2. Apoptosis NF-κB
  3. Apoptosis Keap1-Nrf2
  4. Tricetin

Tricetin is a potent competitive inhibitor of the Keap1-Nrf2 Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway.

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Tricetin Chemical Structure

Tricetin Chemical Structure

CAS No. : 520-31-0

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Based on 1 publication(s) in Google Scholar

Tricetin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Tricetin

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Description

Tricetin is a potent competitive inhibitor of the Keap1-Nrf2 Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway[1].

Cellular Effect
Cell Line Type Value Description References
Huh-7 CC50
> 50 μM
Compound: 15
Cytotoxicity against human Huh7.5.1 cells by MTT assay
Cytotoxicity against human Huh7.5.1 cells by MTT assay
[PMID: 22445328]
Huh-7 EC50
32.2 μM
Compound: 15
Antiviral activity against HCV JFH-1 J399EM infected in Human Huh7.5.1 cells assessed as suppression of viral replication after 72 hrs by EGFP assay
Antiviral activity against HCV JFH-1 J399EM infected in Human Huh7.5.1 cells assessed as suppression of viral replication after 72 hrs by EGFP assay
[PMID: 22445328]
In Vitro

Tricetin is mainly found in natural plants such as Ginkgo biloba L., Carica papaya L. and Murraya exotica L. Tricetin activates the Nrf2/HO-1 pathway to protect cells from oxidative stress. Tricetin possessed the protective effect on dopamine neurons of C. elegans. Tricetin has cytostatic properties and anti-metastatic activity of various solid tumors[1].
Pretreatment with Tricetin (20, 40, and 80 μM; for 4 hours) significantly improves 6-OHDA (200 μM)-induced SH-SY5Y cells viability and suppresses mitochondria-mediated apoptosis[1].
Tricetin (80 μM; for 1, 2 and 4 h) markedly decreased the expressions of p-JNK and p-p38[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tricetin Related Antibodies

Cell Viability Assay

Cell Line: SH-SY5Y cells
Concentration: 20, 40, and 80 μM
Incubation Time: Pretreatment for 4 h followed by 6-OHDA (200 μM) for 24 h
Result: Significantly increased 6-OHDA-induced SH-SY5Y cells viability.

Western Blot Analysis

Cell Line: SH-SY5Y cells
Concentration: 80 μM
Incubation Time: 1, 2 and 4 h
Result: Markedly decreased the expressions of p-JNK and p-p38. 
Molecular Weight

302.24

Formula

C15H10O7
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C1C=C(C2=CC(O)=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (82.72 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3086 mL 16.5431 mL 33.0863 mL
5 mM 0.6617 mL 3.3086 mL 6.6173 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.19%

SDS (393 KB)

COA (249 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3086 mL 16.5431 mL 33.0863 mL 82.7157 mL
5 mM 0.6617 mL 3.3086 mL 6.6173 mL 16.5431 mL
10 mM 0.3309 mL 1.6543 mL 3.3086 mL 8.2716 mL
15 mM 0.2206 mL 1.1029 mL 2.2058 mL 5.5144 mL
20 mM 0.1654 mL 0.8272 mL 1.6543 mL 4.1358 mL
25 mM 0.1323 mL 0.6617 mL 1.3235 mL 3.3086 mL
30 mM 0.1103 mL 0.5514 mL 1.1029 mL 2.7572 mL
40 mM 0.0827 mL 0.4136 mL 0.8272 mL 2.0679 mL
50 mM 0.0662 mL 0.3309 mL 0.6617 mL 1.6543 mL
60 mM 0.0551 mL 0.2757 mL 0.5514 mL 1.3786 mL
80 mM 0.0414 mL 0.2068 mL 0.4136 mL 1.0339 mL
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Tricetin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tricetin520-31-0ApoptosisKeap1-Nrf2PPIcell viabilityapoptosisheme oxygenase-1Parkinson's diseaseInhibitorinhibitorinhibit

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