2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase II inhibitor 1

Topoisomerase II inhibitor 1 (compound 89) is a highly efficient and selective topoisomerase IIα inhibitor.

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Topoisomerase II inhibitor 1 Chemical Structure

Topoisomerase II inhibitor 1 Chemical Structure

CAS No. : 2375613-31-1

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Topoisomerase II inhibitor 1 Related Antibodies

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Topoisomerase Topo I Topo II

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Description

Topoisomerase II inhibitor 1 (compound 89) is a highly efficient and selective topoisomerase IIα inhibitor[1].

IC50 & Target

Topoisomerase IIα[1]
Cellular Effect
Cell Line Type Value Description References
DU-145 IC50
0.072 μM
Compound: 89
Antiproliferative activity against human DU145 cells measured after 72 hrs by EZ-Cytox assay
Antiproliferative activity against human DU145 cells measured after 72 hrs by EZ-Cytox assay
[PMID: 31398033]
HCC70 IC50
2.083 μM
Compound: 89
Antiproliferative activity against human HCC70 cells measured after 72 hrs by Ez-cytox assay
Antiproliferative activity against human HCC70 cells measured after 72 hrs by Ez-cytox assay
[PMID: 31398033]
HCT-15 IC50
0.014 μM
Compound: 89
Antiproliferative activity against human HCT15 cells measured after 72 hrs by EZ-Cytox assay
Antiproliferative activity against human HCT15 cells measured after 72 hrs by EZ-Cytox assay
[PMID: 31398033]
HeLa IC50
2.46 μM
Compound: 89
Antiproliferative activity against human HeLa cells measured after 72 hrs by EZ-Cytox assay
Antiproliferative activity against human HeLa cells measured after 72 hrs by EZ-Cytox assay
[PMID: 31398033]
MDA-MB-231 IC50
2.7 μM
Compound: 89
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by Ez-cytox assay
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by Ez-cytox assay
[PMID: 31398033]
MDA-MB-436 IC50
2.64 μM
Compound: 89
Antiproliferative activity against human MDA-MB-436 cells measured after 72 hrs by Ez-cytox assay
Antiproliferative activity against human MDA-MB-436 cells measured after 72 hrs by Ez-cytox assay
[PMID: 31398033]
T47D IC50
0.00267 μM
Compound: 89
Antiproliferative activity against human T47D cells measured after 72 hrs by EZ-Cytox assay
Antiproliferative activity against human T47D cells measured after 72 hrs by EZ-Cytox assay
[PMID: 31398033]
Molecular Weight

385.84

Formula

C24H16ClNO2
CAS No.
SMILES

OC1=CC=CC2=C1CC3=C(C4=CC=C(O)C=C4)C=C(C5=CC=CC=C5Cl)N=C32
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Topoisomerase II inhibitor 1 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase II inhibitor 12375613-31-1Topoisomerase II inhibitor1Topoisomerase II inhibitor-1TopoisomeraseEfficientselectiveInhibitorinhibitorinhibit

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