2. Epigenetics PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK
  3. AMPK VEGFR PDGFR
  4. 10Z-Hymenialdisine

10Z-Hymenialdisine  (Synonyms: (Z)-Hymenialdisine; Hymenialdisine)

Cat. No.: HY-N6794 Purity: 97.0%
COA Handling Instructions

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10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities.

For research use only. We do not sell to patients.

10Z-Hymenialdisine Chemical Structure

10Z-Hymenialdisine Chemical Structure

CAS No. : 82005-12-7

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500 μg USD 570 In-stock

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Based on 1 publication(s) in Google Scholar

10Z-Hymenialdisine Related Antibodies

Top Publications Citing Use of Products

View All AMPK Isoform Specific Products:

View All Isoforms
NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

View All VEGFR Isoform Specific Products:

View All Isoforms
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

View All PDGFR Isoform Specific Products:

View All Isoforms
PDGFR PDGFRβ PDGFRα

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities[1].

In Vitro

10Z-Hymenialdisine displays a moderate effect on (ARK5, VEGFR-2, SAK and PDGFR) protein kinases. 10Z-Hymenialdisine shows a potent inhibition of RAF/MEK-1/MAPK cascade with an IC50 value of 6 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

10Z-Hymenialdisine Related Antibodies
Molecular Weight

324.13

Formula

C11H10BrN5O2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1C2=C(C=C(N2)Br)/C(CCN1)=C3C(N=C(N/3)N)=O
Structure Classification
Initial Source

marine sponge Axinella carteri
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 3.24 mg/mL (10.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0852 mL 15.4259 mL 30.8518 mL
5 mM 0.6170 mL 3.0852 mL 6.1704 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.0%

COA (258 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0852 mL 15.4259 mL 30.8518 mL 77.1295 mL
5 mM 0.6170 mL 3.0852 mL 6.1704 mL 15.4259 mL
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10Z-Hymenialdisine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

10Z-Hymenialdisine82005-12-7(Z)-Hymenialdisine HymenialdisineAMPKVEGFRPDGFRAMP-activated protein kinaseVascular endothelial growth factor receptorPlatelet-derived growth factor receptorkinase inhibitoranticancer activitespyrrole alkaloidInhibitorinhibitorinhibit

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