2379 mL	0.4757 mL	1.1893 mL
	60 mM	0.0396 mL	0.1982 mL	0.3964 mL	0.9910 mL
	80 mM	0.0297 mL	0.1487 mL	0.2973 mL	0.7433 mL
	100 mM	0.0238 mL	0.1189 mL	0.2379 mL	0.5946 mL