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  4. (16R)-Epothilone D

(16R)-Epothilone D  (Synonyms: (16R)-KOS 862)

Cat. No.: HY-15278A Purity: 95.11%
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(16R)-Epothilone D is the isomer of Epothilone D (HY-15278), and can be used as an experimental control. Epothilone D (KOS 862) is a potent microtubule stabilizer.

For research use only. We do not sell to patients.

(16R)-Epothilone D Chemical Structure

(16R)-Epothilone D Chemical Structure

Size Price Stock Quantity
2 mg USD 65 In-stock
5 mg USD 125 In-stock
10 mg USD 200 In-stock
25 mg USD 400 In-stock
50 mg USD 600 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (16R)-Epothilone D:

(16R)-Epothilone D Related Antibodies

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Description

(16R)-Epothilone D is the isomer of Epothilone D (HY-15278), and can be used as an experimental control. Epothilone D (KOS 862) is a potent microtubule stabilizer.

Molecular Weight

491.68

Formula

C27H41NO5S
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C[C@H](O)C1(C)C)O[C@@H](/C(C)=C/C2=CSC(C)=N2)C/C=C(C)\CCC[C@H](C)[C@H](O)[C@@H](C)C1=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Methanol : 69.25 mg/mL (140.84 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0338 mL 10.1692 mL 20.3384 mL
5 mM 0.4068 mL 2.0338 mL 4.0677 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 2.0338 mL 10.1692 mL 20.3384 mL 50.8461 mL
5 mM 0.4068 mL 2.0338 mL 4.0677 mL 10.1692 mL
10 mM 0.2034 mL 1.0169 mL 2.0338 mL 5.0846 mL
15 mM 0.1356 mL 0.6779 mL 1.3559 mL 3.3897 mL
20 mM 0.1017 mL 0.5085 mL 1.0169 mL 2.5423 mL
25 mM 0.0814 mL 0.4068 mL 0.8135 mL 2.0338 mL
30 mM 0.0678 mL 0.3390 mL 0.6779 mL 1.6949 mL
40 mM 0.0508 mL 0.2542 mL 0.5085 mL 1.2712 mL
50 mM 0.0407 mL 0.2034 mL 0.4068 mL 1.0169 mL
60 mM 0.0339 mL 0.1695 mL 0.3390 mL 0.8474 mL
80 mM 0.0254 mL 0.1271 mL 0.2542 mL 0.6356 mL
100 mM 0.0203 mL 0.1017 mL 0.2034 mL 0.5085 mL
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(16R)-Epothilone D Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(16R)-Epothilone D(16R)-KOS 862OthersInhibitorinhibitorinhibit

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