2. Others
  3. Biochemical Assay Reagents
  4. Triacetonamine monohydrate

Triacetonamine monohydrate  (Synonyms: 2,2,6,6-Tetramethyl-4-piperidone monohydrate)

Cat. No.: HY-N1131B Purity: ≥98.0%
Data Sheet
SDS
COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

Triacetonamine (2,2,6,6-Tetramethyl-4-piperidone) monohydrate is used as an intermediate for the synthesis of pharmaceutical products, pesticides and photostabilizers for polymers. Triacetonamine hydrochloride has oral activity and can induce acute liver failure (ALF) in rats.

For research use only. We do not sell to patients.

Triacetonamine monohydrate Chemical Structure

Triacetonamine monohydrate Chemical Structure

CAS No. : 10581-38-1

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
10 g USD 25 In-stock
50 g   Get quote  

Get it by June 6 for select sizes. Order within 15 hrs 52 mins.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Triacetonamine monohydrate:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Triacetonamine monohydrate

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Triacetonamine (2,2,6,6-Tetramethyl-4-piperidone) monohydrate is used as an intermediate for the synthesis of pharmaceutical products, pesticides and photostabilizers for polymers. Triacetonamine hydrochloride has oral activity and can induce acute liver failure (ALF) in rats[1][2].

In Vivo

Triacetonamine (Purchased from MCE; 200 mg, 300 mg, 400 mg/Kg/day; gavage; 2 days) monohydrate shows typical hepatoenteropathology of ALF with 300 mg/Kg/day and 400 mg/Kg/day, while the group of 400 mg/Kg/day had higher mortality[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (half male and female, 6-8 weeks old, 200 ± 10 g)[2]
Dosage: 200 mg, 300 mg, 400 mg/Kg
Administration: Gavage; daily; 2 days
Result: Showed typical hepatoenteropathology of ALF with 300 mg/Kg/day and 400 mg/Kg/day, while the group of 400 mg/Kg/day had higher mortality.
Molecular Weight

173.25

Formula

C9H19NO2
CAS No.
Appearance

Solid

Color

Colorless to light yellow

SMILES

O=C1CC(C)(C)NC(C)(C)C1.[H]O[H]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (577.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.7720 mL 28.8600 mL 57.7201 mL
5 mM 1.1544 mL 5.7720 mL 11.5440 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.7720 mL 28.8600 mL 57.7201 mL 144.3001 mL
5 mM 1.1544 mL 5.7720 mL 11.5440 mL 28.8600 mL
10 mM 0.5772 mL 2.8860 mL 5.7720 mL 14.4300 mL
15 mM 0.3848 mL 1.9240 mL 3.8480 mL 9.6200 mL
20 mM 0.2886 mL 1.4430 mL 2.8860 mL 7.2150 mL
25 mM 0.2309 mL 1.1544 mL 2.3088 mL 5.7720 mL
30 mM 0.1924 mL 0.9620 mL 1.9240 mL 4.8100 mL
40 mM 0.1443 mL 0.7215 mL 1.4430 mL 3.6075 mL
50 mM 0.1154 mL 0.5772 mL 1.1544 mL 2.8860 mL
60 mM 0.0962 mL 0.4810 mL 0.9620 mL 2.4050 mL
80 mM 0.0722 mL 0.3608 mL 0.7215 mL 1.8038 mL
100 mM 0.0577 mL 0.2886 mL 0.5772 mL 1.4430 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Triacetonamine monohydrate Related Classifications

Keywords:

Triacetonamine10581-38-12,2,6,6-Tetramethyl-4-piperidoneBiochemical Assay ReagentsIntermediatepolymersacute liver failureALFTAAInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Triacetonamine monohydrate
Cat. No.:
HY-N1131B
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (479 KB) Français - FR (479 KB) Deutsch - DE (479 KB) Norwegian - NO (479 KB) Español - ES (479 KB) Swedish - SV (479 KB) Italian - IT (479 KB) Portuguese - PT (479 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.