Tubulin polymerization-IN-43

Cat. No.: HY-149363 Purity: 99.60%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tubulin polymerization-IN-43 (compound 15h) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-43 disrupts cellular microtubule networks by targeting the Colchicine (HY-16569) site, and promots cell cycle arrest of leukemia cells at G2/M phase and cell apoptosis, as well as inhibiting angiogenesis.

For research use only. We do not sell to patients.

Tubulin polymerization-IN-43 Chemical Structure

CAS No. : 2773345-90-5

Size	Price	Stock	Quantity
5 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 610	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 985	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

Molecular Weight

351.30

Formula

C₁₇H₁₃F₄N₃O

CAS No.

2773345-90-5

Appearance

Solid

Color

White to off-white

SMILES

FC1=CC2=C(N=C(C(F)(F)F)N=C2N(C)C3=CC=C(OC)C=C3)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (284.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8466 mL	14.2328 mL	28.4657 mL
5 mM	0.5693 mL	2.8466 mL	5.6931 mL
10 mM	0.2847 mL	1.4233 mL	2.8466 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.60%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (251 KB) HNMR (343 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Wu H, et, al. Discovery of novel N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives as the inhibitors of tubulin polymerization in leukemia cells. Eur J Med Chem. 2023 Aug 5;256:115470. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8466 mL	14.2328 mL	28.4657 mL	71.1642 mL
	5 mM	0.5693 mL	2.8466 mL	5.6931 mL	14.2328 mL
	10 mM	0.2847 mL	1.4233 mL	2.8466 mL	7.1164 mL
	15 mM	0.1898 mL	0.9489 mL	1.8977 mL	4.7443 mL
	20 mM	0.1423 mL	0.7116 mL	1.4233 mL	3.5582 mL
	25 mM	0.1139 mL	0.5693 mL	1.1386 mL	2.8466 mL
	30 mM	0.0949 mL	0.4744 mL	0.9489 mL	2.3721 mL
	40 mM	0.0712 mL	0.3558 mL	0.7116 mL	1.7791 mL
	50 mM	0.0569 mL	0.2847 mL	0.5693 mL	1.4233 mL
	60 mM	0.0474 mL	0.2372 mL	0.4744 mL	1.1861 mL
	80 mM	0.0356 mL	0.1779 mL	0.3558 mL	0.8896 mL
	100 mM	0.0285 mL	0.1423 mL	0.2847 mL	0.7116 mL