VH 101, thiol

Cat. No.: HY-47851 Purity: 98.66%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

VH 101, thiol (compound 20) is a VHL ligand for the synthesis of PROTACs.

For research use only. We do not sell to patients.

VH 101, thiol Chemical Structure

CAS No. : 2358775-81-0

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
10 mg	USD 218	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 435	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 700	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1120	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

Biological Activity
Purity & Documentation
References
Customer Review

Description

VH 101, thiol (compound 20) is a VHL ligand for the synthesis of PROTACs^[1].

IC₅₀ & Target^[1]

VHL

Molecular Weight

534.67

Formula

C₂₅H₃₁FN₄O₄S₂

CAS No.

2358775-81-0

Appearance

Solid

SMILES

O=C(C1(CC1)F)N[C@@H](C(C)(S)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C4=C(N=CS4)C)C=C3)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (187.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8703 mL	9.3516 mL	18.7031 mL
5 mM	0.3741 mL	1.8703 mL	3.7406 mL
10 mM	0.1870 mL	0.9352 mL	1.8703 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.66%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (260 KB) HNMR (321 KB) LCMS (99 KB)

Handling Instructions (2659 KB)

References

[1]. Miriam Girardini, et al. Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs. Bioorg Med Chem. 2019 Jun 15;27(12):2466-2479. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8703 mL	9.3516 mL	18.7031 mL	46.7578 mL
	5 mM	0.3741 mL	1.8703 mL	3.7406 mL	9.3516 mL
	10 mM	0.1870 mL	0.9352 mL	1.8703 mL	4.6758 mL
	15 mM	0.1247 mL	0.6234 mL	1.2469 mL	3.1172 mL
	20 mM	0.0935 mL	0.4676 mL	0.9352 mL	2.3379 mL
	25 mM	0.0748 mL	0.3741 mL	0.7481 mL	1.8703 mL
	30 mM	0.0623 mL	0.3117 mL	0.6234 mL	1.5586 mL
	40 mM	0.0468 mL	0.2338 mL	0.4676 mL	1.1689 mL
	50 mM	0.0374 mL	0.1870 mL	0.3741 mL	0.9352 mL
	60 mM	0.0312 mL	0.1559 mL	0.3117 mL	0.7793 mL
	80 mM	0.0234 mL	0.1169 mL	0.2338 mL	0.5845 mL
	100 mM	0.0187 mL	0.0935 mL	0.1870 mL	0.4676 mL

VH 101, thiol Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VH 101, thiol2358775-81-0Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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