2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. VEGFR-2-IN-29

VEGFR-2-IN-29 (Compound 5) is a VEGFR-2 inhibitor with an IC50 of 16.5 nM.

For research use only. We do not sell to patients.

VEGFR-2-IN-29 Chemical Structure

VEGFR-2-IN-29 Chemical Structure

CAS No. : 62802-77-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO USD 110 In-stock
Solid
5 mg USD 100 In-stock
10 mg USD 170 In-stock
25 mg USD 350 In-stock
50 mg USD 550 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

VEGFR-2-IN-29 Related Antibodies

Top Publications Citing Use of Products

View All VEGFR Isoform Specific Products:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

VEGFR-2-IN-29 (Compound 5) is a VEGFR-2 inhibitor with an IC50 of 16.5 nM[1].

IC50 & Target[1]

VEGFR-2

16.5 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
HUVEC IC50
15.8 nM
Compound: 5
Inhibition of VEGF-induced proliferation in HUVEC cells assessed as BrdU incorporation by ELISA
Inhibition of VEGF-induced proliferation in HUVEC cells assessed as BrdU incorporation by ELISA
[PMID: 20943391]
HUVEC IC50
210 nM
Compound: 5
Inhibition of bEGF-induced proliferation in HUVEC cells assessed as BrdU incorporation by ELISA
Inhibition of bEGF-induced proliferation in HUVEC cells assessed as BrdU incorporation by ELISA
[PMID: 20943391]
In Vitro

VEGFR-2-IN-29 (Compound 5) (72 h) inhibits HUVEC proliferation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VEGFR-2-IN-29 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HUVEC
Concentration:
Incubation Time: 72 h
Result: Showed inhibition with IC50s of 15.8 nM and 210 nM against VEGF- and bFGF-induced HUVEC proliferation.
Molecular Weight

293.28

Formula

C16H11N3O3
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

O=C(NC1=C2N=CC=CC2=CC=C1)C3=CC=CC([N+]([O-])=O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (68.19 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4097 mL 17.0486 mL 34.0971 mL
5 mM 0.6819 mL 3.4097 mL 6.8194 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4097 mL 17.0486 mL 34.0971 mL 85.2428 mL
5 mM 0.6819 mL 3.4097 mL 6.8194 mL 17.0486 mL
10 mM 0.3410 mL 1.7049 mL 3.4097 mL 8.5243 mL
15 mM 0.2273 mL 1.1366 mL 2.2731 mL 5.6829 mL
20 mM 0.1705 mL 0.8524 mL 1.7049 mL 4.2621 mL
25 mM 0.1364 mL 0.6819 mL 1.3639 mL 3.4097 mL
30 mM 0.1137 mL 0.5683 mL 1.1366 mL 2.8414 mL
40 mM 0.0852 mL 0.4262 mL 0.8524 mL 2.1311 mL
50 mM 0.0682 mL 0.3410 mL 0.6819 mL 1.7049 mL
60 mM 0.0568 mL 0.2841 mL 0.5683 mL 1.4207 mL
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VEGFR-2-IN-29 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-2962802-77-1VEGFRVascular endothelial growth factor receptorHUVECquinoline amideInhibitorinhibitorinhibit

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