2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin polymerization-IN-43

Tubulin polymerization-IN-43 (compound 15h) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-43 disrupts cellular microtubule networks by targeting the Colchicine (HY-16569) site, and promots cell cycle arrest of leukemia cells at G2/M phase and cell apoptosis, as well as inhibiting angiogenesis.

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Tubulin polymerization-IN-43 Chemical Structure

Tubulin polymerization-IN-43 Chemical Structure

CAS No. : 2773345-90-5

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5 mg USD 420 In-stock
10 mg USD 610 In-stock
25 mg USD 985 In-stock
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Based on 1 publication(s) in Google Scholar

Tubulin polymerization-IN-43 Related Antibodies

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Description

Tubulin polymerization-IN-43 (compound 15h) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-43 disrupts cellular microtubule networks by targeting the Colchicine (HY-16569) site, and promots cell cycle arrest of leukemia cells at G2/M phase and cell apoptosis, as well as inhibiting angiogenesis[1].

Molecular Weight

351.30

Formula

C17H13F4N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=CC2=C(N=C(C(F)(F)F)N=C2N(C)C3=CC=C(OC)C=C3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (284.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8466 mL 14.2328 mL 28.4657 mL
5 mM 0.5693 mL 2.8466 mL 5.6931 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8466 mL 14.2328 mL 28.4657 mL 71.1642 mL
5 mM 0.5693 mL 2.8466 mL 5.6931 mL 14.2328 mL
10 mM 0.2847 mL 1.4233 mL 2.8466 mL 7.1164 mL
15 mM 0.1898 mL 0.9489 mL 1.8977 mL 4.7443 mL
20 mM 0.1423 mL 0.7116 mL 1.4233 mL 3.5582 mL
25 mM 0.1139 mL 0.5693 mL 1.1386 mL 2.8466 mL
30 mM 0.0949 mL 0.4744 mL 0.9489 mL 2.3721 mL
40 mM 0.0712 mL 0.3558 mL 0.7116 mL 1.7791 mL
50 mM 0.0569 mL 0.2847 mL 0.5693 mL 1.4233 mL
60 mM 0.0474 mL 0.2372 mL 0.4744 mL 1.1861 mL
80 mM 0.0356 mL 0.1779 mL 0.3558 mL 0.8896 mL
100 mM 0.0285 mL 0.1423 mL 0.2847 mL 0.7116 mL
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Tubulin polymerization-IN-43 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-432773345-90-5Microtubule/Tubulintubulin polymerizationColchicineG2/MangiogenesisInhibitorinhibitorinhibit

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