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  5. Tyrosylleucine

Tyrosylleucine (Tyr-Leu, YL), an orally active dipeptide, exhibits a potent antidepressant-like activity.

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Tyrosylleucine Chemical Structure

Tyrosylleucine Chemical Structure

CAS No. : 17355-10-1

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Other Forms of Tyrosylleucine:

Tyrosylleucine Related Antibodies

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Description

Tyrosylleucine (Tyr-Leu, YL), an orally active dipeptide, exhibits a potent antidepressant-like activity[1].

In Vivo

Tyrosylleucine (YL), administered orally, intracerebroventricularly, or intraperitoneally exhibits a potent antidepressant-like activity in the forced swim and tail suspension tests in naïve mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ddY mice (24-27 g)[1]
Dosage: 0.1-30 mg/kg, i.p.; 0.1-1.0 nmol/mouse, i.c.v.; 30-100 mg/kg, p.o.
Administration: Administered orally, intracerebroventricularly, or intraperitoneally
Result: Decreased immobility time after intraperitoneal (1-30 mg/kg) and intracerebroventricular (0.3-1 nmol/mouse) administrations in the FST.
Exhibited a potent antidepressant-like activity in the forced swim and tail suspension tests in naïve mice.
Molecular Weight

294.35

Formula

C15H22N2O4
CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (849.33 mM; Need ultrasonic)

DMSO : 250 mg/mL (849.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3973 mL 16.9866 mL 33.9732 mL
5 mM 0.6795 mL 3.3973 mL 6.7946 mL
View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (7.07 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (7.07 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.3973 mL 16.9866 mL 33.9732 mL 84.9329 mL
5 mM 0.6795 mL 3.3973 mL 6.7946 mL 16.9866 mL
10 mM 0.3397 mL 1.6987 mL 3.3973 mL 8.4933 mL
15 mM 0.2265 mL 1.1324 mL 2.2649 mL 5.6622 mL
20 mM 0.1699 mL 0.8493 mL 1.6987 mL 4.2466 mL
25 mM 0.1359 mL 0.6795 mL 1.3589 mL 3.3973 mL
30 mM 0.1132 mL 0.5662 mL 1.1324 mL 2.8311 mL
40 mM 0.0849 mL 0.4247 mL 0.8493 mL 2.1233 mL
50 mM 0.0679 mL 0.3397 mL 0.6795 mL 1.6987 mL
60 mM 0.0566 mL 0.2831 mL 0.5662 mL 1.4155 mL
80 mM 0.0425 mL 0.2123 mL 0.4247 mL 1.0617 mL
100 mM 0.0340 mL 0.1699 mL 0.3397 mL 0.8493 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Tyrosylleucine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tyrosylleucine17355-10-1Tyr-LeuOtherstyrosineleucinec-FosantidepressantInhibitorinhibitorinhibit

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