2. Metabolic Enzyme/Protease Apoptosis Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage
  3. Liposome Apoptosis TNF Receptor PPAR
  4. 1,2-DLPC

1,2-DLPC  (Synonyms: 1,2-Dilauroyl-sn-glycero-3-phosphocholine)

Cat. No.: HY-107737 Purity: ≥98.0%
COA Handling Instructions

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1,2-DLPC (1,2-Dilauroyl-sn-glycero-3-phosphocholine) is a ligand for LRH-1 agonists. 1,2-DLPC is a phospholipid used in the synthesis of liposomes. 1,2-DLPC enhances fat breakdown and apoptosis in fat cells through a TNFα-dependent pathway, while also inhibiting palmitate-induced insulin resistance through PPARα-mediated inflammation in muscle cells.

For research use only. We do not sell to patients.

1,2-DLPC Chemical Structure

1,2-DLPC Chemical Structure

CAS No. : 18194-25-7

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50 mg USD 80 In-stock
100 mg USD 130 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 1,2-DLPC:

1,2-DLPC Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE 1,2-DLPC

View All TNF Receptor Isoform Specific Products:

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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PPARα PPARβ/δ PPARγ PPAR PPARδ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

1,2-DLPC (1,2-Dilauroyl-sn-glycero-3-phosphocholine) is a ligand for LRH-1 agonists. 1,2-DLPC is a phospholipid used in the synthesis of liposomes. 1,2-DLPC enhances fat breakdown and apoptosis in fat cells through a TNFα-dependent pathway, while also inhibiting palmitate-induced insulin resistance through PPARα-mediated inflammation in muscle cells[1][2][3].

IC50 & Target

PPARα

 

In Vitro

1,2-DLPC (10-50 mg/mL, 24 h) increases the insulin sensitivity of muscle fibers treated with palmitic acid and induces lipolysis in fat cells[3].
1,2-DLPC (10-50 mg/mL, 24 h) treatment increases the expression levels of peroxisome proliferator-activated receptor α (PPARα) in C2C12 muscle cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1,2-DLPC Related Antibodies

Western Blot Analysis[3]

Cell Line: 3T3-L1
Concentration: 10, 50 mg/mL
Incubation Time: 24 h
Result: Enhanced the release of TNF-α and increased the expression of caspase3.

Western Blot Analysis[3]

Cell Line: C2C12
Concentration: 10, 50 mg/mL
Incubation Time: 24 h
Result: Enhanced PPARα expression and inhibited palmitate-induced phosphorylation of inflammatory markers NFκB and IκB.
Molecular Weight

621.83

Formula

C32H64NO8P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCC(OC[C@@H](OC(CCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (160.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6082 mL 8.0408 mL 16.0816 mL
5 mM 0.3216 mL 1.6082 mL 3.2163 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.02 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% EtOH    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (4.02 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (241 KB) HNMR (270 KB) OR (170 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 1.6082 mL 8.0408 mL 16.0816 mL 40.2039 mL
5 mM 0.3216 mL 1.6082 mL 3.2163 mL 8.0408 mL
10 mM 0.1608 mL 0.8041 mL 1.6082 mL 4.0204 mL
15 mM 0.1072 mL 0.5361 mL 1.0721 mL 2.6803 mL
20 mM 0.0804 mL 0.4020 mL 0.8041 mL 2.0102 mL
25 mM 0.0643 mL 0.3216 mL 0.6433 mL 1.6082 mL
30 mM 0.0536 mL 0.2680 mL 0.5361 mL 1.3401 mL
40 mM 0.0402 mL 0.2010 mL 0.4020 mL 1.0051 mL
50 mM 0.0322 mL 0.1608 mL 0.3216 mL 0.8041 mL
60 mM 0.0268 mL 0.1340 mL 0.2680 mL 0.6701 mL
80 mM 0.0201 mL 0.1005 mL 0.2010 mL 0.5025 mL
100 mM 0.0161 mL 0.0804 mL 0.1608 mL 0.4020 mL
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1,2-DLPC Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,2-DLPC18194-25-71,2-Dilauroyl-sn-glycero-3-phosphocholineLiposomeApoptosisTNF ReceptorPPARTumor Necrosis Factor ReceptorTNFRPeroxisome proliferator-activated receptorsLipolysisapoptosismyocyte inflammationInhibitorinhibitorinhibit

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