Vasicine hydrochloride (Synonyms: Peganine hydrochloride)

Name: Vasicine hydrochloride
Brand: MedChemExpress
SKU: HY-N1103A
Rating: 4.5 (1 reviews)

Cat. No.: HY-N1103A Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Vasicine hydrochloride (peganine hydrochloride) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine (peganine) possesses anti- tuberculosis activity.

For research use only. We do not sell to patients.

Vasicine hydrochloride Chemical Structure

CAS No. : 7174-27-8

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 181	Get quote	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 181	Get quote	Estimated Time of Arrival: December 31
Solid
1 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 165	Get quote	Estimated Time of Arrival: December 31
10 mg	USD 275	Get quote	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Vasicine hydrochloride:

(±)-Vasicine Get quote
Vasicine Get quote

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Biological Activity
Purity & Documentation
References
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Description

Vasicine hydrochloride (peganine hydrochloride) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine (peganine) possesses anti- tuberculosis activity^[1].

Molecular Weight

224.69

Formula

C₁₁H₁₃ClN₂O

CAS No.

7174-27-8

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1CCN2C1=NC3=C(C=CC=C3)C2.[H]Cl

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 125 mg/mL (556.32 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (222.53 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4506 mL	22.2529 mL	44.5058 mL
5 mM	0.8901 mL	4.4506 mL	8.9012 mL
10 mM	0.4451 mL	2.2253 mL	4.4506 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.17 mg/mL (9.66 mM); Clear solution

This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.17 mg/mL (9.66 mM); Clear solution

This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.17 mg/mL (9.66 mM); Clear solution

This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (222.53 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (275 KB) SDS (392 KB)

COA (253 KB) HNMR (217 KB) MS (72 KB)

Handling Instructions (2659 KB)

References

[1]. Grange JM, et al. Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro. J Ethnopharmacol. 1996 Jan;50(1):49-53. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	4.4506 mL	22.2529 mL	44.5058 mL	111.2644 mL
	5 mM	0.8901 mL	4.4506 mL	8.9012 mL	22.2529 mL
	10 mM	0.4451 mL	2.2253 mL	4.4506 mL	11.1264 mL
	15 mM	0.2967 mL	1.4835 mL	2.9671 mL	7.4176 mL
	20 mM	0.2225 mL	1.1126 mL	2.2253 mL	5.5632 mL
	25 mM	0.1780 mL	0.8901 mL	1.7802 mL	4.4506 mL
	30 mM	0.1484 mL	0.7418 mL	1.4835 mL	3.7088 mL
	40 mM	0.1113 mL	0.5563 mL	1.1126 mL	2.7816 mL
	50 mM	0.0890 mL	0.4451 mL	0.8901 mL	2.2253 mL
	60 mM	0.0742 mL	0.3709 mL	0.7418 mL	1.8544 mL
	80 mM	0.0556 mL	0.2782 mL	0.5563 mL	1.3908 mL
	100 mM	0.0445 mL	0.2225 mL	0.4451 mL	1.1126 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Vasicine hydrochloride Related Classifications

Inflammation/Immunology Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vasicine7174-27-8PeganineBacterialInhibitorinhibitorinhibit

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Vasicine hydrochloride (Synonyms: Peganine hydrochloride)

Customer Review

Other Forms of Vasicine hydrochloride:

Vasicine hydrochloride Related Antibodies

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•Related Small Molecules:

•Related Proteins:

Biological Activity

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References

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Complete Stock Solution Preparation Table

Vasicine hydrochloride Related Classifications

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