1. Epigenetics PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK
  2. AMPK VEGFR PDGFR
  3. 10Z-Hymenialdisine

10Z-Hymenialdisine  (Synonyms: (Z)-Hymenialdisine; Hymenialdisine)

Cat. No.: HY-N6794 Purity: 97.0%
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10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities.

For research use only. We do not sell to patients.

10Z-Hymenialdisine Chemical Structure

10Z-Hymenialdisine Chemical Structure

CAS No. : 82005-12-7

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500 μg USD 570 In-stock

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Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities[1].

Cellular Effect
Cell Line Type Value Description References
Jurkat IC50
2.41 μM
Compound: 1 (Hymenialdisine)
Inhibition of IL-2 production was determined in Jurkat cells after PMA/PHA activation by Enzyme immunoassay
Inhibition of IL-2 production was determined in Jurkat cells after PMA/PHA activation by Enzyme immunoassay
[PMID: 15214798]
Jurkat IC50
4 μM
Compound: 8; 55, 63
Antiinflammatory activity in PMA induced human Jurkat cells assessed as inhibition of IL-2 production by EIA assay
Antiinflammatory activity in PMA induced human Jurkat cells assessed as inhibition of IL-2 production by EIA assay
[PMID: 36496202]
KB 3-1 IC50
3.1 μM
Compound: HMD; 1a
Cytotoxicity against human KB-3-1 cells by MTT assay
Cytotoxicity against human KB-3-1 cells by MTT assay
[PMID: 33901899]
L5178Y EC50
3.5 μg/mL
Compound: HMD; 1a
Cytotoxicity against mouse L5178Y cells by MTT assay
Cytotoxicity against mouse L5178Y cells by MTT assay
[PMID: 33901899]
LoVo IC50
6 nM
Compound: 8; 55, 63
Inhibition of cell growth in human LoVo cells by SRB assay
Inhibition of cell growth in human LoVo cells by SRB assay
[PMID: 36496202]
MONO-MAC-6 IC50
0.2 μg/mL
Compound: 6
Cytotoxicity against human MONO-MAC 6 cells assessed as [3H]thymidine incorporation after 48 hrs
Cytotoxicity against human MONO-MAC 6 cells assessed as [3H]thymidine incorporation after 48 hrs
[PMID: 9917317]
MONO-MAC-6 IC50
0.61 μM
Compound: 8; 55, 63
Cytotoxicity against human MONO-MAC-6 cells incubated for 48 hrs by [3H]-thymidine incorporation based liquid scintillation counter analysis
Cytotoxicity against human MONO-MAC-6 cells incubated for 48 hrs by [3H]-thymidine incorporation based liquid scintillation counter analysis
[PMID: 36496202]
SW-620 IC50
2 μM
Compound: HMD; 1a
Cytotoxicity against human SW620 cells by MTT assay
Cytotoxicity against human SW620 cells by MTT assay
[PMID: 33901899]
THP-1 IC50
1.36 μM
Compound: 1 (Hymenialdisine)
Inhibition of TNF-alpha production was determined in THP-1cells after LPS activation by Enzyme immunoassay
Inhibition of TNF-alpha production was determined in THP-1cells after LPS activation by Enzyme immunoassay
[PMID: 15214798]
THP-1 IC50
1.4 μM
Compound: 8; 55, 63
Antiinflammatory activity in LPS induced human THP-1 cells assessed as inhibition of TNF-alpha production by EIA assay
Antiinflammatory activity in LPS induced human THP-1 cells assessed as inhibition of TNF-alpha production by EIA assay
[PMID: 36496202]
In Vitro

10Z-Hymenialdisine displays a moderate effect on (ARK5, VEGFR-2, SAK and PDGFR) protein kinases. 10Z-Hymenialdisine shows a potent inhibition of RAF/MEK-1/MAPK cascade with an IC50 value of 6 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

324.13

Formula

C11H10BrN5O2

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1C2=C(C=C(N2)Br)/C(CCN1)=C3C(N=C(N/3)N)=O

Structure Classification
Initial Source

marine sponge Axinella carteri

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 3.24 mg/mL (10.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0852 mL 15.4259 mL 30.8518 mL
5 mM 0.6170 mL 3.0852 mL 6.1704 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0852 mL 15.4259 mL 30.8518 mL 77.1295 mL
5 mM 0.6170 mL 3.0852 mL 6.1704 mL 15.4259 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
10Z-Hymenialdisine
Cat. No.:
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