2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 1,3,7-Trimethyluric acid

1,3,7-Trimethyluric acid is the metabolite of caffeine. The metabolic ratio 1,3,7-Trimethyluric acid to caffeine can be evaluated as a biomarker to describe variability in CYP3A activity in a cohort.

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1,3,7-Trimethyluric acid Chemical Structure

1,3,7-Trimethyluric acid Chemical Structure

CAS No. : 5415-44-1

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5 mg USD 25 In-stock
10 mg USD 38 In-stock
25 mg USD 64 In-stock
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Other Forms of 1,3,7-Trimethyluric acid:

1,3,7-Trimethyluric acid Related Antibodies

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Description

1,3,7-Trimethyluric acid is the metabolite of caffeine. The metabolic ratio 1,3,7-Trimethyluric acid to caffeine can be evaluated as a biomarker to describe variability in CYP3A activity in a cohort[1].

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

210.19

Formula

C8H10N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C)N(C)C2=C(N(C)C(N2)=O)C1=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (118.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7576 mL 23.7880 mL 47.5760 mL
5 mM 0.9515 mL 4.7576 mL 9.5152 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.99%

COA (250 KB) HNMR (229 KB) LCMS (92 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7576 mL 23.7880 mL 47.5760 mL 118.9400 mL
5 mM 0.9515 mL 4.7576 mL 9.5152 mL 23.7880 mL
10 mM 0.4758 mL 2.3788 mL 4.7576 mL 11.8940 mL
15 mM 0.3172 mL 1.5859 mL 3.1717 mL 7.9293 mL
20 mM 0.2379 mL 1.1894 mL 2.3788 mL 5.9470 mL
25 mM 0.1903 mL 0.9515 mL 1.9030 mL 4.7576 mL
30 mM 0.1586 mL 0.7929 mL 1.5859 mL 3.9647 mL
40 mM 0.1189 mL 0.5947 mL 1.1894 mL 2.9735 mL
50 mM 0.0952 mL 0.4758 mL 0.9515 mL 2.3788 mL
60 mM 0.0793 mL 0.3965 mL 0.7929 mL 1.9823 mL
80 mM 0.0595 mL 0.2974 mL 0.5947 mL 1.4868 mL
100 mM 0.0476 mL 0.2379 mL 0.4758 mL 1.1894 mL
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1,3,7-Trimethyluric acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,3,7-Trimethyluric acid5415-44-1Endogenous Metabolitecaffeine metabolitebiomarkerCYP3A activityInhibitorinhibitorinhibit

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