2. PROTAC
  3. Ligands for E3 Ligase
  4. VH 101, thiol

VH 101, thiol (compound 20) is a VHL ligand for the synthesis of PROTACs.

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VH 101, thiol Chemical Structure

VH 101, thiol Chemical Structure

CAS No. : 2358775-81-0

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VH 101, thiol Related Antibodies

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Description

VH 101, thiol (compound 20) is a VHL ligand for the synthesis of PROTACs[1].

IC50 & Target[1]

VHL

 

Molecular Weight

534.67

Formula

C25H31FN4O4S2
CAS No.
Appearance

Solid

SMILES

O=C(C1(CC1)F)N[C@@H](C(C)(S)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C4=C(N=CS4)C)C=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 98.66%

COA (260 KB) HNMR (321 KB) LCMS (99 KB)

Handling Instructions (2659 KB)
References
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VH 101, thiol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VH 101, thiol2358775-81-0Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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