WAY-361789 (Synonyms: SEN15924)

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WAY-361789 (SEN15924) is an orally active agonist for α7 nicotinic acetylcholine receptor (α7 nAChR) with an EC₅₀ of 0.18 μM. WAY-361789 improves the cognitive function, exhibits potential in ameliorating Alzheimer’s Disease and schizophrenia.

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WAY-361789 Chemical Structure

CAS No. : 1040718-40-8

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

AChE

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	24.2 μM Compound: 25, SEN15924, WAY-361789	Inhibition of human ERG expressed in CHO cells by IonWorks assay Inhibition of human ERG expressed in CHO cells by IonWorks assay	[PMID: 22468936]
CHO	EC₅₀	3 μM Compound: 25, SEN15924, WAY-361789	Agonist activity at human alpha7 nAChR expressed in CHO cells by whole cell patch clamp assay Agonist activity at human alpha7 nAChR expressed in CHO cells by whole cell patch clamp assay	[PMID: 22468936]
GH4-C1	EC₅₀	0.18 μM Compound: 25, SEN15924, WAY-361789	Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells assessed as calcium influx measured every 1 sec for 1 min followed by every 30 secs for 10 mins by FLIPR assay Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells assessed as calcium influx measured every 1 sec for 1 min followed by every 30 secs for 10 mins by FLIPR assay	[PMID: 22468936]
GH4-C1	EC₅₀	4.4 μM Compound: 25, SEN15924, WAY-361789	Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells by whole cell patch clamp assay Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells by whole cell patch clamp assay	[PMID: 22468936]
HEK293	IC₅₀	> 30 μM Compound: 25, SEN15924, WAY-361789	Antagonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as inhibition of m-chlorophenylbiguanide-induced calcium influx measured every 1 sec for 1 min followed by every 3 secs for 3 mins by FLIPR assay Antagonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as inhibition of m-chlorophenylbiguanide-induced calcium influx measured every 1 sec for 1 min followed by every 3 secs for 3 mins by FLIPR assay	[PMID: 22468936]
SH-SY5Y	IC₅₀	> 30 μM Compound: 25, SEN15924, WAY-361789	Antagonist activity at human alpha3 receptor in SH-SY5Y cells assessed as inhibition of epibatidine-induced membrane potential measured every 1 sec for 1 min followed by every 3 secs for 3 mins by FLIPR assay Antagonist activity at human alpha3 receptor in SH-SY5Y cells assessed as inhibition of epibatidine-induced membrane potential measured every 1 sec for 1 min followed by every 3 secs for 3 mins by FLIPR assay	[PMID: 22468936]
TE-671	IC₅₀	> 30 μM Compound: 25, SEN15924, WAY-361789	Antagonist activity at alpha1beta1deltagamma receptor in human TE671 cells assessed as inhibition of epibatidine-induced membrane potential measured every 1 sec for 1 min followed by every 3 secs for 3 mins by FLIPR assay Antagonist activity at alpha1beta1deltagamma receptor in human TE671 cells assessed as inhibition of epibatidine-induced membrane potential measured every 1 sec for 1 min followed by every 3 secs for 3 mins by FLIPR assay	[PMID: 22468936]

Molecular Weight

413.51

Formula

C₂₂H₃₁N₅O₃

CAS No.

1040718-40-8

SMILES

O=C(NC1=NNC(C2=CC=C(OC)C=C2)=C1)CCCCN3CCN(C(C)=O)CCC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zanaletti R, et al. Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789). J Med Chem. 2012 May 24;55(10):4806-23. [Content Brief]

WAY-361789 Related Classifications

Neurological Disease

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WAY-3617891040718-40-8SEN15924WAY361789WAY 361789SEN 15924SEN-15924Cholinesterase (ChE)Alzheimer's diseaseADschizophreniaorally activeInhibitorinhibitorinhibit

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